Isothiazolinones: Sensitizers Not to Miss in Children

Quenan, Sandrine; Piletta, Pierre; Calza, Anne‐Marie

doi:10.1111/pde.12560

Cited by 11 publications

(11 citation statements)

References 16 publications

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“…Notwithstanding, the incidence of allergic contact dermatitis has increased because the concentration of MI required to achieve adequate biocidal activity is greater than the combination of MCI/MI. 7 Research finds that the individuals most at risk are women older than 40 years with facial eczema who use cosmetics. 3 Moreover, in those sensitized, most products used were either leave-on products or wet wipes as opposed to rinse-off products like shampoos.…”

Section: Discussionmentioning

confidence: 99%

Lichenoid contact dermatitis secondary to methylisothiazolinone (MI)

2016

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Section: Discussionmentioning

confidence: 99%

Lichenoid contact dermatitis secondary to methylisothiazolinone (MI)

2016

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“…test) , Chang and Nakrani reported six children (four girls, two boys, ages 3–8 years) with ACD to MI‐containing wet wipes using an epicutaneous patch test, and Admani et al published a case report of perianal dermatitis in a 9‐year‐old boy caused by contact allergy to MI‐containing wet wipes using an epicutaneous patch test. Quenen et al , in Geneva, Switzerland, recently reported four pediatric cases of MI contact allergy and stated that “it remains underdiagnosed in the United States because it is still tested in combination with MCI”. Thus the true prevalence of MCI/MI and specifically MI sensitization in children is unknown.…”

Section: Published Pediatric Patch Test Results To Methylchloroisothimentioning

confidence: 99%

“…Not testing MI alone has been reported to potentially miss 33% to 60% of patients sensitive to MI . Furthermore, Quenan et al noted that “[p]ractitioners widely use the [epicutaneous patch test] but it contains only the combination MCI/MI. This should raise awareness of the fact that MI should also be tested as a separate entity”.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, Quenan et al noted that “[p]ractitioners widely use the [epicutaneous patch test] but it contains only the combination MCI/MI. This should raise awareness of the fact that MI should also be tested as a separate entity”. This is also our observation; in a recent report, PCDR providers who were Society of Pediatric Dermatology members were more likely to use an epicutaneous patch test than comprehensive standard testing (odds ratio = 175, p < 0.001) (unpublished data).…”

Section: Discussionmentioning

confidence: 99%

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Appropriate Testing of Isothiazolinones in Children

Goldenberg

Lipp

Jacob

2017

Pediatric Dermatology

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“…4,5 The most common sources of exposure are wet wipes, cosmetics, and cleansing products. 6 Slime is a non-Newtonian liquid that has gained popularity among children because of its easily malleable structure. In addition to commercially available forms, there are numerous written or visual online recipes for the preparation of homemade slime.…”

Section: Discussionmentioning

confidence: 99%

“Slime”: A trending cause of isothiazolinone contact allergy in children

2019

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K E Y W O R D S : case report, contact allergy, methylchloroisothiazolinone/methylisothiazolinone, methylisothiazolinone, paediatric, slime dermatitis Methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI) (eg, Kathon CG), and MI are widely available preservatives that are mainly used in cosmetic and household products. Following a worldwide increase in contact allergy to MCI/MI and MI, 1 regulatory measures have been implemented. Although a decrease in contact sensitization has been reported, MCI/MI and MI are still frequent causes of contact dermatitis, and unexpected sources of exposure may be encountered in clinical practice. 2 Herein, we report three children with allergic contact dermatitis caused by MCI/MI and/or MI following exposure to a homemade play material called "slime." CASE REPORTSA 9-year-old girl presented with hand dermatitis of 3 months' duration. Dermatological examination showed papules and vesicles involving the lateral aspects of the fingers and periunguium ( Figure 1A). She had no personal or family history of atopy. Previous treatment attempts with topical corticosteroids led to temporary improvement, but the lesions had recurred. A 12-year-old girl was referred to our clinic with hand dermatitis of 5 months' duration. Physical examination showed erythematous, scaly plaques on both palms ( Figure 2A).The patient's medical history was insignificant. Treatment with topical corticosteroids was of no benefit. A 10-year-old, otherwise healthy girl presented with hand eczema that had developed after contact with homemade slime. Physical examination showed mild erythema with desquamation on the sides of the fingers ( Figure 3A). The patient claimed that the initial vesicular eruption has resolved shortly after she had stopped coming into contact with slime.The patients were patch tested with the European baseline series by the use of IQ Ultra Chambers obtained from Chemotechnique Diagnostics (Vellinge, Sweden). Reading of test results was performed on day (D) 2 and D3, according to ESCD guidelines. 3 The patch test results were as follows: In case 1, there was a + reaction to MCI/MI 0.02% aq. on D2, and there was a ++ reaction to MCI/MI 0.02% aq. on D3 ( Figure 1B). In case 2, there were + reactions to MCI/MI 0.02% aq. and to MI 0.2% aq. on D2, and ++ reactions to MCI/MI 0.02% aq. and to MI 0.2% aq. on D3 ( Figure 2B). In case 3, there was a ?+ reaction to MCI/MI 0.02% aq. on D2, and there was a + reaction to MCI/MI 0.02% aq. on D3 ( Figure 3B).A detailed repeat history showed contact with a homemade play material called "slime" in all three patients before the onset of symptoms.The cosmetic and household products added to the slime mixture were brought in by each patient, and detailed inspection of the labels and material safety data sheets confirmed the presence of MCI and MI in the following products: case 1-dishwashing liquid ( Figure S1A); case 2-Polyvinyl acetate glue (Figure S1B); and case 3-liquid soap ( Figure S1C). DISCUSSIONAlthough MCI/MI contact sensitization and MI contact s...

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Isothiazolinones: Sensitizers Not to Miss in Children

Cited by 11 publications

References 16 publications

Lichenoid contact dermatitis secondary to methylisothiazolinone (MI)

Lichenoid contact dermatitis secondary to methylisothiazolinone (MI)

Appropriate Testing of Isothiazolinones in Children

“Slime”: A trending cause of isothiazolinone contact allergy in children

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