Isosteviol sodium attenuates high fat/high cholesterol-induced myocardial dysfunction by regulating the Sirt1/AMPK pathway

Mei, Ying; Hu, Hui; Deng, Liangjun; Sun, Xiaoou; Tan, Wen

doi:10.1016/j.bbrc.2022.06.044

Biochemical and Biophysical Research Communications

2022

DOI: 10.1016/j.bbrc.2022.06.044

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Isosteviol sodium attenuates high fat/high cholesterol-induced myocardial dysfunction by regulating the Sirt1/AMPK pathway

Ying Mei

Hui Hu

Liangjun Deng

et al.

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Cited by 3 publications

References 37 publications

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Targeting mitochondrial shape: at the heart of cardioprotection

Hernandez-Resendiz,

Prakash,

Loo

et al. 2023

Basic Res Cardiol

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There remains an unmet need to identify novel therapeutic strategies capable of protecting the myocardium against the detrimental effects of acute ischemia–reperfusion injury (IRI), to reduce myocardial infarct (MI) size and prevent the onset of heart failure (HF) following acute myocardial infarction (AMI). In this regard, perturbations in mitochondrial morphology with an imbalance in mitochondrial fusion and fission can disrupt mitochondrial metabolism, calcium homeostasis, and reactive oxygen species production, factors which are all known to be critical determinants of cardiomyocyte death following acute myocardial IRI. As such, therapeutic approaches directed at preserving the morphology and functionality of mitochondria may provide an important strategy for cardioprotection. In this article, we provide an overview of the alterations in mitochondrial morphology which occur in response to acute myocardial IRI, and highlight the emerging therapeutic strategies for targeting mitochondrial shape to preserve mitochondrial function which have the future therapeutic potential to improve health outcomes in patients presenting with AMI.

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Targeting mitochondrial shape: at the heart of cardioprotection

Hernandez-Resendiz,

Prakash,

Loo

et al. 2023

Basic Res Cardiol

View full text Add to dashboard Cite

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Attenuation of Cardiomyocyte Hypertrophy Via Inhalation of Isosteviol-Loaded Exosome in Mice

Guo,

Li,

et al. 2024

Pharm Chem J

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The potential of herbal drugs to treat heart failure: The roles of Sirt1/AMPK

Zhang,

Xu,

Guo

et al. 2024

Journal of Pharmaceutical Analysis

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Isosteviol sodium attenuates high fat/high cholesterol-induced myocardial dysfunction by regulating the Sirt1/AMPK pathway

Cited by 3 publications

References 37 publications

Targeting mitochondrial shape: at the heart of cardioprotection

Targeting mitochondrial shape: at the heart of cardioprotection

Attenuation of Cardiomyocyte Hypertrophy Via Inhalation of Isosteviol-Loaded Exosome in Mice

The potential of herbal drugs to treat heart failure: The roles of Sirt1/AMPK

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