ISSLS PRIZE IN CLINICAL SCIENCE 2019: clinical importance of trunk muscle mass for low back pain, spinal balance, and quality of life—a multicenter cross-sectional study

Hori, Yusuke; Hoshino, Minoru; Inage, Kazuhide; Miyagi, Masayuki; Takahashi, Shinji; Ohyama, Shoichiro; Suzuki, Akinobu; Tsujio, Tadao; Terai, Hidetomi; Dohzono, Sho; Sasaoka, Ryuichi; Toyoda, Hiromitsu; Kato, Minori; Matsumura, Akira; Namikawa, Takashi; Seki, Mitsunori; Yamada, Kentaro; Habibi, Hasibullah; Salimi, Hamidullah; Yamashita, Masaomi; Yamauchi, Tomonori; Furuya, Takeo; Orita, Sumihisa; Maki, Satoshi; Shiga, Yasuhiro; Inoue, Masahiro; Inoue, Gen; Fujimaki, Hisako; Murata, Kei; Kawakubo, Ayumu; Kabata, Daijiro; Shintani, Ayumi; Ohtori, Seiji; Takaso, Masashi; Nakamura, Hiroaki

doi:10.1007/s00586-019-05904-7

Cited by 62 publications

(35 citation statements)

References 28 publications

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“…This may be because individuals with LBP sometimes reduce their levels of physical activity, which leads to physical deconditioning, including functional changes of the trunk. A recent study indicated that trunk muscle mass was associated with LBP disability 43. Additionally, our results may indicate that individuals with LBP continue to have the risk factors responsible for the initial occurrence of LBP.…”

Section: Discussionsupporting

confidence: 51%

Factors associated with disabling low back pain among nursing personnel at a medical centre in Japan: a comparative cross-sectional survey

et al. 2019

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ObjectivesLow back pain (LBP) is a common cause of disability among nursing personnel. Although many studies regarding the risk factors for LBP among nursing staff have focused on the physical load at work, multidimensional assessments of risk factors are essential to identify appropriate preventive strategies. We aimed to investigate the association of multidimensional factors (individual, physical, psychological and occupational) with disabling LBP among nursing personnel in Japan.DesignObservational study with comparative cross-sectional design.SettingData were collected using the self-administered questionnaire at a tertiary medical centre.ParticipantsAfter excluding participants with missing variables, 718 nursing personnel were included in the analysis.Outcome measuresA self-administered questionnaire assessed individual characteristics, rotating night shift data, severity of LBP, previous episode of LBP, sleep problem, kinesiophobia (Tampa Scale for Kinesiophobia), depressive condition (K6), physical flexibility and frequency of lifting at work. A logistic regression model was used to evaluate the factors associated with disabling LBP (LBP interfering with work) among nursing personnel.ResultsOf all participants, 110 (15.3%) reported having disabling LBP. The multivariable logistic regression analysis after adjustment for several confounding factors showed that kinesiophobia (highest tertile, adjusted OR (aOR): 6.13, 95% CI : 3.34 to 11.27), previous episode of LBP (aOR: 4.31, 95% CI: 1.50 to 12.41) and insomnia (aOR: 1.66, 95% CI: 1.05 to 2.62) were significantly associated with disabling LBP.ConclusionsThe present study indicated that kinesiophobia, a previous episode of LBP, and sleep problems were associated with disabling LBP among nursing personnel. In the future, workplace interventions considering assessments of these factors may reduce the incidence of disabling LBP in nursing staff, although further prospective studies are needed.

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Section: Discussionsupporting

confidence: 51%

Factors associated with disabling low back pain among nursing personnel at a medical centre in Japan: a comparative cross-sectional survey

et al. 2019

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“…A decrease in trunk muscle mass and the degeneration of back muscles were reported to be associated with lower back pain 25,26 . However, the diagnostic criteria for sarcopenia did not include the assessment of either trunk muscle mass or back muscle degeneration; rather, it included assessment of the appendicular skeletal muscle mass 20 .…”

Section: Discussionmentioning

confidence: 99%

Presence of sarcopenia does not affect the clinical results of balloon kyphoplasty for acute osteoporotic vertebral fracture

