Isothermal phase transformations of bovine-derived hydroxyapatite/bioactive glass: A study by design of experiments

Rincón-López, July Andrea; Hermann-Muñoz, Jennifer Andrea; Fernández-Benavides, David Andrés; Giraldo-Betancur, Astrid L.; Alvarado-Orozco, J.M.; Muñoz-Saldaña, J.

doi:10.1016/j.jeurceramsoc.2018.11.021

Cited by 12 publications

(35 citation statements)

References 39 publications

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“…The surface of assintered SC ceramics is shown in Fig. 1a, where the typical combination of faint microstructure with cracks and pores, is observed 16 . Micrographs with higher magnification are shown in Fig.…”

Section: Morphological and Chemical Analysismentioning

confidence: 99%

“…12. The spectrum of HAp has been incorporated for comparative purposes, in which the main vibrational modes of the HAp phase were identified; the PO 3 4group at a wavenumber around 440 cm -1 (ν2 symmetric bending mode), 600 cm -1 (ν4 antisymmetric bending mode), 967 cm -1 (ν1 symmetric stretching mode) and 1070 cm -1 (ν3 antisymmetric stretching mode) 13,16,32 . For the SC phase before the immersion, the most intense band around the 953 cm −1 showed the combined contribution of phosphate and silicate: the symmetric stretching mode of silicate and the ν1 mode of the phosphate group.…”

Section: Raman Spectroscopymentioning

confidence: 99%

“…An apatite growth formation mechanism from SC has been established by Serena et al 32 16 . Based on this, after immersion in Hank´s solution, the formation of apatite-like structures, C-S-H, and C-S-P-H hydrogels, due to SC hydration, will be expected.…”

Section: Mechanisms Of Apatite Formation and First Stages Of Maturation From Scmentioning

confidence: 99%

“…One of the phases of this complex ternary system is the Ca 5-x (PO 4 ) 2+x (SiO 4 ) 1-x ; x ≤ 0.3 phase, also known as silicocarnotite (SC), which crystallizes in an orthorhombic structure, with a P nma space group and lattice parameters a = 6.737 Å, b = 15.5080 Å, and c = 10.132 Å exhibiting a wide range of solid solution with CaO, SiO 2 and P 2 O 5 [12][13][14][15][16] .…”

Section: Introductionmentioning

confidence: 99%

“…for Na + or Mg 2+ , and Si 4+ for P 5+ due first to the non-stoichiometric Ca 3 (PO ) -rich SC phase produced from a solid solution 16 and second, the crystallization of C-S-P-H hydrogel into SC nanocrystal with average size of a about 70 nm.…”

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confidence: 99%

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Apatite Mineralization Process from Silicocarnotite Bioceramics: Mechanism of Crystal Growth and Maturation

Rincón-López

Hermann-Muñoz

Cinca-Luis

et al. 2020

Crystal Growth & Design

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A mechanism for the formation and crystallization processes of bone-like apatite grown on non-stoichiometric silicocarnotite (SC) is here proposed. Single-phase SC powders and ceramics were obtained from fixed mixtures of hydroxyapatite and bioactive glass 45S5. The bioactive behavior of SC was assessed by immersion in Hank´s solution at different times.Afterward, a systematic theoretical-experimental study of the structural properties at the micro and nanoscale using TEM was performed and correlated with SEM, EDX, XRD, and Raman techniques to determine the apatite mineralization process from the SC phase. The initial stage of apatite formation from SC was identified as the hydration and further polymerization of silanol groups, resulting in a silica-based hydrogel, which plays a critical role in the ionic exchange. As a result of the adsorption of ionic species from the medium into the silica-based hydrogel, the precipitation of crystalline apatitic structures starts through the emergence of newly formed SC nanocrystals, which act as a template for the crystallization process of a substituted apatite with SC-like structure. Then, due to the polymorphism between SC and HAp structures, the apatite layer retains the SC periodic arrangement following an epitaxial-like growth mechanism. Identification of the apatite layer formation mechanism is critical to understand its physical and chemical properties, which controls the long-term dissolution/precipitation rate of bioactive materials and their performance in the biological environment.

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Section: Morphological and Chemical Analysismentioning

confidence: 99%

Section: Raman Spectroscopymentioning

confidence: 99%

Section: Mechanisms Of Apatite Formation and First Stages Of Maturation From Scmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Apatite Mineralization Process from Silicocarnotite Bioceramics: Mechanism of Crystal Growth and Maturation

Rincón-López

Hermann-Muñoz

Cinca-Luis

et al. 2020

Crystal Growth & Design

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Mineral matrix deposition of MC3T3‐E1 pre‐osteoblastic cells exposed to silicocarnotite and nagelschmidtite bioceramics: In vitro comparison to hydroxyapatite

Rincón‐López,

Hermann‐Muñoz,

Detsch

et al. 2024

J Biomedical Materials Res

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This work presents the effect of the silicocarnotite (SC) and nagelschmidtite (Nagel) phases on in vitro osteogenesis. The known hydroxyapatite of biological origin (BHAp) was used as a standard of osteoconductive characteristics. The evaluation was carried out in conventional and osteogenic media for comparative purposes to assess the osteogenic ability of the bioceramics. First, the effect of the material on cell viability at 24 h, 7 and 14 days of incubation was evaluated. In addition, cell morphology and attachment on dense bioceramic surfaces were observed by fluorescence microscopy. Specifically, alkaline phosphatase (ALP) activity was evaluated as an osteogenic marker of the early stages of bone cell differentiation. Mineralized extracellular matrix was observed by calcium phosphate deposits and extracellular vesicle formation. Furthermore, cell phenotype determination was confirmed by scanning electron microscope. The results provided relevant information on the cell attachment, proliferation, and osteogenic differentiation processes after 7 and 14 days of incubation. Finally, it was demonstrated that SC and Nagel phases promote cell proliferation and differentiation, while the Nagel phase exhibited a superior osteoconductive behavior and could promote MC3T3‐E1 cell differentiation to a higher extent than SC and BHAp, which was reflected in a higher number of deposits in a shorter period for both conventional and osteogenic media.

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The effect of alpha-lithium aluminate incorporation on the properties of bovine bone-derived hydroxyapatite

Pazarlıoğlu

2022

J Aust Ceram Soc

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Isothermal phase transformations of bovine-derived hydroxyapatite/bioactive glass: A study by design of experiments

Cited by 12 publications

References 39 publications

Apatite Mineralization Process from Silicocarnotite Bioceramics: Mechanism of Crystal Growth and Maturation

Apatite Mineralization Process from Silicocarnotite Bioceramics: Mechanism of Crystal Growth and Maturation

Mineral matrix deposition of MC3T3‐E1 pre‐osteoblastic cells exposed to silicocarnotite and nagelschmidtite bioceramics: In vitro comparison to hydroxyapatite

The effect of alpha-lithium aluminate incorporation on the properties of bovine bone-derived hydroxyapatite

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