Isotretinoin‐induced visual hallucinations in a patient with acne vulgaris

Saadet, Elif Demirci

doi:10.1111/pde.14807

Cited by 3 publications

(1 citation statement)

References 6 publications

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“… 36 Some investigators have reported the greatest reduction in both psychological and skin disease was achieved with oral isotretinoin therapy. 36 Isotretinoin has been linked to depression, suicide, psychosis and mania, 36 , 46 but a recent population-based study found no increased risk of psychiatric disorders associated with this drug. 47 As isotretinoin can reduce expression of MMPs, the reduction in depressive symptoms in acne patients may be explained in part through this anti-inflammatory effect.…”

Section: Resultsmentioning

confidence: 99%

The Mind Body Connection in Dermatologic Conditions: A Literature Review

Mar,

Rivers

2023

J Cutan Med Surg

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Psychodermatology pertains to the relationship between the skin and brain. This review aims to summarize the evidence of the mind body connection in four psychophysiological conditions: rosacea, atopic dermatitis (AD), acne vulgaris (AV), and psoriasis. A literature search was conducted using several English language databases. All four conditions share similar psychiatric co-morbidities, including but not limited to anxiety, depression, and suicidality. In rosacea, the upregulation of transient receptor potential vanilloid type 1, Toll like receptor 2, and Th17 cells releases downstream products that are simultaneously implicated in mood disorders. Stress exacerbates AV through the hypothalamic-pituitary-adrenal (HPA) system, which alters functioning of sebocytes and Cutibacterium acnes. In AD and psoriasis, the HPA axis influences Th1, Th2, Th22, and Th1, Th17 immune mediated responses, respectively. This leads to the secretion of pro-inflammatory cytokines which are also involved in the pathogenesis of anxiety and depression. Neurotransmitters implicated in mental illness, such as gamma-aminobutyric acid and serotonin, may also play a role in the development of AD and psoriasis. The management of cutaneous disease may mitigate psychological distress, and future research may show the corollary to also be true.

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