Ohyama

Hoshino

Takahashi

et al. 2021

Sci Rep

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Sarcopenia has been associated with poor clinical outcomes in several diseases. Herein, the clinical results of balloon kyphoplasty (BKP) for acute osteoporotic vertebral fracture (OVF) treatment were assessed and compared between sarcopenia and non-sarcopenia patients. Sixty patients who underwent BKP for treatment of acute OVF with poor prognostic factors between April 2016 and September 2017 and were assessed for sarcopenia were enrolled. Clinical results (back pain on visual analogue scale [VAS]; short-form [SF] 36; vertebral deformity; activities of daily living levels; and incidence of adjacent vertebral fractures) were compared between the two groups at 6 months post-BKP. Data analysis revealed that back pain on VAS, SF-36 scores, and vertebral deformity improved from baseline to 6 months after BKP. Thirty-nine patients (65.0%) were diagnosed with sarcopenia and demonstrated a lower body mass index (21.2 vs. 23.3 kg/m2, p = 0.02), skeletal muscle mass index (5.32 vs. 6.55 kg/m2, p < 0.01), hand-grip strength (14.7 vs. 19.2 kg, p = 0.01), and bone mineral density of the femoral neck (0.57 vs. 0.76 g/cm2, p < 0.01) than those of patients without sarcopenia. However, no significant differences were observed in the clinical results between these groups. Therefore, BKP’s clinical results for the treatment of acute OVF are not associated with sarcopenia.

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“…Intervertebral disc degeneration (IDD) is a widespread condition in the aging population, frequently triggered by premature senescence and dysfunction of intervertebral disc cells [1]. Because of the pivotal role of intervertebral discs in supporting the normal function of the vertebro-spinal axis [2], disc degeneration can accelerate normal spinal aging and cause severe neck and back pain [3]. Following terminal differentiation, cells in high-load structures such as intervertebral discs face higher senescent stress than cells in other motor organs; factors at play include cell aging, stem cell depletion, and protein homeostasis imbalances, among others [4].…”

Section: Introductionmentioning

confidence: 99%

Bone marrow-derived mesenchymal stem cells in three-dimensional co-culture attenuate degeneration of nucleus pulposus cells

Han

et al. 2019

Aging

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Intervertebral disc degeneration (IDD) is an irreversible aging-associated clinical condition of unclear etiology. Mesenchymal stem cells (MSCs) have the potential to delay IDD, but the mechanisms by which MSCs attenuate senescence-related degeneration of nucleus pulposus cells (NPCs) remain uncertain. The present study employed a three-dimensional (3D) co-culture system to explore the influence of MSCs on NPC degeneration induced by TNF-α in rat cells. We found that co-culture with bone marrow-derived MSCs (BMSCs) reduced senescence-associated β-galactosidase expression, increased cell proliferation, decreased matrix metalloproteinase 9, increased Coll-IIa production, and reduced TGFβ/NF-κB signaling in senescent NPCs. In addition, expression of zinc metallopeptidase STE24 (ZMPSTE24), whose dysfunction is related to premature cell senescence and aging, was decreased in senescent NPCs but restored upon BMSC co-culture. Accordingly, ZMPSTE24 overexpression in NPCs inhibited the pro-senescence effects of TGFβ/NF-κB activation upon TNF-α stimulation, while both CRISPR/Cas9-mediated silencing and pharmacological ZMPSTE24 inhibition prevented those effects. Ex-vivo experiments on NP explants provided supporting evidence for the protective effect of MSCs against NPC senescence and IDD. Although further molecular studies are necessary, our results suggest that MSCs may attenuate or prevent NP fibrosis and restore the viability and functional status of NPCs through upregulation of ZMPSTE24.

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ISSLS PRIZE IN CLINICAL SCIENCE 2019: clinical importance of trunk muscle mass for low back pain, spinal balance, and quality of life—a multicenter cross-sectional study

Cited by 62 publications

References 28 publications

Factors associated with disabling low back pain among nursing personnel at a medical centre in Japan: a comparative cross-sectional survey

Factors associated with disabling low back pain among nursing personnel at a medical centre in Japan: a comparative cross-sectional survey

Presence of sarcopenia does not affect the clinical results of balloon kyphoplasty for acute osteoporotic vertebral fracture

Bone marrow-derived mesenchymal stem cells in three-dimensional co-culture attenuate degeneration of nucleus pulposus cells

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