It is no skin off my nose

Ho, Jessica S.S.; Li, Carmen H.; Wang, Ami; Asai, Yuka

doi:10.1016/j.anai.2021.04.018

Cited by 4 publications

(4 citation statements)

References 56 publications

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“…There are several similarities and differences in the structure and function of epithelial barriers between the skin, the gastrointestinal system, and the respiratory tract 15 . A disruption in the epithelial barrier could be a common pathway in the development of multiple allergic conditions 365,366 . The interaction between the epithelium and immune cells in addition to crosstalk with microbiota and environmental factors enroll in the pathogenesis of atopic disorders, including AD, AR, asthma, CRS as well as eosinophilic esophagitis and FA 367,368 (Table 2).…”

Section: Epithelial Barrier Damage and The Link Between Allergic Dise...mentioning

confidence: 99%

“…15 A disruption in the epithelial barrier could be a common pathway in the development of multiple allergic conditions. 365,366 The interaction between the epithelium and immune cells in addition to crosstalk with microbiota and environmental factors enroll in the pathogenesis of atopic disorders, including AD, AR, asthma, CRS as well as eosinophilic esophagitis and FA 367,368 (Table 2). Dysbiosis in the gut microbiota has effects on the immunity of distal organs, such as the lungs, in addition to modulating the immune responses of the gastrointestinal tract itself.…”

Section: Epithelial Barrier Damag E and The Link B E T Ween Allerg I ...mentioning

confidence: 99%

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Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease

Sözener

Öztürk

Çerçi

et al. 2022

Allergy

183

166

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Environmental exposure plays a major role in the development of allergic diseases.The exposome can be classified into internal (e.g., aging, hormones, and metabolic processes), specific external (e.g., chemical pollutants or lifestyle factors), and general external (e.g., broader socioeconomic and psychological contexts) domains, all of which are interrelated. All the factors we are exposed to, from the moment of conception to death, are part of the external exposome. Several hundreds of thousands of new chemicals have been introduced in modern life without our having a full understanding of their toxic health effects and ways to mitigate these effects.Climate change, air pollution, microplastics, tobacco smoke, changes and loss of biodiversity, alterations in dietary habits, and the microbiome due to modernization, urbanization, and globalization constitute our surrounding environment and external exposome. Some of these factors disrupt the epithelial barriers of the skin and mucosal surfaces, and these disruptions have been linked in the last few decades to the increasing prevalence and severity of allergic and inflammatory diseases such as atopic dermatitis, food allergy, allergic rhinitis, chronic rhinosinusitis, eosinophilic

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Section: Epithelial Barrier Damage and The Link Between Allergic Dise...mentioning

confidence: 99%

Section: Epithelial Barrier Damag E and The Link B E T Ween Allerg I ...mentioning

confidence: 99%

Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease

Sözener

Öztürk

Çerçi

et al. 2022

Allergy

183

166

View full text Add to dashboard Cite

show abstract

“… 5 , 6 This is the same gene that underlies other atopic conditions such as atopic dermatitis (AD), asthma, allergic rhinitis and certain food allergies. 7 , 8 The increased permeability of the skin barrier allows allergic contact sensitization to occur causing allergic contact dermatitis (ACD) of the hands, as well as increased penetrance of irritants to create the basis of irritant contact dermatitis (ICD). Filaggrin mutations may increase susceptibility to hand eczema that is characterized by both ACD and ICD.…”

Section: Pathogenesis Of Hand Eczemamentioning

confidence: 99%

A Review of Existing and New Treatments for the Management of Hand Eczema

Molin

2023

J Cutan Med Surg

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Hand eczema is a chronic condition that affects an estimated 14.5% of the general population. It has severe quality of life ramifications in those that struggle with it, including days missed from work or school, productivity loss and impaired work functioning. For years, the standard of care included topical moisturizing creams, topical steroids and more recently systemic agents. As new therapeutic targets emerge and recent advances are being developed, it is now more possible than ever that hand eczema can be managed via the underlying mechanisms. A review of the literature was conducted to identify current treatment options for hand eczema and chronic hand eczema. The terms ‘hand eczema’, ‘hand dermatitis’ were used to search PubMed, CENTRAL and Embase. To identify new therapies still undergoing investigation, we used the terms ‘hand eczema’, ‘hand dermatitis’, ‘atopic dermatitis’, and ‘vesicular eczema of hands and/or feet’ to search Clinicaltrials.gov for all studies until December 2022. There were 56 ongoing clinical trials identified for pharmacological treatments for hand eczema on Clinicaltrials.gov from 2000 - 2022, with 16 that are new or ongoing. These included studies for dupilumab, ruxolitinib, delgocitinib (LEO124249), gusacitinib (ASN002), AFX 5931, and roflumilast (ARQ-252). Two major classes of drugs emerging for the treatment of hand eczema include IL-4/IL-13 inhibitors and JAK inhibitors. With the increase in efficacy seen with these new drugs, we are also noting improved adverse effect profiles, making them attractive options to add to a clinician’s management toolbox for patients with hand eczema.

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“…Therefore, LAR is considered to result from compromised local nasal mucosal barriers allowing allergens to enter. The nasal mucosal barrier is the first line of defense against external pathogens [9]. A dysfunctional epithelial barrier may lead to enhanced uptake of allergens and exogenous particles, leading to increased activation of mast cells and nerve fibers [6,10,11].…”

Section: Introductionmentioning

confidence: 99%

Yingxiang Acupoint Embedding Improves Mucosal Barrier Function in Rats with Local Allergic Rhinitis

Xiang,

Zhang,

Jing

et al. 2024

Int Arch Allergy Immunol

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Introduction: Epithelial barrier disruption is the initial cause of various diseases. We previously reported that acupoint catgut embedding (AE) improves tight junction proteins (TJs) in rats with allergic rhinitis. However, whether AE improves the epithelial barrier in local allergic rhinitis (LAR) remains unknown. Methods: A total of 36 Sprague Dawley (SD) male rats aged 5–7 weeks were divided into 6 groups with 6 rats each: control group, LAR model group, false acupoint embedding + LAR group, acupoint embedding + LAR group, capsaicin + LAR group, and tunicamycin + acupoint embedding + LAR group. Behavioral observation, ELISA to detect inflammatory factors in nasal lavage fluid and serum IgE, nasal mucosal permeability test, hematoxylin-eosin staining, PCR to detect Substance P (SP), Western blot, and immunofluorescence to detect endoplasmic reticulum stress (ERS) index and TJs were used to investigate the mechanism of AE in LAR. Results: AE improved the symptoms and pathological features of nasal mucosa of LAR rats, reduced the inflammatory factors (IL4, IL5, IL13) of nasal lavage fluid, and showed no significant change in serum IgE levels in all groups. In addition, AE decreased the expression of SP in nasal mucosa of LAR rats, inhibited ERS, increased the expression of tight junction protein, reduced the permeability of nasal mucosa, and improved the function of nasal mucosal barrier. Conclusion: This study confirms that AE can improve the nasal mucosal barrier function of LAR by reducing the expression of SP, inhibiting ERS and increasing the expression of TJs, thus enhancing the nasal mucosal barrier function.

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It is no skin off my nose

Cited by 4 publications

References 56 publications

Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease

Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease

A Review of Existing and New Treatments for the Management of Hand Eczema

Yingxiang Acupoint Embedding Improves Mucosal Barrier Function in Rats with Local Allergic Rhinitis

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