Isotope Ratio Analysis of Lead in Blood and Environmental Samples by Multi-collector Inductively Coupled Plasma Mass Spectrometry

Takagi, M.; Yoshinaga, Jun; Tanaka, Atsushi; Seyama, Haruhiko

doi:10.2116/analsci.27.29

Cited by 23 publications

(20 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The ingestion rates assumed in the studies may also be the cause of this difference. Takagi et al [62] recently applied high-precision stable isotope analysis to source apportionment of lead in children's blood. They preliminarily presented a case study involving two children: one child had blood lead Fig.…”

Section: Lead In Other Materialsmentioning

confidence: 99%

“…6 Comparison of average lead concentration in food products belonging to 15 categories from European countries. Data source: European Food Safety Authority [53] isotope ratios close to those of house dust of the child's household, while approximately 50 % of blood lead in the other child was from house dust/soil [62]. If lead in house dust significantly contributes to the daily lead exposure of Japanese children, as indicated by Aung et al [41] and Takagi et al [62], some children, who live in homes with house dust with a higher lead concentration may be at risk of excessive exposure.…”

Section: Lead In Other Materialsmentioning

confidence: 99%

See 1 more Smart Citation

Lead in the Japanese living environment

Yoshinaga

2012

Environ Health Prev Med

Self Cite

View full text Add to dashboard Cite

Lead has long been known to be a neurotoxic heavy metal, particularly in the context of occupational health. However, its adverse effect on the cognitive development of children at lower exposure levels has only recently received attention. Although the exposure level of contemporary Japanese children is among the lowest in the world, it is desirable to reduce exposure as much as reasonably possible due to the absence of a threshold of exposure for adverse effects. In this review, information on lead levels in milieus of our proximate environment, such as the atmosphere, drinking water, soil, house dust, diet and others, of contemporary Japan was compiled with the aim of updating our knowledge on lead distribution. Monitoring data demonstrates that lead concentrations in the atmosphere and lead intake from food consumption have decreased substantially from the 1970s. Lead was hardly detectable in tap water in a recent nation-wide monitoring survey. To the contrary, elevated lead concentrations were detected in surface soil and house dust in one of the studies on daily exposure to lead from all potential sources, and both of these sources were regarded by the authors as significant contributors of lead exposure to general Japanese children. A similar study indicated that diet is the sole major source of lead for Japanese children. A significant difference was present in the estimated dietary lead intake levels in different studies, resulting in significant discrepancies in the current knowledge on lead in our environment. Further studies are warranted to identify the major source(s) of lead exposure in Japanese children in order to establish an effective countermeasure to reduce lead exposure to children.

show abstract

Section: Lead In Other Materialsmentioning

confidence: 99%

Section: Lead In Other Materialsmentioning

confidence: 99%

Lead in the Japanese living environment

Yoshinaga

2012

Environ Health Prev Med

Self Cite

View full text Add to dashboard Cite

show abstract

“…A sensitive analytical method for the measurement of PbIRs in blood and environmental samples has been developed using multi-collector ICP mass spectrometry [ 30 ]. This method was employed to identify proximate sources of Pb.…”

Section: Introductionmentioning

confidence: 99%

Source Identification Analysis of Lead in the Blood of Japanese Children by Stable Isotope Analysis

Takagi

Tanaka

Seyama

et al. 2020

IJERPH

Self Cite

View full text Add to dashboard Cite

Considering the negative effect of lead (Pb) on children’s neurodevelopment, Pb exposure should be minimized to the lowest extent possible, though the blood Pb (BPb) concentrations in Japanese children are among the lowest in the world. To identify the sources of Pb in blood, isotope ratios (IRs: 207Pb/206Pb and 208Pb/206Pb) of Pb (PbIR) in whole blood from eight Japanese children were measured by multi-collector ICP mass spectrometry. Further, samples of house dust, soil, duplicate diet, and tobacco, collected from home environments, were also measured and were compared with PbIR of blood case by case. The relative contribution of Pb in the home environment to BPb were estimated by linear programming (finding an optimal solution which satisfy the combination of IRs and intakes from various sources) when appropriate. Source apportionment for three children could be estimated, and contributions of diet, soil, and house dust were 19–34%, 0–55%, and 20–76%, respectively. PbIR for the remaining five children also suggested that non-dietary sources also contributed to Pb exposure, though quantitative contributions could not be estimated. Non-dietary sources such as soil, house dust, and passive tobacco smoke are also important contributors to Pb exposure for Japanese children based on PbIR results.

show abstract

“…533 Methods for Pb isotope ratio measurements in blood using MC ICP-MS have, however, also been published. 534,535 Another toxic element often investigated in a biomedical context is mercury. Humans are exposed to mercury from inhalation of elemental Hg 0 (e.g.…”

Section: Applications In Life Sciencesmentioning

confidence: 99%

Inductively Coupled Plasma Mass Spectrometry

Jakubowski

Horsky

Roos

et al. 2014

Sector Field Mass Spectrometry for Elemental and Isotopic Analysis

View full text Add to dashboard Cite

ICP-MS is based on the formation of (preferentially monovalent positively) charged atomic ions in an inductively coupled Ar plasma at almost 10 000 K. The ions formed are transferred from the plasma source at ambient pressure into a mass separator operated at high vacuum via a set of cones. The ions are separated according to their mass/charge ratio in the mass separator (quadrupole, magnetic sector field or time-of-flight mass separator). In most cases, the ions are detected using a secondary electron multiplier; in some set-ups (also) a Faraday cup can be used. Single-collector (scanning mass spectrometer usually used for quantitative elemental analysis) or multicollector (static operation of mass spectrometer for precise isotope ratio analysis) configurations can be found (Figures 12.1 and 12.2).

show abstract

Isotope Ratio Analysis of Lead in Blood and Environmental Samples by Multi-collector Inductively Coupled Plasma Mass Spectrometry

Cited by 23 publications

References 26 publications

Lead in the Japanese living environment

Lead in the Japanese living environment

Source Identification Analysis of Lead in the Blood of Japanese Children by Stable Isotope Analysis

Inductively Coupled Plasma Mass Spectrometry

Contact Info

Product

Resources

About