OBJECTIVE:To determine whether prescription patterns of hormone replacement therapy (HRT) differ in African-American, Asian, Latina, Soviet immigrant, and white women.
DESIGN:Retrospective review of computerized medical records.
SETTING:The general internal medicine, family medicine, and gynecology practices of an academic medical center.
PATIENTS:Women aged 50 years or older with at least one outpatient visit from January 1, 1992, to November 30, 1995.
MEASUREMENTS AND MAIN RESULTS:Use of HRT was defined as documentation of systemic estrogen use. The main predictor variable was self-identified ethnicity. Age, diagnosis (coronary heart disease, hypertension, diabetes, osteoporosis, or breast cancer), and median income were included in the analysis. Of the 8,968 women (mean age, 65.4 years) included, 50% were white, 20% Asian, 15% African American, 9% Latina, and 6% Soviet immigrants. Whites (33%) were significantly more likely to be prescribed HRT than Asians
Studies suggest that the use of postmenopausal hormone replacement therapy (HRT) reduces osteoporotic fractures, 1-7 mortality from coronary heart disease (CHD), 6,8,9 and all-cause mortality. 8,10,11 It increases the risk of endometrial cancer and probably increases the risk of breast cancer. 6,12-15 A recently completed clinical trial showed no overall benefit and some increased risk among women with established CHD randomized to take HRT compared with those taking placebo. 16 The vast majority of women in these studies were white; therefore, little is known about the relation between postmenopausal estrogens and these outcomes in women of color. Similarly, most of the studies that evaluate patterns of use of HRT, physician prescribing patterns for postmenopausal estrogens, or patient or clinician attitudes on HRT either have no data on the ethnicity of the women under consideration or have focused exclusively on white women. [17][18][19][20][21][22][23][24][25][26][27][28][29] Several studies have directly compared rates of HRT use by ethnicity. Two population-based studies found higher rates of HRT use by white women in comparison with nonwhite women. 30,31 Other population-based studies comparing HRT use among African-American and white women have found either no difference or lower rates in African Americans. [32][33][34] Results from studies using clinical samples suggest that African-American women are less likely than white women to be offered or to take HRT. [34][35][36] However, one study from a single academic clinical practice found no differences between 83 AfricanAmerican and 53 white women. 37 The only study to compare HRT use in a multiethnic sample was conducted among women physicians and found that ethnicity was not associated with personal use of HRT. 38 Several studies have evaluated the role of osteoporosis in determining HRT use and prescribing. 19,25,39,40 There is much less information on how other diagnoses, such as hypertension and CHD, affect prescribing patterns for HRT. 41,42 There are no data on the relation between patient r...