Itchy Papules of the Axillae

Ghislain, P.-D.

doi:10.1001/archderm.138.2.259-c

Cited by 7 publications

(1 citation statement)

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“…1,[3][4][5][9][10][11][12][13][14][15][16] There is general agreement that dilation of the follicular infundibulum with hyperkeratosis and keratin plugging is a common feature of FFD. 1,4,5,[9][10][11][12][13]15,16 Keratin plugging may be caused by keratinocyte dysmaturation, manifested by dyskeratosis and parakeratosis-the latter often resembling a cornoid lamella. 1,5,10,15 Blockage of the apocrine duct at the point of entry to the epidermis obstructs apocrine secretion 4 and causes apocrine duct and gland dilation.…”

Section: Commentmentioning

confidence: 99%

Fox-Fordyce Disease Following Axillary Laser Hair Removal

Tetzlaff¹,

Evans²,

DeHoratius³

et al. 2011

Arch Dermatol

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Background: Fox-Fordyce disease (FFD) is a relatively rare entity with a typical clinical presentation. Numerous studies have described unifying histopathological features of FFD, which together suggest a defect in the follicular infundibulum resulting in follicular dilation with keratin plugging, subsequent apocrine duct obstruction, and apocrine gland dilation, with eventual extravasation of the apocrine secretions as the primary histopathogenic events in the evolution of the disease. Observations: We describe a case of FFD that developed in a 41-year-old woman 3 months after completing a series of axillary laser hair removal treatments, and we detail the clinical and histopathological changes typical for FFD. Conclusion: Because defective infundibular maturation has been suggested to play a central role in the evolution of FFD, the close temporal relationship of laser hair therapy with the development of FFD suggests a causal role, which we continue to explore.

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Section: Commentmentioning

confidence: 99%

Fox-Fordyce Disease Following Axillary Laser Hair Removal

Tetzlaff¹,

Evans²,

DeHoratius³

et al. 2011

Arch Dermatol

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Fox–Fordyce-like disease following laser hair removal appearing on all treated areas

Hélou

Maatouk

Moutran³

et al. 2013

Lasers Med Sci

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Fox-Fordyce disease is an uncommon inflammatory disease of the apocrine sweat glands. Two recent reports indicated laser hair removal as a novel cause of axillary Fox-Fordyce disease. We report the first case of Fox-Fordyce disease developing in women after completing treatment with a depilatory hair laser appearing in the axillae, umbilicus, and pubis. We describe a case of Fox-Fordyce disease that developed in a 27-year-old woman 3 months after she had completed two LightSheer Diode laser treatments of her axilla, periumbilical region, and bikini area. Clinical and histopathological changes are as well detailed. Laser therapy induces damage to follicular infundibulum, resulting in altered maturation of keratinocytes which led to keratin plugging causing the common pathologic features in Fox-Fordyce disease. Differences in the physiologic features of the anatomic sites, in the susceptibility to laser-induced injury among these areas, or additional factors may contribute to Fox-Fordyce disease.

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The Skin and Pregnancy

Rapini¹

2009

Creasy and Resnik's Maternal-Fetal Medicine: Principles and Practice

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Itchy Papules of the Axillae

Cited by 7 publications

References 0 publications

Fox-Fordyce Disease Following Axillary Laser Hair Removal

Fox-Fordyce Disease Following Axillary Laser Hair Removal

Fox–Fordyce-like disease following laser hair removal appearing on all treated areas

The Skin and Pregnancy

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