Itch: A Global Problem?

Weißhaar, Elke

doi:10.3389/fmed.2021.665575

Cited by 9 publications

(10 citation statements)

References 37 publications

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“…Itch in the general population is a widespread phenomenon, but one with a poorly defined epidemiology (Weisshaar, 2021;Weisshaar & Dalgard, 2009;Weisshaar & Matterne, 2014). Our study was not epidemiological in its design, however some approximated prevalence estimates can be made for the purpose of comparison.…”

Section: Epidemiology Of Itchmentioning

confidence: 99%

The Experience of Itch in Autistic Adults: An Online Survey

Tackley,

Unwin,

Underwood

et al. 2024

Preprint

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The self-reported experience of itch for autistic people has not been studied. Anecdote, theory, and emerging research suggest that itch experience is different in autistic people, with negative consequences. To address this, an online survey was completed by participants who self-categorised as diagnosed autistic (n=158), suspected autistic (n=37) or not autistic (n=85). We asked about three categories of itch: spontaneous, provoked, and itch caused by a medical condition, with questions focussed on severity, timing and duration, and impact on daily activities such as sleep. Across all categories of itch there was a pattern of greater severity, duration, and impact in diagnosed autistic people compared to non-autistic people, with large effect-size differences for spontaneous and provoked categories. Those with suspected autism largely fell between groups. Regression models showed itch severity associated with self-reported autistic traits. As expected, we found more dermatitis-related itch sufferers in autistic respondents. However, medical itch did not drive differences in spontaneous and provoked itch. Findings therefore suggest that the self-reported itch experience of autistic people is quantifiably more severe, longer lasting and of greater daily relevance, and that these differences cannot be attributed to the higher prevalence of skin dermatitis found in autism. Future studies are required to understand how itch experience fits into the broader picture of sensory differences, to understand mechanisms, and to develop management strategies for what can be a highly morbid experience.

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Section: Epidemiology Of Itchmentioning

confidence: 99%

The Experience of Itch in Autistic Adults: An Online Survey

Tackley,

Unwin,

Underwood

et al. 2024

Preprint

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“…To alleviate itching, topical and systemic solutions have been developed and applied with varying degrees of effectiveness. Nevertheless, it remains imperative to develop more speci c and e cient treatment methods [5].…”

Section: Introductionmentioning

confidence: 99%

Lasmiditan Ameliorates Serotonergic Itch in Mice: Possible Involvement of 5-HT1F Receptors

Afrooghe,

Ahmadi,

Babaei

et al. 2024

Preprint

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Purpose Previously, some allergic conditions involving pruritus have been linked to migraine, raising the possibility that migraine and itching may be governed by similar underlying mechanisms. We aimed to investigate the efficacy of lasmiditan, a highly selective agonist of the 5-Hydroxytriptamin 1F receptor (5-HT1FR) and a recently approved medication for the treatment of migraine headaches, in ameliorating serotonergic itching. Methods Eight animals were randomly assigned to each of the study groups: (1) “Sham”: The sham group was given intradermal injections of normal saline (2) “Ctrl”: The control group was injected with intradermal doses of 5-HT, which was used to induce itching. (3) “Las 0.3”, “Las 1”, and “Las 3” groups: injected with 5-HT as well as intraperitoneal lasmiditan at different dose levels (0.3, 1, and 3 mg/kg, respectively). scratching behavior was recorded for 60 minutes, and the skin tissue of three mice was sampled at the end of the behavioral experiment to assess the levels of TLR-4, IL-31, 5-HT1FR, CGRP & TRPV4. Results In the present study, we found that Lasmiditan when administered at 1mg/kg effectively reduced serotonin-induced itching compared to the “Ctrl” group (P < 0.0001). Following the administration of Lasmiditan (1mg/kg), the expression levels of the 5-HT2A receptor significantly increased (P < 0.01). Further, the levels of TLR-4, IL-31, CGRP & TRPV4 were substantially reduced upon the administration of Lasmiditan (1mg/kg). Conclusions We found that Lasmiditan is effective in reducing serotonergic itch in mice through its interaction with the 5-HT1F receptor in the skin tissue of mice.

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“…This symptom is not limited to hospital settings only; it is also common in private dermatology practices. In another private practice based study in Germany, over a third (36.2 %) of the patients reported itching over a one-week period, where the majority (87.6 %) of these cases were chronic in nature [ 3 ]. Children typically have a higher prevalence of atopic dermatitis than adults do, according to data on the incidence and prevalence of the condition.…”

Section: Introductionmentioning

confidence: 99%

Ayurvedic herbal formulations Haridra Khanda and Manjisthadi Kwath (brihat) in the management of allergic rhinitis: A pharmacological study

Bhowmik,

Shaharyar,

Kanakal

et al. 2024

Heliyon

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Itch: A Global Problem?

Cited by 9 publications

References 37 publications

The Experience of Itch in Autistic Adults: An Online Survey

The Experience of Itch in Autistic Adults: An Online Survey

Lasmiditan Ameliorates Serotonergic Itch in Mice: Possible Involvement of 5-HT1F Receptors

Ayurvedic herbal formulations Haridra Khanda and Manjisthadi Kwath (brihat) in the management of allergic rhinitis: A pharmacological study

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