Issues in interpreting lipoprotein (a) value as a risk indicator for early cardiovascular disease Sir

Arisaka, Osamu; Kojima, Megumi; Numata, Michio

doi:10.1111/j.1651-2227.2003.tb02492.x

Acta Paediatrica

2003

DOI: 10.1111/j.1651-2227.2003.tb02492.x

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Issues in interpreting lipoprotein (a) value as a risk indicator for early cardiovascular disease Sir

Osamu Arisaka

Megumi Kojima

Michio Numata

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Cited by 3 publications

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“…Many longitudinal cohort studies have demonstrated that childhood obesity and serum lipid abnormalities, including hypercholesterolaemia, are predictive of the development of atherosclerosis and coronary artery disease/myocardial infarction, which can be attributed to long-standing lifestyle practices [1][2][3][4]. Although various risk factors for atherosclerosis have already been confirmed, more recent studies have shown that small, dense low-density lipoproteins (LDL) with particle diameters 525.5 nm contribute significantly to the pathogenesis of coronary artery disease [5][6][7][8].…”

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Association of low-density lipoprotein particle size distribution and cardiovascular risk factors in children

et al. 2005

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confidence: 99%

Association of low-density lipoprotein particle size distribution and cardiovascular risk factors in children

et al. 2005

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Association of low-density lipoprotein particle size distribution and cardiovascular risk factors in children

et al. 2005

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High Density Lipoprotein Particle Size in Children: Relation to Atherogenic Dyslipidemia

Numata

2004

Clin Pediatr Endocrinol

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Atherosclerosis begins in childhood. Protection from atherosclerosis is provided by high-density lipoprotein (HDL), a heterogeneous particle, which includes several subclasses differing in size, density and apolipoprotein content. The objective of this study was to document the relevance of assessing HDL particle size as another feature of dyslipidemia related to the develpment of atheosclerosis during childhood. For that purpose, HDL particle size in 268 community-based children (137 boys and 131 girls), 7–13 years old, was measured by gradient gel electrophoresis, and relationships of HDL particle size to plasma lipids parameters and the anthropometric indices were analyzed. There was no gender difference in HDL particle diameter. The results of analysis revealed significant positive correlations between HDL particle diameter and HDL-cholesterol level (r=0.363, p<0.01), apolipoprotein AI level (r=0.310, r<0.05) and low-density lipoprotein particle (LDL) size (r=0.290, p<0.05), while there was an inverse correlation with atherogenic index (r=–0.316, p<0.05). There was no significant correlation between HDL particle size and triglyceride levels in the overall analysis (n=268), however, when this relation was analyzed in the limited HDL size range below 11 nm, a significant inverse relation appeared between particle size and TG levels (r =–0.546, P<0.01, n=75). These findings indicate that the general shift toward smaller HDL particle size was associated with dyslipidemia characterized by higher atherogenic index and triglyceride level, lower HDL-C level and smaller LDL particle size. Therefore, HDL size may represent another relevant marker of atherogenic lipid metabolism.

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Issues in interpreting lipoprotein (a) value as a risk indicator for early cardiovascular disease Sir

Cited by 3 publications

References 8 publications

Association of low-density lipoprotein particle size distribution and cardiovascular risk factors in children

Association of low-density lipoprotein particle size distribution and cardiovascular risk factors in children

Association of low-density lipoprotein particle size distribution and cardiovascular risk factors in children

High Density Lipoprotein Particle Size in Children: Relation to Atherogenic Dyslipidemia

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