Isotopic Response

Wolf, Ronni; Brenner, Sarah; Ruocco, Vincenzo; Filioli, F. Grimaldi

doi:10.1111/j.1365-4362.1995.tb03616.x

Cited by 241 publications

(111 citation statements)

References 63 publications

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“…The term was coined in 1995 by Ronni Wolf, who described several types of cutaneous lesions occurring within the areas of cleared herpes zoster (majority) or, less frequently, herpes simplex [13,14,15]. The phenomenon does not seem to be rare, but has been overlooked or underreported.…”

Section: Lines Of Blaschkomentioning

confidence: 99%

“…Besides these skin patterns, several dermatological phenomena have been described in the literature as responses to various insults showing peculiar skin arrangement: the isotopic response of Wolf, the isomorphic Koebner phenomenon, their inverse variants (the reverse isotopic response or non-response and Renbok phenomenon), and the photo recall phenomenon [10,11,12,13,14,15]. These are not diseases, but define a reaction pattern of a secondary skin disease developing within a variable period of time (days, months, years, decades) after the initial insult.…”

Section: Lines Of Blaschkomentioning

confidence: 99%

“…Cutaneous areas that have been infected by herpes viruses (mainly varicella zoster virus) are known to be privileged sites for either selectively harbouring skin diseases (malignancies, infections, immune dysregulation) not appearing elsewhere (locus minoris resistentiae, lmr) or selectively rejecting skin diseases involving the rest of the body (locus majoris resistentiae, LMR) [11,12,13,14,15,17] (Fig. 4).…”

Section: Lines Of Blaschkomentioning

confidence: 99%

“…Skin areas that have been subjected to any kind of trauma (radiation dermatitis, stasis ulcers, chemical or thermal burns, vaccination site, tattoos, and amputation stumps) are fertile ground for the development of malignancy [12,13,18,19] (Fig. 5).…”

Section: Lines Of Blaschkomentioning

confidence: 99%

“…Locally hampered lymphatic drainage seen in chronic lymphedema as well as postoperative or posttraumatic lymph stasis may also hinder the normal trafficking of immunocompetent cells and act as cofactors in the Wolf phenomenon [12,13,14]. …”

Section: Lines Of Blaschkomentioning

confidence: 99%

See 4 more Smart Citations

The Puzzle of the Skin Patterns

Tenea¹

2016

Integr Med Int

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Background: The pattern of distribution of skin diseases remains one of the most elusive problems in dermatology, particularly when multiple pathologies are involved and coexistence of patterns is present. Most skin diseases show a predilection for certain body areas and are located in characteristic patterns. Many dermatoses exhibit lesions in a segmental fashion concomitantly with disseminated patterns. Sometimes the sites of predilection are inexplicable. Objectives: The main purpose of this paper is to give an overview on the peculiar arrangement of cutaneous lesions in both congenital and acquired skin disorders as well as reactive phenomena in vulnerable areas, in order to better recognise them clinically and understand their pathogenesis. Methods: Based on personal observations and a review of literature, this paper summarises the basics in understanding the patterned distribution of skin lesions, highlights the significance of the lines of Blaschko and their relationship with mosaicism, and describes some of the reactive skin phenomena. Results: Skin mosaicism plays a crucial role in the distribution and arrangement of skin lesions, as demonstrated by recent advances in genetic research in an increasing number of various skin diseases.

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Section: Lines Of Blaschkomentioning

confidence: 99%

Section: Lines Of Blaschkomentioning

confidence: 99%

Section: Lines Of Blaschkomentioning

confidence: 99%

Section: Lines Of Blaschkomentioning

confidence: 99%

Section: Lines Of Blaschkomentioning

confidence: 99%

See 3 more Smart Citations

The Puzzle of the Skin Patterns

Tenea¹

2016

Integr Med Int

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An Elderly Woman With Violaceous Swelling With Telangiectasia and Necrosis on the Face

Jia

Jin

2019

JAMA Dermatol

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Mechanical and Thermal Injury

Kennedy¹,

Burd²

2004

Rook's Textbook of Dermatology

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The skin is constantly subjected to both internal and external mechanical forces, so that for experimental purposes it may be impossible to determine what constitutes the normal resting state. These forces are likely to be as important in the maintenance of the structural integrity of the connective tissues of the skin [1,2] as they are with bone, which becomes demineralized during the protracted absence of normal gravitational force during space travel [3]. In contrast to events in the whole organism, isolated human dermal fibroblasts in culture make more collagen when subjected to reduced gravity [4]. Many normal biochemical functions of the skin are dependent on appropri-ate mechanical forces, and when these become excessive, as in lymphoedema, protease inhibitors are released with many deleterious consequences [5].Healthy skin is well adapted to resist the adverse effects of a wide range of mechanical injuries [6]. These include friction, pressure, contusion, laceration, suction and vibration. The clinical consequence of injury will depend on characteristics of the noxious stimulus, such as its intensity and duration. Factors related to the skin also influence the response; thus, the same degree of friction may produce a blister in one person but no visible change in another. Time is required for adaptive responses, such as callus formation and lichenification, to occur.

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Isotopic Response

Cited by 241 publications

References 63 publications

The Puzzle of the Skin Patterns

The Puzzle of the Skin Patterns

An Elderly Woman With Violaceous Swelling With Telangiectasia and Necrosis on the Face

Mechanical and Thermal Injury

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