Isotope effects in the decarboxylation of 1-14C-dicarboxylic acids studied by means of the Schmidt reaction

Schmidt Reaction with Aldehydes and Carboxylic Acids

“…The same conclusion was reached by Rabinowitz et al 81 , who found an approximately 15% decrease in reaction velocity when the carbonyl carbon-12 atom in carboxylic acids was replaced by carbon-14. This is supported by the absence of a kinetic isotope effect for the reaction of benzoic acids 70 in D2O-D2SO4 relative to the H2O-H2SO4 system of the same composition (79.3%): kQ.…”