1985
DOI: 10.1001/archderm.121.10.1297
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Isotretinoin vs etretinate therapy in generalized pustular and chronic psoriasis

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Cited by 15 publications
(3 citation statements)
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“…Isotretinoin may be preferred to acitretin in women with von Zumbusch type GPP of child-bearing age given its short half-life, however it may be less efficacious than acitretin 112 . Response is typically seen within several days to weeks.…”
Section: Pustular Psoriasis and Clinical Variantsmentioning
confidence: 99%
“…Isotretinoin may be preferred to acitretin in women with von Zumbusch type GPP of child-bearing age given its short half-life, however it may be less efficacious than acitretin 112 . Response is typically seen within several days to weeks.…”
Section: Pustular Psoriasis and Clinical Variantsmentioning
confidence: 99%
“…Clinical experience, how ever, indicated that certain psoriatic forms (c.g. general ized pustular psoriasis) and various other keratinizing dermatoses responded in a similar fashion as to etretinate [13], Thus, the mouse tests slightly underestimated the clinical efficacy of isotretinoin.…”
Section: Discussionmentioning
confidence: 97%
“…In clinical trials, isotretinoin has been studied only in a limited number of psoriatic patients. This was basically due to its relative lack of activity in this condition when compared to etretinate; furthermore, although high doses (1.5-2.0 mg/kg) showed some good clinical results, they were associated with hypervitaminosis A effects [13]. Thus, the therapeutic index of 0.5 for mice is reflected in the psoriatic patient by the fact that the risk of adverse effects outweighs the bene ficial therapeutic activity [10][11][12][13][14].…”
Section: Isotretinoin 13-cis-retinoic Acid (Ro 4-3780)mentioning
confidence: 99%