Isovitexin Increases Stem Cell Properties and Protects Against PM2.5 in Keratinocytes

Chowjarean, Verisa; Prueksasit, Tassanee; Joyjamras, Keerati; Chanvorachote, Pithi

doi:10.21873/invivo.11676

Cited by 10 publications

(7 citation statements)

References 29 publications

(30 reference statements)

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“…The toxicity of vitexin and its derivatives have been observed by (1) studies in vitro using cells or cell lines and (2) in vivo experimentation in animal models. The cytotoxicity of vitexin and isovitexin has been assessed in human leukemia CCRF-CEM cells [ 206 ], macrophages cells (RAW264.7) [ 134 , 207 ], T lymphocytes and RBL-2H3-mast cells [ 99 ], N9 microglial cells [ 74 ], neutrophils [ 106 ], breast carcinoma cell lines, either T47D or MCF-7 [ 203 ], MCF-7, A549, HepG2, and HT-29 cells [ 208 ], HepG2 cells [ 209 ], J774 macrophages cells [ 139 ], and human keratinocyte (HaCaT) cells [ 144 ], and they only exerted negligible to no cytotoxic effects. In addition, vitexin-2″-O-rhamnoside and vitexin-4″-O-glucoside caused no cytotoxic effect on human adipose-derived stem cells, A2780 and MCF-7cells [ 210 , 211 ].…”

Section: Resultsmentioning

confidence: 99%

“…Vitexin and isovitexin DPPH radical scavenging activity is suggested to be attributed to the phenolic hydroxyl group in the 4′ position on the B-ring [33,38,143,146,[148][149][150][151][152][153][154][155][156][157]. Moreover, isovitexin-6″-O-α-L-glucoside, vitexin, vitexin-2″-Orhamnoside, and isovitexin demonstrated moderate to high affinity to generated free ABTS•+ in the ABTS assay [44,[141][142][143][144][145][156][157][158][159][160][161][162]. In superoxide radical-scavenging assay, isovitexin and vitexin showed a protective effect against the oxidative-induced reactions by scavenging generated free superoxide anion radicals [37,133,147,150,156,163,164].…”

Section: Reactive Speciesmentioning

confidence: 99%

“…e Scientific World Journal absorbance, the more potent the antioxidant activity of the compound in terms of hydrogen donating ability [140]. [128,132,[141][142][143][144][145][146][147]. Vitexin and isovitexin DPPH radical scavenging activity is suggested to be attributed to the phenolic hydroxyl group in the 4′ position on the B-ring [33,38,143,146,[148][149][150][151][152][153][154][155][156][157].…”

Section: Reactive Speciesmentioning

confidence: 99%

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Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications

Abdulai

Kwofie

Gbewonyo

et al. 2021

The Scientific World Journal

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Background. Till date, there is no known antidote to cure diabetes mellitus despite the discovery and development of diverse pharmacotherapeutic agents many years ago. Technological advancement in natural product chemistry has led to the isolation of analogs of vitexin and isovitexin found in diverse bioresources. These compounds have been extensively studied to explore their pharmacological relevance in diabetes mellitus. Aim of the Study. The present review was to compile results from in vitro and in vivo studies performed with vitexin and isovitexin derivatives relating to diabetes mellitus and its complications. A systematic online literature query was executed to collect all relevant articles published up to March 2020. Results. In this piece, we have collected data and presented it in a one-stop document to support the multitargeted mechanistic actions of vitexin and isovitexin in controlling diabetes mellitus and its complications. Conclusion. Data collected hint that vitexin and isovitexin work by targeting diverse pathophysiological and metabolic pathways and molecular drug points involved in the clinical manifestations of diabetes mellitus. This is expected to provide a deeper understanding of its actions and also serve as a catapult for clinical trials and application research.

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Section: Resultsmentioning

confidence: 99%

Section: Reactive Speciesmentioning

confidence: 99%

Section: Reactive Speciesmentioning

confidence: 99%

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Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications

Abdulai

Kwofie

Gbewonyo

et al. 2021

The Scientific World Journal

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“…Niacinamide, a compound that is often used in various cosmetics, was shown to protect keratinocytes from PMinduced oxidative stress [184]. Other reducing agents found to protect the skin against PM are 3,4-dicaffeoylquinic acid [186], 7,3′,4′-trihydroxyisoflavone cyclodextrin inclusion complex [142], isovitexin [176], ginsenoside Rb1 [175], chitosan [259], and SIG-1273, a isoprenylcysteine small molecule [228].…”

