Isosorbide dinitrate for the relief of severe heart failure after myocardial infarction

Mantle, John A.; Russell, Richard O.; Moraski, Roger E.; Rackley, Charles E.

doi:10.1016/0002-9149(76)90322-2

Cited by 83 publications

(24 citation statements)

References 21 publications

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“…Reduction of afterload on the left ventricle by vasodilator therapy has been shown to be effective in the treatment of congestive heart failure [2,4,5], Although sodium nitroprusside and phentolamine produce a beneficial effect in patients with heart failure, these drugs cannot be used for long-term therapy because they have to be given intravenously [2,7].…”

mentioning

confidence: 99%

Use of Nitroglycerin Ointment in Congestive Heart Failure

Chandraratna¹,

Langevin²,

Odell³

et al. 1978

Cardiology

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7 consecutive patients with congestive heart failure refractory to standard therapy were treated with nitroglycerin ointment (GTNO). The pulmonary wedge pressure decreased from a control value of 30 ± 1 to 15 ± 1 mm Hg (mean ± SEM), and the arteriovenous oxygen difference narrowed from 6.8 ± 0.5 to 5.5 ± 0.3 ml%, after GTNO therapy. The heart rate decreased in 5 patients and the systolic blood pressure was either unchanged or decreased slightly. A reduction in the echocardiographic end diastolic dimension was noted in all patients. The transmyocardial gradient (systemic artery diastolic pressure – pulmonary artery wedge pressure) increased in all except 1 subject. The double product decreased in 5 of the 7 patients. Hemodynamic improvement was maintained for 4.5–7 h. All patients were symptomatically improved on chronic GTNO treatment. Our results indicate that GTNO is a useful agent in the management of heart failure which is unresponsive to standard therapy.

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mentioning

confidence: 99%

Use of Nitroglycerin Ointment in Congestive Heart Failure

Chandraratna¹,

Langevin²,

Odell³

et al. 1978

Cardiology

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“…Mean systemic arterial pressure (BP) and mean coronary sinus pressure (C5P) were obtained by (Bouchard, Gault & Ross, 1971;Mantle, Russell, Moraski & Rackley, 1976;Bussman, Lohner & Kaltenbach, 1977).…”

Section: Calculationsmentioning

confidence: 99%

Comparative peripheral and coronary haemodynamic effects of rimiterol and isoprenaline.

Stephens¹,

Hayward²,

Ead³

et al. 1978

Brit J Clinical Pharma

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I Rimiterol and isoprenaline produced significant dose-related increases in cardiac output. 2 These changes in cardiac output were accompanied by increases in heart rate and myocardial oxygen consumption which were similar for each drug and dose-related. 3 Isoprenaline in contrast with rimiterol produced direct coronary vasodilation, i.e. coronary vasodilation in excess of that required to meet increases in myocardial oxygen demands.4 It is suggested that the P-adrenergic receptors in the human coronary vasculature are mainly of the /5, type.

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“…Nitroglycerine eased angina or paroxysmal nocturnal dyspnea. 8,9 Patients typically died of profound organ failure or sudden cardiac death. Perhaps most distressing were patients with myocardial infarction who had suffered the consequences of abrupt, severe myocardial failure.…”

mentioning

confidence: 99%

The Heart Failure Paradox: An Epidemic of Scientific Success

Jessup

2014

Circulation

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Isosorbide dinitrate for the relief of severe heart failure after myocardial infarction

Cited by 83 publications

References 21 publications

Use of Nitroglycerin Ointment in Congestive Heart Failure

Use of Nitroglycerin Ointment in Congestive Heart Failure

Comparative peripheral and coronary haemodynamic effects of rimiterol and isoprenaline.

The Heart Failure Paradox: An Epidemic of Scientific Success

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