It's Bordetella, It's Alcaligenes… No, It's Achromobacter! Identification, Antimicrobial Resistance, and Clinical Significance of an Understudied Gram-Negative Rod

Snavely, Emily; Precit, Mimi R.

doi:10.1016/j.clinmicnews.2022.10.001

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…However, following the ESLL intervention, the abundance of Achromobacter was significantly reduced. It has been reported that Achromobacter is an opportunistic pathogen [ 39 ], and its proliferation can induce damage to the intestinal barrier [ 40 ], leading to the entry of LPS from the gut into the bloodstream, which can trigger systemic inflammation [ 41 ]. This is consistent with the results of this study, which showed significant positive correlations between serum LPS, TNF-α, IL-6, and IL-1β levels and the abundance of Achromobacter .…”

Section: Discussionmentioning

confidence: 99%

Elephantopus scaber L. Polysaccharides Alleviate Heat Stress-Induced Systemic Inflammation in Mice via Modulation of Characteristic Gut Microbiota and Metabolites

Wang,

Sun,

Deng

et al. 2024

Nutrients

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Elephantopus scaber L. (ESL) is a Chinese herb that is used both as a food and medicine, often being added to soups in summer in south China to relieve heat stress (HS), but its exact mechanism of action is unknown. In this study, heat-stressed mice were gavaged with ESL polysaccharides (ESLP) at 0, 150, 300, and 450 mg/kg/d−1 (n = 5) for seven days. The gut microbiota composition, short-chain fatty acids (SCFAs), seven neurotransmitters in faeces, expression of intestinal epithelial tight junction (TJ) proteins (Claudin-1, Occludin), and serum inflammatory cytokines were measured. The low dose of ESLP (ESLL) improved the adverse physiological conditions; significantly reduced the cytokines (TNF-α, IL-1β, IL-6) and lipopolysaccharide (LPS) levels (p < 0.05); upregulated the expression of Claudin-1; restored the gut microbiota composition including Achromobacter and Oscillospira, which were at similar levels to those in the normal control group; significantly increased beneficial SCFAs like butyric acid and 5-HT levels in the faeces of heat-stressed mice; and significantly decreased the valeric acid and glutamic acid level. The level of inflammatory markers significantly correlated with the above-mentioned indicators (p < 0.05). Thus, ESLL reduced the HS-induced systemic inflammation by optimizing gut microbiota (Achromobacter, Oscillospira) abundance, increasing gut beneficial SCFAs like butyric acid and 5-HT levels, and reducing gut valeric and glutamic acid levels.

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Section: Discussionmentioning

confidence: 99%

Elephantopus scaber L. Polysaccharides Alleviate Heat Stress-Induced Systemic Inflammation in Mice via Modulation of Characteristic Gut Microbiota and Metabolites

Wang,

Sun,

Deng

et al. 2024

Nutrients

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“…During diagnostic culturing and identification, various Achromobacter species are frequently identified as A. xylosoxidans due to technical limitations ( 20 ), and by some older methods such as morphological and biochemical phenotyping even as P. aeruginosa or Burkholderia cepacia complex ( 21 ). Whether or not it is clinically relevant to better discriminate between different Achromobacter species is not fully understood, as the virulence of both A. xylosoxidans and other Achromobacter species is poorly characterized ( 22 ).…”

Section: Introductionmentioning

confidence: 99%

Exoproducts of the Most Common Achromobacter Species in Cystic Fibrosis Evoke Similar Inflammatory Responses In Vitro

et al. 2023

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Impact of antibiotic therapy on cutaneous and gut microbiota in Rana dybowskii amphibians: Insights and implications

Long,

Dong,

et al. 2024

Aquaculture

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It's Bordetella, It's Alcaligenes… No, It's Achromobacter! Identification, Antimicrobial Resistance, and Clinical Significance of an Understudied Gram-Negative Rod

Cited by 3 publications

References 16 publications

Elephantopus scaber L. Polysaccharides Alleviate Heat Stress-Induced Systemic Inflammation in Mice via Modulation of Characteristic Gut Microbiota and Metabolites

Elephantopus scaber L. Polysaccharides Alleviate Heat Stress-Induced Systemic Inflammation in Mice via Modulation of Characteristic Gut Microbiota and Metabolites

Exoproducts of the Most Common Achromobacter Species in Cystic Fibrosis Evoke Similar Inflammatory Responses In Vitro

Impact of antibiotic therapy on cutaneous and gut microbiota in Rana dybowskii amphibians: Insights and implications

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