Isotretinoin and Adverse Psychiatric Effects

Magin, Parker; Prentice, Shaun

doi:10.1001/jamadermatol.2023.4577

Cited by 1 publication

(1 citation statement)

References 18 publications

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“…Isotretinoin can be associated with a variety of side effects, including photosensitivity, dry eyes, dry skin and mucosa, and bone and muscle symptoms. In particular, there have been debates and concerns about whether or not isotretinoin is related to psychiatric illness, including depression and suicide [10][11][12]. A systematic review and metaanalysis showed that there is no significant difference in depression rates between the users of isotretinoin and those on other treatment options [13].…”

Section: Introductionmentioning

confidence: 99%

Prescribing Patterns of Isotretinoin for Acne Among Dermatologists in Central Jordan

Al-Sheyab,

Alshiyab,

Al-Shagarin

et al. 2024

Cureus

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Introduction: Prescribing practices among dermatologists play a crucial role in managing acne, particularly concerning medications like isotretinoin. In Jordan's central region, encompassing the Governorates of Amman, Balqa, Zarqa, and Madaba, dermatologists in both public and private sectors encounter diverse cases of acne. Understanding their prescription patterns and awareness regarding isotretinoin usage is essential for optimizing acne treatment outcomes and minimizing potential risks. Methods: This study aimed to evaluate dermatologists' practices in prescribing isotretinoin for acne. It relied on the descriptive analytical approach, with the study population including all dermatologists working in the public and private sectors in the central region of Jordan. Simple random sampling was used to include 147 male and female doctors. An online questionnaire was adopted to collect data from the study sample, which was distributed through social media platforms and messaging platforms such as Facebook, WhatsApp, and Instagram to dermatologists working in the central region. Results: In this study of 147 dermatologists, 58 (39.45%) prescribed isotretinoin primarily for severe acne, and 53 (36.06%) prescribed isotretinoin to about 50-100 patients per year, with the initial dosage based on guidelines (n=102, 69.39%). The majority (n=115; 78.23%) refrained from prescribing if liver enzymes were elevated. Pregnancy tests were required by 42 (28.57%) in the first session, while 78 (53.07%) deemed it the patient's responsibility. Common precautions included sunscreen (n=77; 52.38%) and moisturizing cream (n=31, 21.09%). Only six of the dermatologists (4.08%) advised their patients not to use contact lenses, and only 17 (11.57%) prescribed moisturizing eye drops. Conclusion: This study's findings emphasize how crucial physicians' experience is when it comes to prescribing isotretinoin for severe acne. Continued educational initiatives are imperative to address gaps in patient information and safeguards in order to optimize treatment outcomes and ensure patient safety.

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