Iterative Guided Machine Learning-Assisted Systematic Literature Reviews: A Diabetes Case Study

Abstract

Background: Systematic Reviews (SR), studies of studies, use a formal process to evaluate the quality of scientific literature and determine ensuing effectiveness from qualifying articles to establish consensus findings around a hypothesis. Their value is increasing as the conduct and publication of research and evaluation has expanded and the process of identifying key insights becomes more time consuming. Text analytics and Machine Learning (ML) techniques may help overcome this problem of scale while still maintaining the level of rigor expected of SRs.Methods: In this article, we discuss an approach that uses existing examples of SRs to build and test a method for assisting the SR title and abstract pre-screening by reducing the initial pool of potential articles down to articles that meet inclusion criteria. Our approach differs from previous approaches to using ML as a SR tool in that it incorporates ML configurations guided by previously conducted SRs, and human confirmation on ML predictions of relevant articles during multiple iterative reviews on smaller tranches of citations. We applied the tailored method to a new SR review effort to validate performance.Results: The case study test of the approach proved a sensitivity (recall) in finding relevant articles during down selection that may rival many traditional processes.Conclusions: We believe this iterative method can help overcome bias in initial ML model training by having humans reinforce ML models with new and relevant information, and is an applied step towards transfer learning for ML in SR.

Natural Language Processing: from Bedside to Everywhere

“…Because this article is not a systematic review, we focused on studies that can directly contribute to daily clinical practice. Although NLP is also helpful in research-oriented applications, such as cohort building with patient identification or phenotyping [16], evidence generation using clinical free-text [17][18][19], or semi-automation of meta-analysis [20] and systematic review [21][22][23], these are beyond the scope of this article.…”