Isotope dilution mass spectrometry of microelectronically relevant heavy metal traces in high-purity cobalt

Beer, Bernhard; Heumann, Klaus G.

doi:10.1007/bf00323819

Cited by 19 publications

(4 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Whole blood samples were mineralised in a HNO 3 -H 2 O 2 mixture, using microwave digestion. Fe was separated from the matrix by anion-exchange chromatography following a solvent/solvent extraction step into diethyl ether (Beer & Heumann, 1993;Kastenmayer et al 1994). All isotopic analyses were performed by negative thermal ionisation -MS according to Walczyk (1997) using a magnetic sector field mass spectrometer (MAT 262; Finnigan MAT) equipped with a multi-collector system for simultaneous ion beam detection.…”

Section: Analysis Of Isotopic Composition Of Blood Samplesmentioning

confidence: 99%

The effect of retinyl palmitate added to iron-fortified maize porridge on erythrocyte incorporation of iron in African children with vitamin A deficiency

et al. 2003

View full text Add to dashboard Cite

Retinyl palmitate added to Fe-fortified maize bread has been reported to enhance Fe absorption in adult Venezuelan subjects but not in Western Europeans. It is not known to what extent these results were influenced by differences in vitamin A status of the study subjects. The objective of the present study was to evaluate the influence of retinyl palmitate added to Fe-fortified maize porridge on erythrocyte incorporation of Fe in children with vitamin A deficiency, before and after vitamin A supplementation. Erythrocyte incorporation of Festable isotopes was measured 14 d after intake of maize porridge (2·0 mg Fe added as ferrous sulfate) with and without added retinyl palmitate (3·5 mmol; 3300 IU). The study was repeated 3 weeks after vitamin A supplementation (intake of a single dose of 210 mmol retinyl palmitate; 'vitamin A capsule'). Vitamin A status was evaluated by the modified relative dose -response (MRDR) technique. Retinyl palmitate added to the test meal reduced the geometric mean erythrocyte incorporation of Fe at baseline from 4·0 to 2·6 % (P¼0·008, n 13; paired t test). At 3 weeks after vitamin A supplementation, geometric mean erythrocyte incorporation was 1·9 and 2·3 % respectively from the test meal with and without added retinyl palmitate (P¼0·283). Mean dehydroretinol:retinol molar ratios were 0·156 and 0·125 before and after intake of the single dose of 210 mmol retinyl palmitate; 'vitamin A capsule' (P¼0·15). In conclusion, retinyl palmitate added to the labelled test meals significantly decreased erythrocyte incorporation of Fe in children with vitamin A deficiency at baseline but had no statistically significant effect 3 weeks after vitamin A supplementation. The difference in response to retinyl palmitate added to Fe-fortified maize porridge on erythrocyte incorporation of Fe before and after intake of the vitamin A capsule indicates, indirectly, changes in vitamin A status not measurable by the MRDR technique. The lack of conclusive data on the effect of retinyl palmitate on Fe absorption indicates the complexity of the interactions between vitamin A status, dietary vitamin A and Fe metabolism.

show abstract

Section: Analysis Of Isotopic Composition Of Blood Samplesmentioning

confidence: 99%

The effect of retinyl palmitate added to iron-fortified maize porridge on erythrocyte incorporation of iron in African children with vitamin A deficiency

et al. 2003

View full text Add to dashboard Cite

show abstract

“…Each isotopically enriched blood sample was analyzed in duplicate under chemical blank monitoring. Whole blood samples were digested by microwave digestion with a nitric acid-hydrogen peroxide mixture, followed by separation of the sample iron from the matrix by anion-exchange chromatography and a subsequent solvent-solvent extraction step into diethylether (17,19,20). All isotopic analyses were performed by negative thermal ionization mass spectrometry with a magnetic sector field mass spectrometer (Finnigan MAT 262) equipped with a multicollector system for simultaneous ion beam detection (21).…”

Section: Analysis Of the Isotopic Composition Of The Blood Samplesmentioning

confidence: 99%

Iron bioavailability from iron-fortified Guatemalan meals based on corn tortillas and black bean paste

Davidsson

Dimitriou

Boy

et al. 2002

The American Journal of Clinical Nutrition

View full text Add to dashboard Cite

The bioavailability of iron from ferrous fumarate was not improved by the addition of Na(2)EDTA, contrary to what was previously shown for ferrous sulfate in other cereal-based meals. However, the bioavailability of iron from the test meal was significantly enhanced when NaFeEDTA replaced ferrous sulfate. These results support the use of NaFeEDTA in the fortification of inhibitory staple foods such as corn masa flour.

show abstract

“…Whole-blood samples were mineralised using an HNO 3 ±H 2 O 2 mixture (5 : 2, v/v) and microwave digestion. Sample Fe was separated from the matrix by anion-exchange chromatography following a solvent± solvent extraction step into diethyl ether (Beer & Heumann, 1993;Kastenmayer et al 1994;Walczyk et al 1997). All isotopic analyses were performed using a magnetic-sectorfield MS (MAT 262; Finnigan MAT) equipped with a multi-collector system for simultaneous ion-beam detection.…”

Section: Iron Isotopic Analysis Of Blood Samplesmentioning

confidence: 99%

Iron absorption from experimental infant formulas based on pea (Pisum sativum)-protein isolate: the effect of phytic acid and ascorbic acid

et al. 2001

View full text Add to dashboard Cite

Infant formula based on pea (Pisum sativum)-protein isolate has been suggested as an alternative to soyabean formula in countries where soyabean is not a native crop, or when soyabean protein cannot be used due to allergic reactions or intolerances. In the present study, Fe absorption from experimental infant formulas based on pea-protein isolate was measured in healthy non-anaemic young women. The influence of phytic acid and ascorbic acid on Fe absorption was evaluated, using a stable-isotope technique based on incorporation of Fe stable-isotope labels into erythrocytes 14 d after administration. Geometric mean Fe absorption increased from 20·7 (+1SD 41·6, -1sd 10·3) % to 33·1 (+1sd 58·6, -1sd 18·7) %; (P<0·0001; n 10) after enzymic degradation of virtually all phytic acid. Doubling the molar ratio Fe : ascorbic acid from 1 : 2·1 to 1 : 4·2 in the infant formula with native phytic acid content also increased Fe absorption significantly (P<0·0001; n 10); geometric mean Fe absorption increased from 14·8 (+1sd 32·1, -1sd 6·8) % to 22·1 (+1sd 47·2, -1sd 10·4) %. These results confirm the inhibitory and enhancing effects of phytic acid and ascorbic acid respectively on Fe absorption, but also indicate relatively high fractional Fe absorption from the pea-protein-based formulas. After adjusting for differences in Fe status, our data indicate that Fe absorption from dephytinised pea protein might be less inhibitory than dephytinised soyabean protein as measured in a previous study ().

show abstract

Isotope dilution mass spectrometry of microelectronically relevant heavy metal traces in high-purity cobalt

Cited by 19 publications

References 29 publications

The effect of retinyl palmitate added to iron-fortified maize porridge on erythrocyte incorporation of iron in African children with vitamin A deficiency

The effect of retinyl palmitate added to iron-fortified maize porridge on erythrocyte incorporation of iron in African children with vitamin A deficiency

Iron bioavailability from iron-fortified Guatemalan meals based on corn tortillas and black bean paste

Iron absorption from experimental infant formulas based on pea (Pisum sativum)-protein isolate: the effect of phytic acid and ascorbic acid

Contact Info

Product

Resources

About