Itch and IgE in atopic dermatitis

Rajka, G

doi:10.2340/00015555923839

Cited by 11 publications

(3 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 1961 Raika [6] confirmed these findings, showing that very often both skin prick tests (SPTs) and intradermal tests were positive to a panel of aero allergens, also in AD patients without clinical symptoms of respiratory allergy. Subsequently, it was demonstrated that specific IgE (and IgG) levels against the Der p 1 allergen were elevated in several test subjects affected with AD, and not with asthma.…”

Section: Advances In Biotechnology and Microbiologymentioning

confidence: 84%

Respiratory Manifestations of Food Allergy in Babies with Atopic Dermatitis: A Prospective Study in 395 Children

Cantani¹

2016

AIBM

View full text Add to dashboard Cite

Background Scientific evidence accumulated in recent years indicates that food and inhalant allergens can trigger atopic dermatitis (AD). It may be hypothesized that, also in AD, the allergens could induce a cutaneous hyper reactivity analogous to the bronchial hyper reactivity (BHR) described in allergic patients with asthma. Nonspecific stimuli can therefore trigger and worsen the skin lesions. Eosinophils, as in asthma, seem to play an important role in inducing and maintaining the skin lesions.Objective: Taken together, these data suggest that in AD there exists a vicious circle, by which immunologic and non immunologic factors act in various ways and at different levels triggering different, though synergistic, reactions to initiate, amplify and maintain the chronic skin lesions characteristic of the condition. Patients and methods:We have prospectively 395 atopic children attending our Division because they were affected with AD, and found 213/395 babies affected contemporaneously with AD and respiratory allergy. The diagnosis of atopic diseases in the children was done according to family and clinical history, physical examination and positive SPTs and/or RAST to the most common inhalant and/or food allergens Results. Of them 14 babies experienced a positive OFC (open challenge test) to different foods (9 cow milk CM , 5 hydrolysate formulas, HFs and one fish, but we stress that three of them reacted to one drop or two ml of CM) Positivity of family history and elevated total IgE confirm that AD is a genetic disease. Conclusion:The data confirms the studies that have suggested that allergens in turn could elicit respiratory symptoms that can be distinguished as food induced asthma and asthma with food allergy (FA). In summary, FA provokes wheezing in a small, but significant number of children suffering from AD and asthma, thus confronting pediatricians with one of the most demanding challenges

show abstract

Section: Advances In Biotechnology and Microbiologymentioning

confidence: 84%

Respiratory Manifestations of Food Allergy in Babies with Atopic Dermatitis: A Prospective Study in 395 Children

Cantani¹

2016

AIBM

View full text Add to dashboard Cite

show abstract

“…Sensory neurons expressing Mrgprs also regulate histamine-independent pruritus ( Wilson et al, 2011 ). Due to the critical role of various proteases, TRPs, and Mrgprs in skin homeostasis and the pathophysiology of pruritus ( Rajka, 1967 ; Steinhoff et al, 2003 ; Reddy et al, 2015 ; Coavoy-Sánchez et al, 2016 ), the co-participation of these receptors in the anti-pruriceptive effects of SGE was assessed. CQ is commonly used to prevent or treat malaria, but, as a side effect, produces intense itching in humans ( Sowunmi et al, 1989 ; Sowunmi et al, 2001 ) or in mice when i.d.…”

Section: Discussion and Concluding Remarksmentioning

confidence: 99%

Aedes aegypti salivary gland extract alleviates acute itching by blocking TRPA1 channels

et al. 2023

View full text Add to dashboard Cite

Aedes aegypti (Ae. aegypti) saliva induces a variety of anti-inflammatory and immunomodulatory activities. Interestingly, although it is known that mosquito bites cause allergic reactions in sensitised hosts, the primary exposure of humans to Ae. aegypti does not evoke significant itching. Whether active components in the saliva of Ae. aegypti can counteract the normal itch reaction to injury produced by a histaminergic or non-histaminergic pathway in vertebrate hosts is unknown. This study investigated the effects of Ae. aegypti mosquito salivary gland extract (SGE) on sensitive reactions such as itching and associated skin inflammation. Acute pruritus and plasma extravasation were induced in mice by the intradermal injection of either compound 48/80 (C48/80), the Mas-related G protein-coupled receptor (Mrgpr) agonist chloroquine (CQ), or the transient receptor potential ankyrin 1 (TRPA1) agonist allyl isothiocyanate (AITC). The i.d. co-injection of Ae. aegypti SGE inhibited itching, plasma extravasation, and neutrophil influx evoked by C48/80, but it did not significantly affect mast cell degranulation in situ or in vitro. Additionally, SGE partially reduced CQ- and AITC-induced pruritus in vivo, suggesting that SGE affects pruriceptive nerve firing independently of the histaminergic pathway. Activation of TRPA1 significantly increased intracellular Ca2+ in TRPA-1-transfected HEK293t lineage, which was attenuated by SGE addition. We showed for the first time that Ae. aegypti SGE exerts anti-pruriceptive effects, which are partially regulated by the histamine-independent itch TRPA1 pathway. Thus, SGE may possess bioactive molecules with therapeutic potential for treating nonhistaminergic itch.

show abstract

“…The view that the disease is a manifestation of atopy seems unlikely when a positive family history was obtained in only 28 per cent with second degree relatives being considered also, and about 30 per cent of normal persons have a family history of atopy in close relatives', whilst in patients presenting with atopic dermatitis a family history of atopy is obtained in 65 per cent of cases 10 . At present infantile seborrhoeic dermatitis remains a self‐limiting cutaneous disorder of obscure aetiology.…”

Section: Discussionmentioning

confidence: 99%

Candida albicans and infantile seborrhoeic dermatitis

Ilchyshyn¹,

MacFarlane³

et al. 1987

Int J Clinical Practice

View full text Add to dashboard Cite

Fifty infants with classical infantile seborrhoeic dermatitis were studied and Candida albicans was isolated from the skin in only nine (18 per cent) patients, although this is a greater incidence than in normal infants. Whether this organism plays a role in the aetiology of the condition, or is merely sometimes present on the skin as a secondary invader, rema ins unclear but the latter seems most likely. Infantile, seborrhoeic dermatitis is not a manifestation of atopy.

show abstract

Itch and IgE in atopic dermatitis

Abstract: It was found that a correlation exists between the values of IgE in the serum and the duration of experimental itch elicited by trypsin in 20 patients with atopic dermatitis.

Cited by 11 publications

References 1 publication

Respiratory Manifestations of Food Allergy in Babies with Atopic Dermatitis: A Prospective Study in 395 Children

Respiratory Manifestations of Food Allergy in Babies with Atopic Dermatitis: A Prospective Study in 395 Children

Aedes aegypti salivary gland extract alleviates acute itching by blocking TRPA1 channels

Candida albicans and infantile seborrhoeic dermatitis

Contact Info

Product

Resources

About