2000
DOI: 10.1001/archderm.136.10.1231
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Isotretinoin Use and Risk of Depression, Psychotic Symptoms, Suicide, and Attempted Suicide

Abstract: Background: It has been suggested that there is a causal association between isotretinoin therapy and the risk of depression, psychotic symptoms, suicide, and attempted suicide.Objective: To further investigate the proposed association between isotretinoin therapy and the risk of depression, psychotic symptoms, suicide, and attempted suicide using a formal study design.

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Cited by 239 publications
(174 citation statements)
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“…They did not find that patients were more likely to receive an antidepressant after receiving isotretinoin. Jick and colleagues (Jick et al 2000) looked at 7,195 patients treated with isotretinoin and 13,700 oral antibiotic users with acne from the Saskatchewan Health Database and 340 isotretinoin and 676 antibiotic users from the United Kingdom General Practice Research Database. Prevalence of suicide, attempted suicide, and "neurotic and psychotic disorders" based on computer-recorded histories at 0.5 to 5 years before and more than 5 years after medication use were compared between the groups.…”
Section: Retrospective Analyses Of Databasesmentioning
confidence: 99%
“…They did not find that patients were more likely to receive an antidepressant after receiving isotretinoin. Jick and colleagues (Jick et al 2000) looked at 7,195 patients treated with isotretinoin and 13,700 oral antibiotic users with acne from the Saskatchewan Health Database and 340 isotretinoin and 676 antibiotic users from the United Kingdom General Practice Research Database. Prevalence of suicide, attempted suicide, and "neurotic and psychotic disorders" based on computer-recorded histories at 0.5 to 5 years before and more than 5 years after medication use were compared between the groups.…”
Section: Retrospective Analyses Of Databasesmentioning
confidence: 99%
“…Since the mid-1980s, reports in the literature suggest a relationship between 13-cis-RA use and the onset of psychological symptoms including depression, suicidal ideation, and psychosis (Hazen et al, 1983;Bigby and Stern, 1988;Scheinman et al, 1990;Byrne and Hnatko, 1995;Wysowski et al, 2001;Ng and Schweitzer, 2003;O'Connell et al, 2003;Barak et al, 2005). However, there are also studies suggesting that there is no evidence of such a link (Jick et al, 2000;Jacobs et al, 2001;Ferahbas et al, 2004;Chai et al, 2005). One recent study used positron emission tomography to examine brain function in patients with treatment-resistant acne (Bremner et al, 2005).…”
Section: Introductionmentioning
confidence: 99%
“…It is surprising that 13-cis-RA might influence the adult brain, an organ in which there is not extensive proliferation. Certainly, this effect has been considered contentious (5), in large part because no mechanism has been described for such an etiology. Cell proliferation, however, is known to occur in restricted regions of the adult brain.…”
mentioning
confidence: 99%