Issue 1 - “Update on adverse respiratory effects of outdoor air pollution” Part 2): Outdoor air pollution and respiratory diseases: Perspectives from Angola, Brazil, Canada, Iran, Mozambique and Portugal

Sousa, Ana Carolina Andrade de; Pastorinho, M. Ramiro; Masjedi, Mohamed R.; Urrutia-Pereira, Marylin; Arrais, Margarete; Nunes, Elizabete; To, Teresa; Ferreira, António Jorge; Cordeiro, Carlos Robalo; Borrego, Carlos; Teixeira, João Paulo; Taborda-Barata, Luís

doi:10.1016/j.pulmoe.2021.12.007

Cited by 15 publications

(4 citation statements)

References 96 publications

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“…However, Bragança firefighters had 5-times higher median 1-OHPyr levels than those from Carrazeda de Ansiães ( Supplementary Figure S1 ). Despite the Portuguese inland districts such as Bragança having less intense traffic than those on the coastline ( 106 , 107 ), the city of Bragança has a higher population density and far more trafficked roads (i.e., inside 2 km radius from the fire station there are four national roads and one main itinerary) than Carrazeda de Ansiães. Indeed, some studies have identified an increase in PM 10 and PM 2.5 air concentrations in Bragança due to traffic pollution ( 108 , 109 ).…”

Section: Discussionmentioning

confidence: 99%

Baseline data and associations between urinary biomarkers of polycyclic aromatic hydrocarbons, blood pressure, hemogram, and lifestyle among wildland firefighters

Barros,

Paiva,

Oliveira

et al. 2024

Front. Public Health

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IntroductionAvailable literature has found an association between firefighting and pathologic pathways leading to cardiorespiratory diseases, which have been linked with exposure to polycyclic aromatic hydrocarbons (PAHs). PAHs are highlighted as priority pollutants by the European Human Biomonitoring Initiative in occupational and non-occupational contexts.MethodsThis cross-sectional study is the first to simultaneously characterize six creatinine-adjusted PAHs metabolites (OHPAHs) in urine, blood pressure, cardiac frequency, and hemogram parameters among wildland firefighters without occupational exposure to fire emissions (> 7 days), while exploring several variables retrieved via questionnaires.ResultsOverall, baseline levels for total OHPAHs levels were 2 to 23-times superior to the general population, whereas individual metabolites remained below the general population median range (except for 1-hydroxynaphthalene+1-hydroxyacenaphtene). Exposure to gaseous pollutants and/or particulate matter during work-shift was associated with a 3.5-fold increase in total OHPAHs levels. Firefighters who smoke presented 3-times higher total concentration of OHPAHs than non-smokers (p < 0.001); non-smoker females presented 2-fold lower total OHPAHs (p = 0.049) than males. 1-hydroxypyrene was below the recommended occupational biological exposure value (2.5 μg/L), and the metabolite of carcinogenic PAH (benzo(a)pyrene) was not detected. Blood pressure was above 120/80 mmHg in 71% of subjects. Firefighters from the permanent intervention team presented significantly increased systolic pressure than those who performed other functions (p = 0.034). Tobacco consumption was significantly associated with higher basophils (p = 0.01–0.02) and hematocrit (p = 0.03). No association between OHPAHs and blood pressure was found. OHPAHs concentrations were positively correlated with monocyte, basophils, large immune cells, atypical lymphocytes, and mean corpuscular volume, which were stronger among smokers. Nevertheless, inverse associations were observed between fluorene and pyrene metabolites with neutrophils and eosinophils, respectively, in non-smokers. Hemogram was negatively affected by overworking and lower physical activity.ConclusionThis study suggests possible associations between urinary PAHs metabolites and health parameters in firefighters, that should be further assessed in larger groups.

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Section: Discussionmentioning

confidence: 99%

Baseline data and associations between urinary biomarkers of polycyclic aromatic hydrocarbons, blood pressure, hemogram, and lifestyle among wildland firefighters

Barros,

Paiva,

Oliveira

et al. 2024

Front. Public Health

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“…Besondere Aufmerksamkeit sollte den allgegenwärtigen Umwelteinflüssen gewidmet werden, die nach Angaben der WHO weltweit für 13 Millionen vorhersehbare Todesfälle pro Jahr verantwortlich sind, darunter mehr als 7 Millionen Menschen, die jedes Jahr an den Folgen der Luftverschmutzung sterben [40]. In der Tat sollten alle Ärzte, die chronische Atemwegspatienten behandeln, die Bedeutung der Luftverschmutzung auch für die interessierenden harten Behandlungsergebnisse kennen [27] und das Problem sowohl auf der Ebene der Arzt-Patienten-Beziehung als auch auf der Ebene der Gesellschaft als Verfechter sauberer Luft behandeln [41–43].…”

