Issues and pitfalls in method comparison studies

Hartnack, Sonja

doi:10.1111/vaa.12143

Cited by 21 publications

(12 citation statements)

References 21 publications

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“…As the number of repeat measures per individual was not constant (due to availability and exercise regime of the animals) and the repeated measures were taken on different days and under different environmental conditions (resulting in variable resting body temperatures), the use of a Bland-Altman plot was deemed inappropriate (Hartnack, 2014). A scatter plot was instead used to provide a visual assessment of the difference between the two sites.…”

Section: Discussionmentioning

confidence: 99%

Comparison of rectal and tympanic membrane temperature in healthy exercising dogs

Hall

Carter

2017

CEP

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Running header:Comparison of rectal and tympanic membrane temperature in exercising dogs. AbstractThe ability to monitor body temperature in athletes at risk of hyperthermia is essential in all species. Currently, the only commonly accepted temperature monitoring site in dogs is the rectum. This is impractical in field situations as it takes time, requires additional handlers to restrain the dog and is not tolerated by all animals. Tympanic membrane temperature (TMT) monitoring may provide a rapid measure of body temperature to facilitate identification of heat stress and heat stroke in canine athletes. In human studies, TMT diverges from rectal temperature (RT) as body temperature increases during exercise induced hyperthermia so is not recommended for monitoring human athletes. If the same divergence occurs in dogs, TMT may not be suitable for use when monitoring the temperature of canine athletes.The aim of the study was to determine if TMT diverged from RT following exercise in healthy dogs. 24 healthy dogs were recruited to the study. Body temperature was measured using a veterinary auricular infrared thermometer (VetTemp) to record tympanic membrane temperature and an electric predictive rectal thermometer. Temperatures were recorded pre and post exercise in a non-clinical setting, familiar to the dogs.The mixed model approach showed that exercise had no effect on the difference between RT and TMT (F(1,201) =0.026, P=0.872). The overall mean difference of RT minus TMT was 0.39°C (n = 116). 68.4% of readings fell within the accepted 0.5°C difference in temperature recording method.In line with previously reported TMT to RT comparison studies in dogs, this study found that TMT measured consistently lower than RT. Using a correction factor of 0.4°C minimised the difference. The hypothesis that dogs would show greater differences between TMT and RT following exercise was not supported, suggesting that TMT could be used to monitor body temperature in exercising dogs where RT is not possible.

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Section: Discussionmentioning

confidence: 99%

Comparison of rectal and tympanic membrane temperature in healthy exercising dogs

Hall

Carter

2017

CEP

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“…Weiterhin werden die "limits of agreement" (loa) angegeben, welche die systematische Messabweichung von ±1,96×Standardabweichung angeben. Sie zeigen, wie weit voneinander entfernt die Ergebnisse der Messmethoden sind (Hartnack 2014 …”

Section: Einführungunclassified

Evaluation of tidal volume measurements of the anaesthesia device Tafonius® in vitro and in vivo

Kobler

Hartnack

Sacks

et al. 2016

PHK

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The anaesthesiologic risk is higher in horses than in other domesticated animal species and thereby ventilation is a vital problem. The aim of this study was to evaluate the accuracy of the anaesthesia device Tafonius ® tidal volume measurements in vitro as well as in vivo. In an in vitro study the whole system was flushed by air to reduce the air moisture to a minimum. The preparation of the anaesthesia device was exactly the same, as if there was a surgery on a patient. But instead of a horse, a seven liter calibration syringe was connected to the Y-piece of the anaesthesia device and the whole system was flooded by pure oxygen. By touch screen on the monitor of the anaesthesia device, a CPAP (Continuous Positive Airway Pressure), a tidal volume of 20 liters and an airway pressure of 20 cmH 2 O were adjusted. The leakage test was repeated and the connections tightened until the leak was 168 mL gas per minute. All the measurements were made randomly, without breaks or changes of the adjustments. For tidal volume measurements a seven liter calibration syringe was used. A connecting piece was specially manufactured, to attach the syringe to the Tafonius ® without gas leakage.14 different tidal volumes were evaluated in a random order, covering the range from 500 mL to 7000 mL using 500 mL steps. To imitate respiration during anaesthesia, three respiratory rates were simulated: 30, 15 and 6 times per minute. All the measurements were performed in duplicate, once with NICO ® interconnected and once without it. The respiratory rates and tidal volumes were chosen in random order, as well as whether the flow meter was interconnected or not. In a in vivo study twenty-one patients with a mean weight of 516 kilograms submitted for elective surgery were included. All of them received a balanced anaesthesia regime (inhalation anaesthesia with isoflurane and constant rate infusion with medetomidine (3.5 mcg/kg/h) and controlled mechanical ventilation. 16 horses were positioned in dorsal and five in lateral recumbency. The flow meter NICO ® was connected ones a steady state in the plane of anaesthesia was reached. The flow meter was left during 38 to 190 breaths. A total of 2368 breaths were measured. Mean tidal volumes reached from 4107 mL to 8964 mL. In vitro data were analysed by descriptive statistics to determine measurement accuracy. Bland-Altman plots with limits of agreement (loa) were used to analyze in vivo data. The mean difference between the volume given by the calibration syringe and the volume shown on the Tafonius ® screen was -19.45 % (standard deviation 11%). The data stored on the computer showed an average difference of -20.5 % (standard deviation 15.57 %). Whether NICO ® was interconnected or not resulted in a change in accuracy of 0.36 % in the volume measurement of the Tafonius ® . The mean difference of the volume produced with the calibration syringe and the measured volume of the NICO ® was 0.73 % (standard deviation 4.3 %). The Bland-Altman analysis from NICO ® to Tafonius ® gave a lower limit of a...

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“…More recent studies [11][12][13][14] draw conclusions based on mean bias and limits of agreement between invasive and noninvasive blood pressure (NIBP) measurement techniques. A recent perspective paper [15] argues against the use of classic Bland-Altman plots and linear regression, and for the use of linear mixed effects models as a method to compare measurement techniques.…”

Section: Introductionmentioning

confidence: 99%

Equivalence between invasive and oscillometric blood pressures at different anatomic locations in healthy normotensive anaesthetised horses

Tearney

Guedes

Brosnan

2015

Equine Veterinary Journal

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Issues and pitfalls in method comparison studies

Cited by 21 publications

References 21 publications

Comparison of rectal and tympanic membrane temperature in healthy exercising dogs

Comparison of rectal and tympanic membrane temperature in healthy exercising dogs

Evaluation of tidal volume measurements of the anaesthesia device Tafonius® in vitro and in vivo

Equivalence between invasive and oscillometric blood pressures at different anatomic locations in healthy normotensive anaesthetised horses

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