Isospora cholangiopathy: case study with histologic characterization and molecular confirmation

Walther, Zenta; Topazian, Mark D.

doi:10.1016/j.humpath.2009.01.020

Cited by 42 publications

(33 citation statements)

References 13 publications

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“…Bile duct infection may be seen, while disseminated disease is probably rare but has been reported for AIDS patients. Recurrences are common, and the chronic nature of the illness contributes to morbidity and mortality among these patients (204)(205)(206). Sulfamethoxazole-trimethoprim treatment provides a good clinical response and is the drug of choice (207).…”

Section: Cystoisosporamentioning

confidence: 99%

Molecular Testing for Clinical Diagnosis and Epidemiological Investigations of Intestinal Parasitic Infections

2014

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SUMMARY Over the past few decades, nucleic acid-based methods have been developed for the diagnosis of intestinal parasitic infections. Advantages of nucleic acid-based methods are numerous; typically, these include increased sensitivity and specificity and simpler standardization of diagnostic procedures. DNA samples can also be stored and used for genetic characterization and molecular typing, providing a valuable tool for surveys and surveillance studies. A variety of technologies have been applied, and some specific and general pitfalls and limitations have been identified. This review provides an overview of the multitude of methods that have been reported for the detection of intestinal parasites and offers some guidance in applying these methods in the clinical laboratory and in epidemiological studies.

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Section: Cystoisosporamentioning

confidence: 99%

Molecular Testing for Clinical Diagnosis and Epidemiological Investigations of Intestinal Parasitic Infections

2014

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“…Human acalculous cholecystitis due to C. belli infection was first reported in 1994 from a 39-year-old homosexual man with HIV, and histopathological investigation of the gallbladder specimens stained with hematoxylin and eosin stain revealed chronic inflammation along with stages of development with distinctive feature of C. belli in the thickened wall [16]. Diffuse biliary cystoisosporiasis has been also reported in a West African man who presented with acute illness and dilated bile ducts, and unknown HIV status [17]. The first case of Sarcocystis-related human non-calculous cholecystitis worldwide was reported in 2014 in an AIDS patient [4].…”

Section: Discussionmentioning

confidence: 98%

Cystoisosporiasis-related human acalculous cholecystitis: the need for increased awareness

Agholi¹,

Aliabadi²,

Hatam³

2016

pjp

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Cholecystitis is one of the common surgical indications affecting human beings in many countries. A variety of infectious agents can be associated with acute or chronic acalculous cholecystitis, especially in HIV/AIDS patients. In this investigation, the authors aim to describe two cases of histologically and molecularly documented cystoisosporiasis (syn. isosporiasis) as the cause of chronic acalculous cholecystitis in two immunodeficient patients. During microscopic examinations of more than 2500 diarrheic patients' samples, 11 cases of cystoisosporiasis-related recurrent persistent/chronic diarrhea were detected. A review of the medical records of Cystoisospora belli (syn. Isospora belli)-positive patients showed that two of them, i.e. a patient with prolonged corticosteroid therapy and an AIDS patient, several months prior to fecal examinations had undergone cholecystectomy due to acalculous cholecystitis. The study was continued by a review of the histopathological investigation of the recuts prepared from the excised gallbladder tissue sections and stained with hematoxylin and eosin in order to detect a possible specific clinical correlation with cystoisosporiasis. Light microscopic examination revealed the presence of various developmental stages of a coccidial parasite, namely Cystoisospora belli, in both patients' gallbladder tissue sections. To the best of our knowledge, C. belli-associated cholecystitis has not been previously reported in a patient with prolonged corticosteroid therapy.

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“…These organisms include Cytomegalovirus, Microsporidium, Cryptosporidium, Isospora belli, and Cyclospora cayetanensis species (Pitlik et al 1983, Chui and Owen 1994, Reiter 1995, Knapp et al 1996, Zar et al 2001, Walther and Topazian 2009. Extra intestinal cystlike stages of coccidian parasites have been documented in patients with AIDS, and may play a role in relapse from the infection.…”

Section: Discussionmentioning

confidence: 99%

“…Unfortunately, cholecystitis is increasingly being recognized as a complication of AIDS (Chui andOwen 1994, Vakil et al 1996). The parasitic opportunistic agents that have been most commonly associated with this disorder are Cryptosporidium, Isospora and Cyclospora ( Benator et al 1994, Ackers 1997, Zar et al 2001, Walther and Topazian 2009.…”

Section: Introductionmentioning

confidence: 99%

First detection of acalculous cholecystitis associated with Sarcocystis infection in a patient with AIDS

Agholi

Heidarian

Moghadami

et al. 2014

Acta Parasitologica

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Acalculous cholecystitis and cholangitis are increasingly being recognized as complications of AIDS. The opportunistic parasites that have been most commonly associated with these disorders are Cryptosporidium species, Isospora belli, Cyclospora cayetanensis and Enterocytozoon bieneusi. The authors performed a parasitological survey on the gallbladder tissue sections of patients underwent cholecystectomy due to chronic acalculous cholecystitis at the Shiraz University of Medical Sciences, Iran. Light microscopic investigation in more than three hundred archived histopathological slides revealed the presence of sexual stages (i.e., mature sporocysts) of a coccidial protozoan in a patient with AIDS who developed acalculous cholecystitis as confirmed by histological, parasitological and molecular tests in which Sarcocystis species was the only identifiable pathogen in gallbladder sections. In the best of our knowledge it's the first documented case of chronic non-calculous cholecystitis due to Sarcocystis parasite in an Iranian AIDS patient from worldwide.

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Isospora cholangiopathy: case study with histologic characterization and molecular confirmation

Cited by 42 publications

References 13 publications

Molecular Testing for Clinical Diagnosis and Epidemiological Investigations of Intestinal Parasitic Infections

Molecular Testing for Clinical Diagnosis and Epidemiological Investigations of Intestinal Parasitic Infections

Cystoisosporiasis-related human acalculous cholecystitis: the need for increased awareness

First detection of acalculous cholecystitis associated with Sarcocystis infection in a patient with AIDS

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