It Takes a Matured mAb to Treat Ebolavirus Infection

Patel, Ami; Weiner, David B.

doi:10.1016/j.chom.2018.12.013

Cited by 1 publication

(1 citation statement)

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“…mAb cocktails have successfully been used to prevent or treat infections with RNA viruses ( 38 ). For instance, although the individual Regeneron 10933 (casirivimab) and 10987 (imdevimab) mAbs against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are affected by a range of residue substitutions detected in clinical isolates, their combined cocktail proved more resilient to escape mutations ( 39 , 40 ).…”

Section: Resultsmentioning

confidence: 99%

Architecture and antigenicity of the Nipah virus attachment glycoprotein

Wang

Amaya

Addetia

et al. 2022

Science

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Nipah virus (NiV) and Hendra virus (HeV) are zoonotic henipaviruses (HNVs) responsible for outbreaks of encephalitis and respiratory illness. The entry of HNVs into host cells requires the attachment (G) and fusion (F) glycoproteins, which are the main targets of antibody responses. To understand viral infection and host immunity, we determined a cryo–electron microscopy structure of the NiV G homotetrameric ectodomain in complex with the nAH1.3 broadly neutralizing antibody Fab fragment. We show that a cocktail of two nonoverlapping G-specific antibodies neutralizes NiV and HeV synergistically and limits the emergence of escape mutants. Analysis of polyclonal serum antibody responses elicited by vaccination of macaques with NiV G indicates that the receptor binding head domain is immunodominant. These results pave the way for implementing multipronged therapeutic strategies against these deadly pathogens.

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Section: Resultsmentioning

confidence: 99%