Section: Protective Solutions Against Pm-induced Skin Damagementioning

confidence: 99%

Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies

Dijkhoff¹,

Drašler²,

Karakoçak³

et al. 2020

Part Fibre Toxicol

115

116

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Background: Air pollution is killing close to 5 million people a year, and harming billions more. Air pollution levels remain extremely high in many parts of the world, and air pollution-associated premature deaths have been reported for urbanized areas, particularly linked to the presence of airborne nano-sized and ultrafine particles. Main text: To date, most of the research studies did focus on the adverse effects of air pollution on the human cardiovascular and respiratory systems. Although the skin is in direct contact with air pollutants, their damaging effects on the skin are still under investigation. Epidemiological data suggested a correlation between exposure to air pollutants and aggravation of symptoms of chronic immunological skin diseases. In this study, a systematic literature review was conducted to understand the current knowledge on the effects of airborne particulate matter on human skin. It aims at providing a deeper understanding of the interactions between air pollutants and skin to further assess their potential risks for human health. Conclusion: Particulate matter was shown to induce a skin barrier dysfunction and provoke the formation of reactive oxygen species through direct and indirect mechanisms, leading to oxidative stress and induced activation of the inflammatory cascade in human skin. Moreover, a positive correlation was reported between extrinsic aging and atopic eczema relative risk with increasing particulate matter exposure.

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“…Over recent years, researchers have attempted to prevent and control the cellular and organ damage caused by PM2.5. Some researchers have shown that some natural compounds, and traditional Chinese medicines, can protect the cell and organ damage induced by PM2.5 both in vitro and in vivo, including isovitexin [21], astaxanthin [22], curcumin [23], astragalus [24], codonopsis pilosula [24], ophiopogonin [25], triptolide [26], astragaloside IV [27], resveratrol [28], and lentinan [29]. All of these studies were carried out in vivo; drugs were administered systematically, by either oral or injection routes.…”

Section: Discussionmentioning

confidence: 99%

Inhalation of Salvianolic acid B Prevents Fine Particulate Matter-Induced Acute Airway Inflammation and Oxidative Stress by Downregulating the LTR4/MyD88/NLRP3 Pathway

Li¹,

Kan²,

Xie³

2021

Preprint

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Background: Air pollution is a serious threat to human health. Inhaled fine particulate matter (PM2.5) can cause inflammation and oxidation in the airway; however, the mechanisms responsible for this effect have yet to be elucidated and there are no specific drugs that can prevent and treat this condition. In the present study, we investigated the effects and mechanisms underlying the inhalation of salvianolic acid B (SalB) on PM2.5-induced airway inflammation and oxidation.Methods: We used a PM2.5-induced mouse model of airway inflammation and oxidation, along with a human epithelial cell model, to study the action and mechanisms of SalB by histopathology, real-time quantitative polymerase chain reaction, enzyme-linked immunosorbent assays, flow cytometry, and western blotting. Results: SalB treatment markedly inhibited the PM2.5-induced increase in the number of neutrophils and macrophages in bronchoalveolar lavage fluid, improved the infiltration of inflammatory cells in lung tissue, and reduced injury in the alveolar septum. Furthermore, SalB reduced the mRNA and protein levels of interleukin (IL)-1β, tumor necrosis factor (TNF)-α, keratinocyte (KC), and transforming growth factor (TGF)-β1 in lung tissues, and the protein levels of IL-1β, TNF-α, IL-8, IL-6 and TGF-β1 in human epithelial cells. SalB treatment also significantly reversed the reduction of levels of superoxide dismutase, catalase, glutathione and glutathione peroxidase in lung tissue and reduced the levels of reactive oxygen species in human epithelial cells induced by PM2.5. Furthermore, SalB and the myeloid differentiation primary response 88 (MyD88) inhibitor ST2825, inhibited the expression levels of toll-like receptor 4 (TLR4), MyD88, tumor necrosis factor receptor associated factor 6 (TRAF-6), and NOD-like receptor protein 3 (NLRP3), as well as the phosphorylation of downstream signals extracellular signal regulated kinase 1/2 (Erk1/2) and P38 MAP kinase (P38) in lung tissue and epithelial cells.Conclusion: SalB protects against PM2.5-induced airway inflammation and oxidation in a manner that is associated with the inhibition of the TLR4/MyD88/TRAF-6/NLRP3 pathway and downstream signals ERK1/2 and P38.

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Isovitexin Increases Stem Cell Properties and Protects Against PM2.5 in Keratinocytes

Cited by 10 publications

References 29 publications

Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications

Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications

Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies

Inhalation of Salvianolic acid B Prevents Fine Particulate Matter-Induced Acute Airway Inflammation and Oxidative Stress by Downregulating the LTR4/MyD88/NLRP3 Pathway

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