Isothiazoles

Concise Approach to Benzisothiazol-3(2H)-one via Copper-Catalyzed Tandem Reaction of o-Bromobenzamide and Potassium Thiocyanate in Water

“…Then different N -substituted o -bromobenzamide derivatives were applied under the optimized conditions. The behaviors of benzisothiazol-3(2 H )-ones in fungistatic, antimicrobial, and antipsychotic bioactivities could be improved through the use of various N -substituents, , and our current work provides an easy-access procedure for the N -substituted benzisothiazol-3(2 H )-ones. It is noteworthy that in this case a higher temperature (160 °C) was required to complete the reaction.…”

“…Benzisothiazol-3(2 H )-ones are widely used as pharmaceutical agents because of their fungistatic, antimicrobial, and antipsychotic activities . Recently, benzisothiazol-3(2 H )-one derivatives were discovered to be a potentially antithrombotic agent that could be developed into a drug for the first-phase aggregation ex vivo in man .…”

Metal-assisted reactions. Part 29. Structure and hydrogenolysis of C–N bonds in derivatives of aromatic amines. Bond length and electronegativity changes from X-ray crystallographic data

“…Assignments in the benzisothiazole ring system were as given in ref. 22, except for positions 6, 7 which were deduced as shown in the note presented as ref. 21.…”

5,5′-Thiobis(3-bromoisothiazole-4-carbonitrile)

“…The synthesis of this highly Isothiazoles are five-membered heterocycles that have found uses as agrochemicals [14], pharmaceuticals [15] and dyes [16]. Their applications, chemistry and synthesis have been reviewed [17][18][19]. Examples of biologically useful isothiazoles are the fungicide isotianil (Stout ® ) [20,21], active against rice blast, and the antibacterial drug sulfasomizole [22,23].…”