Italian patients with hemoglobinopathies exhibit a 5‐fold increase in age‐standardized lethality due to SARS‐CoV‐2 infection

Longo, Filomena; Gianesin, Barbara; Voi, Vincenzo; Motta, Irene; Valeria, María; Piolatto, Andrea; Spasiano, Anna; Ruffo, Giovan Battista; Gamberini, Maria Rita; Barella, Susanna; Mariani, Raffaella; Fidone, Carmelo; Rosso, Rosamaria; Casale, Maddalena; Roberti, Domenico; Zotto, Chiara Dal; Vitucci, Angelantonio; Bonetti, F; Pitrolo, Lorella; Quaresima, Micol; Ribersani, Michela; Quota, Alessandra; Arcioni, Francesco; Campisi, Saveria; Massa, Antonella; Michele, Elisa De; Lisi, Roberto; Miano, Maurizio; Bagnato, Sabrina; Gentile, Massimo; Carrai, Valentina; Putti, Maria Caterina; Serra, Maurizio; Gaglioti, Carmen; Amicis, Margerita Migone De; Graziadei, Giovanna; Giovanni, Anna De; Ricchi, Paolo; Balocco, Manuela; Quintino, Sabrina; Borsellino, Zelia; Fortini, Monica; Denotti, Anna Rita; Tartaglione, Immacolata; Beccaria, A; Marziali, Marco; Maggio, Aurelio; Perrotta, Silverio; Piperno, Alberto; Filosa, Aldo; Cappellini, Maria Domenica; Franceschi, Lucia De; Piga, Antonio; Forni, Gian Luca

doi:10.1002/ajh.26429

Cited by 11 publications

(9 citation statements)

References 6 publications

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“…In any case, and whatever being the mechanism of action, the beneficial effect of Sirolimus treatment on COVID‐19 vaccination might be of great interest for managing β‐Thalassemia, as an increased mortality risk from COVID‐19 was observed in Italian patients affected by hemoglobinopathies, including β‐Thalassemia. 75 A further issue in β‐Thalassemia is premature ageing of the immune system, that has been suggested to affect the response to SARS‐CoV‐2 mRNA vaccine. 76 Considering that autophagy and mitophagy in T cells decrease with age, 10 the induction/potentiation of these biological processes in elderly should be considered of great importance.…”

Section: Discussionmentioning

confidence: 99%

Effects of Sirolimus treatment on patients with β‐Thalassemia: Lymphocyte immunophenotype and biological activity of memory CD4⁺ and CD8⁺ T cells

Zurlo

Nicoli

Proietto

et al. 2023

J Cellular Molecular Medi

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Section: Discussionmentioning

confidence: 99%

Effects of Sirolimus treatment on patients with β‐Thalassemia: Lymphocyte immunophenotype and biological activity of memory CD4⁺ and CD8⁺ T cells

Zurlo

Nicoli

Proietto

et al. 2023

J Cellular Molecular Medi

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“…5 Patients with B-thalassemia show a 5-fold increase in age-standardized lethality due to SARSCov2, representing a high-risk population compared with age and sex-matched healthy subjects. 6 A long-lived protective immunity after primary infection/immunization seems unlikely, and the immune response generated to earlier variants may not cover newer ones.…”

Section: To the Editormentioning

confidence: 99%

“…Patients with B-thalassemia show a 5-fold increase in age-standardized lethality due to SARSCov2, representing a high-risk population compared with age and sex-matched healthy subjects. 6 …”

mentioning

confidence: 99%

Epidemiological surveillance of SARSCov2 in β-Thalassemia Patients in the last two years: reinfection rate, insights and future challenges

Torti

Sorrentino

Maffei

et al. 2023

Mediterr J Hematol Infect Dis

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Background: Although the association between comorbidities and the severity of COVID-19 infection has been extensively discussed, data on COVID-19 and hemoglobinopathies are still limited. SARS-Cov2 reinfections with severe acute respiratory syndrome have been described in the general population, usually with a milder outcome compared to the primary infection. The aim of our study was to determine the rate of reinfection and clinical features in a population of β-thalassemia patients. Results: Following the first infection, patients showed an adequate humoral immune response, however, all four patients are considered immune impaired owing to chronic transfusional support coupled with iron chelating treatment and splenectomy in three of the four.

