Italian consensus for the classification and reporting of thyroid cytology

Nardi, Francesco; Basolo, Fulvio; Crescenzi, Anna; Fadda, Guido; Frasoldati, Andrea; Orlandi, Fabio; Palombini, Lucio; Papini, Enrico; Zini, Michele; Pontecorvi, Alfredo; Vitti, Paolo

doi:10.1007/s40618-014-0062-0

Cited by 330 publications

(343 citation statements)

References 44 publications

Supporting

Mentioning

333

Contrasting

Order By: Relevance

“…Nodules at high risk and those at low‐to‐intermediate risk larger than 20 mm underwent cytological analysis of specimens gained by FNAC. Cytopathology results were reported according to the Società Italiana di Anatomia Patologica e Citopatologia/International Association of Pathology (SIAPEC/IAP) classification system (ie, TIR 1, nondiagnostic; TIR 2, benign; TIR 3, follicular lesion; TIR 4, suspicious for malignancy; TIR 5, malignant) 29, 30. Patients with TIR 3, 4 and 5 cytological outcomes underwent surgery.…”

Section: Methodsmentioning

confidence: 99%

Procalcitonin measurement to screen medullary thyroid carcinoma: A prospective evaluation in a series of 2705 patients with thyroid nodules

Giovanella

Imperiali

Piccardo

et al. 2018

Eur J Clin Investigation

View full text Add to dashboard Cite

BackgroundTo prospectively evaluate the role of procalcitonin (PCT) in screening of patients with thyroid nodules for medullary thyroid carcinoma (MTC).Materials and methodsWe measured PCT in 2705 patients with thyroid nodules referred to our centre between January 2011 and December 2017. Those with a positive PCT were operated after positive confirmatory tests such as fine‐needle aspiration, measurement of calcitonin (CT) in serum and fine‐needle aspiration washouts or CT stimulation testing. Patients with a negative PCT were operated based on the results of further diagnostics. The diagnostic performance of PCT was evaluated, and the best cut‐off level was selected by ROC curve analysis.ResultsAmong 2705 patients, 9 with positive serum PCT (ie, above 0.1 μg/L) and 370 with negative PCT underwent thyroid surgery. MTC was histologically confirmed in all patients with positive PCT but not found in patients with negative PCT. Serum PCT levels were significantly higher in patients with MTC (median 0.64 μg/L, range 0.16‐12.9 μg/L) than in those without (median 0.075 μg/L, range 0.075‐0.16 μg/L; P < .0001). ROC curves were plotted to calculate the optimal PCT value separating patients with MTC from those without. The best cut‐off was 0.155 μg/L with sensitivity, specificity, positive and negative predictive values as well as accuracy of 100%, 99.7%, 91.7%, 100% and 99.7%, respectively. Positive and negative likelihood ratios were 329 and zero, respectively.ConclusionsMeasurement of PCT is a sensitive and accurate method for detecting MTC in patients with thyroid nodules and can thus be a reliable alternative to CT measurement.

show abstract

Section: Methodsmentioning

confidence: 99%

Procalcitonin measurement to screen medullary thyroid carcinoma: A prospective evaluation in a series of 2705 patients with thyroid nodules

Giovanella

Imperiali

Piccardo

et al. 2018

Eur J Clin Investigation

View full text Add to dashboard Cite

show abstract

“…The material was airdried, stained with Papanicolaou and Giemsa. Cytological results were classified according to the criteria of the Italian Consensus for the classification and reporting of thyroid cytology (37).…”

Section: Fna and Cytological Diagnosismentioning

confidence: 99%

‘Incidental’ and ‘non-incidental’ thyroid papillary microcarcinomas are two different entities