Section: Diskussionunclassified

COPD-Behandlung – eine konzeptionelle Überprüfung auf der Grundlage kritischer Endpunkte

Roque,

Tarboda-Barata,

Cruz

et al. 2023

Kompass Pneumol

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Einleitung: Die chronisch-obstruktive Lungenerkrankung (COPD) ist weltweit eine der Hauptursachen für Tod und Behinderung. Inzwischen gibt es zahlreiche Behandlungsmöglichkeiten, aber die Kriterien für die Auswahl inhalativer Bronchodilatatoren und inhalativer Kortikosteroide sind weiterhin in der Diskussion. Neue Studien haben die Rolle von Patientencharakteristika wie Eosinophilenzahl und Exazerbationsverlauf bei der Auswahl der wirksamsten personalisierten Behandlungsoption hervorgehoben. Methoden: In dieser konzeptionellen Übersichtsarbeit wird eine ausführliche Begründung mit einem integrativen Ansatz für die COPD-Behandlung entwickelt, wobei Daten aus den wichtigsten bisher durchgeführten klinischen Studien gesammelt werden, die die aktuellen GOLD-2023-Empfehlungen unterstützen können. Ergebnisse: Je nach Charakteristika und Profil des Patienten werden verschiedene Behandlungsoptionen, darunter Mono-, Zweifach- und Dreifachtherapien, in einer Diagrammmatrix dargestellt und ihre Wirksamkeit in Bezug auf die Verringerung von Exazerbationen und des Sterberisikos verglichen.

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“…Protection is very difficult due to the different particle sizes of harmful substances (Figure 1). Fine particulate matter (PM2.5) is particularly concerning as it can penetrate deep into the lungs and even enter the bloodstream, causing systemic inflammation [18]. Various research results have demonstrated the connection between air pollution and cardiovascular diseases (CVDs), such as heart attack, stroke, and high blood pressure [19].…”

Section: Introductionmentioning

confidence: 99%

“…temic inflammation [18]. Various research results have demonstrated the connection between air pollution and cardiovascular diseases (CVDs), such as heart attack, stroke, and high blood pressure [19].…”

Section: Introductionmentioning

confidence: 99%

Personalized Nasal Protective Devices: Importance and Perspectives

Quoc,

Bácskay,

Fehér

et al. 2023

Life

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Nowadays, in addition to diseases caused by environmental pollution, the importance of personalized protection against various infectious agents has become of paramount importance. Besides medicine, several technical and technological studies have been carried out to develop suitable devices. One such revolutionary solution is the use of personalized nasal filters, which allow our body to defend itself more effectively against external environmental damage and pathogens. These filters are small devices that are placed in the nose and specifically filter the inhaled environmental contaminants, allergens, and microorganisms according to individual needs. These devices not only play a key role in maintaining our health but also contribute to environmental protection, reducing the inhalation of pollutants and their harmful impact on the natural environment. Another advantage of personalized filters is that they also provide an opportunity to strengthen our individual immune systems. The use of personalized filters allows medicine to provide optimized protection for everyone, focusing on individual genetic and immunological conditions. The momentum behind the development and research of personalized nasal filters has reached astonishing proportions today. Nowadays, many research groups and medical institutions are working to create new materials, nanotechnologies, and bioinformatics solutions in order to create even more effective personalized nasal filters that can also be shaped easily and safely. Considering the needs of the users is at least as important during development as the efficiency of the device. These two properties together determine the success of the product. Industry research focuses not only on improving the efficiency of devices, but also on making them more responsive to user needs, comfort, and portability. Based on all this, it can be concluded that personalized nasal filters can be a promising and innovative solution for protection against environmental pollutants and pathogens. Through a commitment to the research and development of technology, the long-term impact of such devices on our health and the environment can be significant, contributing to improving people’s quality of life and creating a sustainable future. With unique solutions and continuous research, we give hope that in the future, despite the environmental challenges, we can enjoy the protection of our health with even more efficient and sophisticated devices.

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Issue 1 - “Update on adverse respiratory effects of outdoor air pollution” Part 2): Outdoor air pollution and respiratory diseases: Perspectives from Angola, Brazil, Canada, Iran, Mozambique and Portugal

Cited by 15 publications

References 96 publications

Baseline data and associations between urinary biomarkers of polycyclic aromatic hydrocarbons, blood pressure, hemogram, and lifestyle among wildland firefighters

Baseline data and associations between urinary biomarkers of polycyclic aromatic hydrocarbons, blood pressure, hemogram, and lifestyle among wildland firefighters

COPD-Behandlung – eine konzeptionelle Überprüfung auf der Grundlage kritischer Endpunkte

Personalized Nasal Protective Devices: Importance and Perspectives

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