Isotachophoretic determination of stability constants of Ho and Y complexes with diethylenetriaminepentaacetic acid and 1,4,7,10-tetraazadodecane-N,N′,N″,N‴-tetraacetic acid

Koudelková, Michaela; Vinšová, Hana; Jedináková-Křížová, V.

doi:10.1016/s0021-9673(02)01703-x

Cited by 15 publications

(8 citation statements)

References 12 publications

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“…These observations follow more or less the trends expected from the stability constants, log K , for the formation of [M II (DOTA)] 2− and [M III (DOTA)] − complexes: Bi 3+ = 30.3 16 > Sc 3+ = 27.0 72 > Y 3+ = 24.4 71 > Zn 2+ = 18.7 61 > Ca 2+ = 16.4 61 > Mg 2+ = 11.2. 61 These have been measured using UV-Visible spectrophotometry, 16,76,77 HPLC chromatography 72 or isotachophoresis 71 in aqueous solutions. The conspicuous absence of stability constants for the antimony complex in the literature is due to the rapid hydrolysis of Sb 3+ and Sb 5+ ions in aqueous solutions.…”

Section: Resultssupporting

confidence: 79%

“…S2 and S3 † ). Stability constants of 30.3, 16 24.4 71 and 27.0 72 have been reported for [Bi(DOTA)] − , [Y(DOTA)(H 2 O)] − and [Sc(DOTA)] − , respectively. High in vivo stability, of this order of magnitude, is a prerequisite for using chelated isotopes in diagnostic medical imaging and therapy.…”

Section: Resultsmentioning

confidence: 98%

“…In competition experiments, aqueous solutions of Na[Sb(DOTA)]$4H 2 O (1 mM) were mixed with one or two equivalents of M 2+ (Ca, Mg and Zn) and M 3+ (Sc, Y and Bi) ions (1 mM). The mass spectra of these solutions shows that Sb 61 These have been measured using UV-Visible spectrophotometry, 16,76,77 HPLC chromatography 72 or isotachophoresis 71 in aqueous solutions. The conspicuous absence of stability constants for the antimony complex in the literature is due to the rapid hydrolysis of Sb 3+ and Sb 5+ ions in aqueous solutions.…”

Section: Competitive Metal Bindingmentioning

confidence: 99%

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Facile transmetallation of [Sb^III(DOTA)]⁻ renders it unsuitable for medical applications

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Section: Resultssupporting

confidence: 79%

Section: Resultsmentioning

confidence: 98%

Section: Competitive Metal Bindingmentioning

confidence: 99%

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Facile transmetallation of [Sb^III(DOTA)]⁻ renders it unsuitable for medical applications

et al. 2022

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“…ITP was used for the determination of the stability constants of anionic holmium and yttrium complexes with diethylenetriaminepentaacetic acid and 1,4,7,10-tetraazadodecane-N,N',N",N"'-tetraacetic acid [17,18]. The method is based on a linear relation between the stability constant and the reduction of the zone of the complex owing to the loss of free metal ions.…”

Section: Methodsmentioning

confidence: 99%

Recent progress in capillary ITP

2007

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ITP has been attracting constant attention for many years due to its principal capability to concentrate trace analytes by several orders of magnitude. In the current capillary format, it is able to concentrate trace analytes diluted to several microliters of an original sample into concentrated zones having volumes in the range of picoliters. Due to this reason, ITP holds an important position in many current multistage and multidimensional separation schemes. This article links up previous reviews on the topic and summarizes the progress of analytical capillary ITP since 2002. Almost 100 papers are reviewed that include methodological novelties, instrumental aspects, and analytical applications. Papers using ITP and/or isotachophoretic principles as part of multistage and/or multidimensional separation schemes are also included.