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“…Beta thalassemia major was found to be most frequent (29.4%), followed by sickle/beta thalassemia heterozygous disease (28.3%) and sickle cell anemia (28%) [4]. Thalassemia, being a chronic disease, is associated with many co-morbidities and complications including diabetes, pulmonary hypertension and heart failure leading to increased risk of severe COVID-19 and 5 fold increase in lethality due to COVID-19 infection [5].…”

Section: Introductionmentioning

confidence: 99%

Implementation, Patient Satisfaction and Usability of Telemedicine Services for Pediatric Thalassemia Cases in Balochistan During COVID-19 Pandemic and Beyond

Akram¹,

Khan²

2022

AJP

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Background: Telemedicine health service has revolutionized delivery of health care to the doorsteps of needy and deserving cases especially since the onset of the recent pandemic; COVID-19. Beta thalassemia major children require lifelong medical care, despite any untoward circumstances. Aim of this study is to identify role of telemedicine in diagnosing, treating and following-up of thalassemia cases and assess patient satisfaction. Objective: To assess implementation, patient satisfaction and usability of telemedicine health service for pediatric thalassemia cases in Northern Balochistan. Study place and duration: Study was carried out at District Headquarter Hospital Zhob from April 2021 to September 2021. Material & methods: Telemedicine service was established at Pediatric Department DHQ Hospital Zhob during COVID-19 pandemic. The data of all thalassemia cases that were managed/provided health care via telemedicine was collected and recorded. Patient satisfaction and usability of telemedicine service provided was assessed using a questionnaire prepared after thorough study of literature. The parents and care-givers of thalassemia cases treated via telemedicine were interviewed on mobile cell phones/telephone and the questionnaires were filled. Overall satisfaction was also gauged according to a scale from 1 to 5, where 1 depicted extremely dissatisfaction and 5 showed extreme satisfaction. The data was analyzed with Statistical package for social science (SPSS 21). Results: Total 347 patients of thalassemia received telemedicine health service during the study period. There were 182 (52.4%) males and 165 (47.6%) females with age range of 1 -15 years (mean age 8.09 + 3.47 years). Total 289 (83.3%) telemedicine service seekers were residing in rural areas and rest 58 (16.7%) resided in urban areas. Ninety seven families (28%) belonged to poor class, 192 (55.35) belonged to lower middle class, 55 (15.9%) belonged to upper middle class and 3 (0.9%) belonged to rich class. Majority of participants (97.4%) were significantly satisfied with telemedicine service (p value 0.001). Conclusion: During current COVID-19 pandemic telemedicine has emerged as an exceptional alternate mode of healthcare delivery. It saves cost and time of travelling for thalassemia cases who require life-long hospital visits and follow-up. People have shown high satisfaction and positive attitude towards telemedicine health service provision.

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Italian patients with hemoglobinopathies exhibit a 5‐fold increase in age‐standardized lethality due to SARS‐CoV‐2 infection

Cited by 11 publications

References 6 publications

Effects of Sirolimus treatment on patients with β‐Thalassemia: Lymphocyte immunophenotype and biological activity of memory CD4⁺ and CD8⁺ T cells

Effects of Sirolimus treatment on patients with β‐Thalassemia: Lymphocyte immunophenotype and biological activity of memory CD4⁺ and CD8⁺ T cells

Epidemiological surveillance of SARSCov2 in β-Thalassemia Patients in the last two years: reinfection rate, insights and future challenges

Implementation, Patient Satisfaction and Usability of Telemedicine Services for Pediatric Thalassemia Cases in Balochistan During COVID-19 Pandemic and Beyond

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Italian patients with hemoglobinopathies exhibit a 5‐fold increase in age‐standardized lethality due to SARS‐CoV‐2 infection

Cited by 11 publications

References 6 publications

Effects of Sirolimus treatment on patients with β‐Thalassemia: Lymphocyte immunophenotype and biological activity of memory CD4+ and CD8+ T cells

Effects of Sirolimus treatment on patients with β‐Thalassemia: Lymphocyte immunophenotype and biological activity of memory CD4+ and CD8+ T cells

Epidemiological surveillance of SARSCov2 in β-Thalassemia Patients in the last two years: reinfection rate, insights and future challenges

Implementation, Patient Satisfaction and Usability of Telemedicine Services for Pediatric Thalassemia Cases in Balochistan During COVID-19 Pandemic and Beyond

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Effects of Sirolimus treatment on patients with β‐Thalassemia: Lymphocyte immunophenotype and biological activity of memory CD4⁺ and CD8⁺ T cells

Effects of Sirolimus treatment on patients with β‐Thalassemia: Lymphocyte immunophenotype and biological activity of memory CD4⁺ and CD8⁺ T cells