Istaroxime improves diabetic diastolic dysfunction through SERCA stimulation

Torre, Eleonora; Lodrini, Alessandra Maria; Barassi, Paolo; Ferrandi, Mara; Boz, E.; Bussadori, C.; Ferrari, Paolo; Bianchi, Giuseppe; Rocchetti, Marcella

doi:10.1016/j.acvdsp.2019.02.117

Cited by 1 publication

(1 citation statement)

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“…The decreased protein level of SERCA2a and p16-phospholamban leads to left ventricular diastolic dysfunction and elevated arterial blood pressure [80]. Activation of SERCA can accelerate the reuptake of Ca 2+ by SR, which would improve the diastolic dysfunction of myocardium, and result in strong antiarrhythmic effect [81,82]. Our groups found that the S-glutathiolation of the amino acid residue Cys674 (C674) is key to the increase of the activity in SERCA2 under physiological conditions [83,84], but this post-translational protein modification is prevented by the irreversible oxidation of C674 thiol in pathology hallmarked by high level of ROS, including atherosclerosis, aortic aneurysms, aging and hypertension [83,[85][86][87].…”

Section: Sercamentioning

confidence: 99%

Cross-Talk between Mechanosensitive Ion Channels and Calcium Regulatory Proteins in Cardiovascular Health and Disease

Wang

Shi

Tong

2021

IJMS

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Mechanosensitive ion channels are widely expressed in the cardiovascular system. They translate mechanical forces including shear stress and stretch into biological signals. The most prominent biological signal through which the cardiovascular physiological activity is initiated or maintained are intracellular calcium ions (Ca2+). Growing evidence show that the Ca2+ entry mediated by mechanosensitive ion channels is also precisely regulated by a variety of key proteins which are distributed in the cell membrane or endoplasmic reticulum. Recent studies have revealed that mechanosensitive ion channels can even physically interact with Ca2+ regulatory proteins and these interactions have wide implications for physiology and pathophysiology. Therefore, this paper reviews the cross-talk between mechanosensitive ion channels and some key Ca2+ regulatory proteins in the maintenance of calcium homeostasis and its relevance to cardiovascular health and disease.

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