Provenzale

Fiore

Ugolini

et al. 2016

European Journal of Endocrinology

Self Cite

View full text Add to dashboard Cite

Objective Papillary thyroid microcarcinomas (microPTC) may be ’incidental’ (Inc-microPTC), occasionally found at histology after surgery for benign disease or ‘non-incidental’ (Non-Inc-microPTC), diagnosed on clinical grounds. It is unclear whether these different microPTC reflect the same disease. The aim of the study was to compare Inc-microPTC and Non-Inc-microPTC for clinical and histological features as well as for serum TSH, a known factor involved in PTC development. Design We evaluated histology and serum TSH levels of consecutive patients submitted to thyroidectomy for goiter with compressive symptoms or for cytological diagnosis suspicious/indicative of PTC. Methods In total, 665 consecutive patients (259 with a single thyroid nodule, SN and 406 with a multinodular gland, MN) were included in the study. According to histology, patients were classified as: benign nodular goiter (Benign, n=291); Inc-microPTC (n=92); Non-Inc-microPTC (n=67) and PTC≥1cm (macroPTC, n=215). Results Inc-microPTC were significantly more frequent in MN than in SN (66/406, 16.2% vs 26/259, 10.0%, P=0.02). Patients with Inc-microPTC compared with Non-Inc-microPTC were older (mean age±s.d. 53.3±13.2 years vs 44.9±14.8 years, P=0.0002), had a smaller tumor size (median 4mm vs 9mm, P<0.0001), a higher frequency of multifocality (70/92, 76.1% vs 35/67, 52.2% P=0.001) and lower levels of TSH (median 0.6mIU/L, IR: 0.4–1.0mIU/L vs value 1. mIU/L, IR: 0.6–1.4mIU/L vs P=0.0001). Conclusion Incidental and non-incidental papillary thyroid microcarcinomas appear to be two different entities.

show abstract

“…In 2012, the Italian Societies of Endocrinology and the SIAPEC-IAP [12] appointed a working panel of experts to update the former consensus. They present a cytological classification that differs from the previous one in having introduced, in addition to the "Tir 1" category (inadequate sampling, to be repeated), the "Tir 1C" category (cystic nodules; non-diagnostic, but not to be repeated) ( Table 1).…”

Section: Second-tier Assessmentsmentioning

confidence: 99%

“…This further subdivision of "Tir3" aims at reducing the percentage of nodules with indeterminate cytology to be submitted to surgery [12]. Immunocytochemical and/ or molecular genetic markers can be used to complement cytology: calcitonin, chromogranin A and CEA are used in suspected medullary carcinoma, whereas PTH can detect parathyroid lesions [1,12].…”

Section: Second-tier Assessmentsmentioning

confidence: 99%

See 1 more Smart Citation

Diagnostic, therapeutic and health-care management protocol in thyroid surgery: a position statement of the Italian Association of Endocrine Surgery Units (U.E.C. CLUB)

Rosato

Crea

Bellantone

et al. 2016

J Endocrinol Invest

View full text Add to dashboard Cite

members, via e-mail, in the elaboration phase; all the participants of the XI National Congress of the U.E.C. CLUB held in Naples in the final phase. The following were examined: diagnostic pathway and clinical evaluation; mode of admission and waiting time; therapeutic pathway (patient preparation for surgery, surgical treatment, postoperative management, management of major complications); hospital discharge and patient information; outpatient care and follow-up. Results A clear and concise style was adopted to illustrate the reasons and scientific rationales behind behaviors and to provide health-care professionals with a guide as complete AbstractPurpose The diagnostic, therapeutic and health-care management protocol (Protocollo Gestionale DiagnosticoTerapeutico-Assistenziale, PDTA) by the Association of the Italian Endocrine Surgery Units (U.E.C. CLUB) aims to help treat the patient in a topical, rational way that can be shared by health-care professionals. Methods This fourth consensus conference involved: a selected group of experts in the preliminary phase; all Electronic supplementary material The online version of this article

show abstract

Italian consensus for the classification and reporting of thyroid cytology

Cited by 330 publications

References 44 publications

Procalcitonin measurement to screen medullary thyroid carcinoma: A prospective evaluation in a series of 2705 patients with thyroid nodules

Procalcitonin measurement to screen medullary thyroid carcinoma: A prospective evaluation in a series of 2705 patients with thyroid nodules

‘Incidental’ and ‘non-incidental’ thyroid papillary microcarcinomas are two different entities

Diagnostic, therapeutic and health-care management protocol in thyroid surgery: a position statement of the Italian Association of Endocrine Surgery Units (U.E.C. CLUB)

Contact Info

Product

Resources

About