Ist der Allen-Doisy-Test Spezifisch für das Weibliche Sexualhormon?

Dohrn, Max

doi:10.1007/bf01748034

Cited by 18 publications

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“…Laqueur (1926) and Dohrn (1927) had detected oestrogen activity in the testes. Fee, Marrian & Parkes (1929) as well as Glimm & Wadehn (1930) discussed the possibility of its origin being ingested food, but no conclusion was reached.…”

Section: Origin Of the Urinary Oestrogens In The Malementioning

confidence: 96%

Urinary Oestrogens in the Male

Velle¹

1966

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Oestrogenic activity in urine from males was detected as early as 1927. A few years later mass excretion of oestrogens was detected in the stallion and other equines, and in the boar.The following naturally occurring oestrogens have been chemically identified in urine from males: oestrone (stallion, bull, boar, man, rat), oestradiol-17\g=b\(stallion, boar, man, rat), oestradiol-17\g=a\(stallion, rat), oestriol (man).The levels of oestrogens in male urine is subject to very marked species differences, the stallion showing extremely high levels, followed by other equines and by the domestic boar. During recent years a large number of wild animals has been screened for oestrogens in urine. Generally the values are very low, a few \g=m\g/100 ml of urine, while for stallion's urine the values recorded are in the mg range.The testicular origin of the major part of urinary oestrogens was early anticipated and has been confirmed by recent biochemical investigations. A minor part is probably of adrenal origin.The biological significance of oestrogenic hormones in the male is obscure. Mass secretion of the hormones in males of some species still represents an enigma.The first unequivocal demonstration of the presence of a specific oestrogenic hormone in the mammalian ovary was made about 40 years ago (Allen & Doisy, 1923, 1924. The designation of the substance as the female sex hormone (Frank, 1929) seemed at first to be appropriate, especially since its presence had by then been demonstrated in female blood (Loewe, 1925) and in human pregnancy urine (Aschheim & Zondek, 1927). These original observations pertaining to the female were, however, soon followed by reports of some oestrogen activity also in testes, and in urine from men, indicating that oestrogenic hormones were not entirely sex specific. Then followed the first reports on very high levels of oestrogenic activity in stallion's urine which paradoxically appeared to be one of the richest sources ever found for 'female sex hormones'.Those who have seen a fiery stallion will hardly refute its masculinity. Nevertheless, its daily oestrogen output exceeds that of the non-pregnant female animal by a factor of 100 to 200.Ever since this discovery, the question of how a male may retain its mascu¬ linity in spite of such an enormous oestrogen secretion has remained one of the 65

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Section: Origin Of the Urinary Oestrogens In The Malementioning

confidence: 96%