It takes two to remyelinate: A bioengineered platform to study astrocyte-oligodendrocyte crosstalk and potential therapeutic targets in remyelination

Rocha, Daniela N.; Carvalho, Eva Daniela; Pires, Liliana R.; Gardin, Chiara; Zanolla, Ilaria; Szewczyk, Piotr K.; Machado, C. R.; Fernandes, Rui; Stachewicz, Urszula; Zavan, Barbara; Relvas, João B.; Pêgo, Ana Paula

doi:10.1016/j.bioadv.2023.213429

Biomaterials Advances

2023

DOI: 10.1016/j.bioadv.2023.213429

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It takes two to remyelinate: A bioengineered platform to study astrocyte-oligodendrocyte crosstalk and potential therapeutic targets in remyelination

Daniela N. Rocha

Eva Daniela Carvalho

Liliana R. Pires

et al.

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Oil‐Infused Polymer Fiber Membranes as Porous Patches for Long‐Term Skin Hydration and Moisturization

Szewczyk,

Kopacz,

Krysiak

et al. 2023

Macro Materials & Eng

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Skin allergies and diseases, including atopic dermatitis (AD), affect millions worldwide. Current treatments for AD are often expensive, leading to a need for cost‐effective solutions. Here, using fiber‐based patches to maintain and increase skin hydration is explored, which helps treat eczema and AD. Nanofiber membranes are manufactured via electrospinning of eight different polymers: nylon 6 (PA6), polyimide (PI), poly(3‐hydroxybuty‐rate‐co‐3‐hydroxyvalerate (PHBV), poly(l‐lactide) (PLLA), polycaprolactone (PCL), and polystyrene (PS), and two molecular weights poly(vinyl butyral‐co‐vinyl alcohol‐co‐vinyl acetate) (PVB). Further, their morphology is examined through scanning electron microscopy (SEM), fibers, and pores diameter, wettability, and membrane thickness. Additionally, water vapor transmission rates (WVTR) are measured, and notably, skin hydration tests are conducted before and after using evening primrose oil‐infused patches. The comparison and findings highlight the flexibility of electrospun patches, demonstrating their potential in maintaining skin hydration for 6 h and enhancing skin moisture, which are necessary in AD treatment. These insights, which focus on selecting the most effective performance patches, help improve skin moisture, leading to tailored treatments for AD, which can significantly impact the efforts to reduce healthcare costs and simplify skincare steps.

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Oil‐Infused Polymer Fiber Membranes as Porous Patches for Long‐Term Skin Hydration and Moisturization

Szewczyk,

Kopacz,

Krysiak

et al. 2023

Macro Materials & Eng

Self Cite

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It takes two to remyelinate: A bioengineered platform to study astrocyte-oligodendrocyte crosstalk and potential therapeutic targets in remyelination

Cited by 1 publication

References 101 publications

Oil‐Infused Polymer Fiber Membranes as Porous Patches for Long‐Term Skin Hydration and Moisturization

Oil‐Infused Polymer Fiber Membranes as Porous Patches for Long‐Term Skin Hydration and Moisturization

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