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“…A comparison of the thermodynamic stability constant of H 4 octapa to other ligands with Y 3+ shows the log a Calculated for 10 μM total ligand and 1 μM total [M 3+ ] at pH 7.4 and 25 °C. b pM values for DTPA and DOTA with Y 3+ were calculated for this work, based upon previously determined log K ML , 49 ligand pK a , 50,51 and metal ion pK a values. 52 K ML value to be similar to DTPA, but lower than the current "gold standard" DOTA (Table 1).…”

Section: Thermodynamic Stabilitymentioning

confidence: 99%

Modular syntheses of H₄octapa and H₂dedpa, and yttrium coordination chemistry relevant to⁸⁶Y/⁹⁰Y radiopharmaceuticals

et al. 2014

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The ligands H2dedpa, H4octapa, p-SCN-Bn-H2dedpa, and p-SCN-Bn-H4octapa were synthesized using a new protection chemistry approach, with labile tert-butyl esters replacing the previously used methyl esters as protecting groups for picolinic acid moieties. Additionally, the ligands H2dedpa and p-SCN-Bn-H2dedpa were synthesized using nosyl protection chemistry for the first time. The use of tert-butyl esters allows for deprotection at room temperature in trifluoroacetic acid (TFA), which compares favorably to the harsh conditions of refluxing HCl (6 M) or LiOH that were previously required for methyl ester cleavage. H4octapa has recently been shown to be a very promising (111)In and (177)Lu ligand for radiopharmaceutical applications; therefore, coordination chemistry studies with Y(3+) are described to assess its potential for use with (86)Y/(90)Y. The solution chemistry of H4octapa with Y(3+) is shown to be suitable via solution NMR studies of the [Y(octapa)](-) complex and density functional theory (DFT) calculations of the predicted structure, suggesting properties similar to those of the analogous In(3+) and Lu(3+) complexes. The molecular electrostatic potential (MEP) was mapped onto the molecular surface of the DFT-calculated coordination structures, suggesting very similar and even charge distributions between both the Lu(3+) and Y(3+) complexes of octapa(4-), and coordinate structures between 8 (ligand only) and 9 (ligand and one H2O). Potentiometric titrations determined H4octapa to have a formation constant (log K(ML)) with Y(3+) of 18.3 ± 0.1, revealing high thermodynamic stability. This preliminary work suggests that H4octapa may be a competent ligand for future (86)Y/(90)Y radiopharmaceutical applications.

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Isotachophoretic determination of stability constants of Ho and Y complexes with diethylenetriaminepentaacetic acid and 1,4,7,10-tetraazadodecane-N,N′,N″,N‴-tetraacetic acid

Cited by 15 publications

References 12 publications

Facile transmetallation of [Sb^III(DOTA)]⁻ renders it unsuitable for medical applications

Facile transmetallation of [Sb^III(DOTA)]⁻ renders it unsuitable for medical applications

Recent progress in capillary ITP

Modular syntheses of H₄octapa and H₂dedpa, and yttrium coordination chemistry relevant to⁸⁶Y/⁹⁰Y radiopharmaceuticals

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Isotachophoretic determination of stability constants of Ho and Y complexes with diethylenetriaminepentaacetic acid and 1,4,7,10-tetraazadodecane-N,N′,N″,N‴-tetraacetic acid

Cited by 15 publications

References 12 publications

Facile transmetallation of [SbIII(DOTA)]− renders it unsuitable for medical applications

Facile transmetallation of [SbIII(DOTA)]− renders it unsuitable for medical applications

Recent progress in capillary ITP

Modular syntheses of H4octapa and H2dedpa, and yttrium coordination chemistry relevant to86Y/90Y radiopharmaceuticals

Contact Info

Product

Resources

About

Facile transmetallation of [Sb^III(DOTA)]⁻ renders it unsuitable for medical applications

Facile transmetallation of [Sb^III(DOTA)]⁻ renders it unsuitable for medical applications

Modular syntheses of H₄octapa and H₂dedpa, and yttrium coordination chemistry relevant to⁸⁶Y/⁹⁰Y radiopharmaceuticals