Isotypic Analysis of Grass-Pollen-Specific Immunoglobulins in Human Plasma

Batard, Thierry; Basuyaux, B.; Laroze, Alain; Lambin, P.; Bremard-Oury, C.; Aucouturier, Pièrre; Hamilton, Robert G.; David, B.; Peltre, Gabriel

doi:10.1159/000236537

Cited by 13 publications

(4 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The earliest recognition of IgG4 in allergies was from Allergen-specific immunotherapy (AIT) data, demonstrating a tolerance-inducing function (14)(15)(16). However, later clinical observations revealed that allergen-specific IgG4 was associated with allergic sensitization and correlated to allergic diseases, such as allergic rhinitis (AR), asthma, atopic dermatitis (AD), and anaphylaxis (17)(18)(19)(20)(21)(22)(23). IgG4 levels may vary significantly in healthy individuals (24), strongly hindering its clinical application as a diagnostic tool.…”

Section: Introductionmentioning

confidence: 99%

The clinical significance of allergen-specific IgG4 in allergic diseases

Tang

Liu

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

IgG4 is a subclass of IgG antibody with a unique molecular feature of (Fragment antigen- binding) Fab-arm exchange, allowing bispecific antigen binding in a mono-valent manner. With low binding affinity to C1q and Fcγreceptors, IgG4 is incapable of forming immune complexes and activating the complement pathway, exhibiting a non-inflammatory feature. IgG4 is produced similarly to IgE and is considered a modified reaction to IgE class-switching response under certain conditions. It could also counteract IgE-activated inflammation. However, the clinical significance of IgG4 in allergic diseases is complex and controversial. Three viewpoints have been suggested to describe the role of IgG4. IgG4 can act as a tolerance–inducer to play a protective role under repeated and rapid incremental dosing of allergen exposure in allergen immunotherapy (AIT), supported by allergies in cat raisers and venom desensitization in beekeepers. Another viewpoint accepted by mainstream specialists and guidelines of Food Allergy and Management in different countries points out that food-specific IgG4 is a bystander in food allergy and should not be used as a diagnostic tool in clinical work. However, eosinophilic esophagitis (EoE) investigation revealed a direct clinical relevance between physiopathology and serum IgG4 in cow milk and wheat. These factors indicate that allergen-specific IgG4 plays a multifaceted role in allergic diseases that is protective or pathogenic depending on different allergens or exposure conditions.

show abstract

Section: Introductionmentioning

confidence: 99%

The clinical significance of allergen-specific IgG4 in allergic diseases

Tang

Liu

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…Aside from the clinical implications, aeroallergens are non-infectious environmental antigens to which most people will mount a minimal T-cell-dependent and allergen-specific humoral response involving the IgA and IgG isotype classes [5, 6]. We have shown that atopic and non-atopic humans can mount equally vigorous humoral responses to these challenges [7, 8].…”

Section: Introductionmentioning

confidence: 99%

CD14 Promoter Polymorphisms in Atopic Families: Implications for Modulated Allergen-Specific Immunoglobulin E and G1 Responses

Jackola

Basu

Liebeler

et al. 2006

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: CD14 promoter DNA sequence polymorphisms for the endotoxin receptor gene have been implicated in modulating allergen-specific immunoglobulin (Ig)E responses in randomly selected individuals with atopy. We sought to determine if a single nucleotide polymorphism in the CD14 promoter region is associated with atopy in atopic families, and to assess its influence on serum levels of CD14 and allergen-specific IgE and IgG1 responses. Methods: We screened 367 members of 91 Caucasian nuclear families with a history of asthma for pulmonary function by spirometry, including methacholine challenge to detect bronchial hyperreactivity, and atopy by serum total IgE and skin prick test to 14 allergens. The CD14 promoter single nucleotide polymorphism was analyzed in DNA isolated from peripheral blood mononuclear cells to identify C/C, C/T and T/T genotypes. Serum tests were done for soluble CD14 (sCD14) and dust mite-specific antibody (Der p 1-IgG1). Results: Serum sCD14 levels were not associated with clinical phenotypes (asthma, bronchial hyperreactivity or atopy). However, sCD14 levels were inversely related to both allergen-specific IgE and Der p 1-IgG1 production, but only among those with evidence of atopic sensitization. Linear regression analysis, accounting for random family effects, demonstrated a higher production of allergen-specific IgE or Der p 1-IgG1 associated with the T/T genotype and a lower level of specific IgE and IgG1 production associated with sCD14 levels. Conclusions: An element of the innate immune system (CD14) has profound effects upon modulating the acquired allergen-specific immunoglobulin responses among those with an inherited atopic predisposition.

show abstract

“…Patient no. 17 was known to be clinically allergic to grass pollen [15]. When tested against a grass pollen extract, IgEs from serum no.…”

Section: Resultsmentioning

confidence: 99%

“…Patient no. 17 was found to be allergic to Dactylis pollen [15]. His sensitivity to rapeseed pollen was not known as being not clinically tested.…”

Section: Cross-reactivity To Peptidic Determinantsmentioning

confidence: 99%