It is not just about molecules! Optimal cancer care for the future needs more research on external factors

Henriksson, Roger

doi:10.1080/0284186x.2020.1726458

Cited by 1 publication

(1 citation statement)

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“…Lower physical activity volume, poor metabolic parameters, increased stress and fatigue perception may cluster together, leading to a worsening of CAR. These mechanisms may play a complementary role [50] in determining the increased cardiometabolic risk observed in breast cancer survivors and might provide an explanation for the "risk factor gap" [15], supporting interventions aiming to improve the sympathetic-parasympathetic balance such as lifestyle management. ANSI might thus offer a simple metric to quantify CAR in a clinical setting, using a personalized medicine approach.…”

Section: Discussionmentioning

confidence: 99%

Evidence of Better Autonomic, Metabolic and Psychological Profile in Breast Cancer Survivors Meeting Current Physical Activity Recommendations: An Observational Study

Lucini

Malacarne

Gatzemeier

et al. 2022

JPM

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The increased cardiometabolic risk observed in breast cancer survivors (BCS) is due to multiple mechanisms: Hormonal and immunological dysfunction are well-identified ones, while cardiac autonomic regulation (CAR) is less recognized but may play a new complementary role particularly relevant when considering conditions and behaviors associated with a better prognosis in BCS, such as physical training. This observational study investigated a group of consecutive (172) BCS subdivided in two groups: those who reached the physical activity goals above 600 (MET·min/week) and those who did not. We assessed CAR by autoregressive spectral analysis of cardiovascular variabilities (considering in particular the unitary autonomic nervous system index—ANSI), body mass composition, stress perception and lifestyle in order to verify possible differences due to execution of physical activity. Subjects who spontaneously met physical activity recommendations presented a better autonomic, metabolic and psychological profile compared to those who did not. Lower physical activity volume, poor metabolic parameters, increased stress and fatigue perception may cluster together, leading to worsened CAR. This control mechanism may play a complementary role in determining the increased cardiometabolic risk observed in BCS. Furthermore, it may also explain, albeit in part, the better prognosis observed in patients following interventions aiming to improve the sympathetic–parasympathetic balance, such as physical training, using a personalized medicine approach.

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Section: Discussionmentioning

confidence: 99%