Isorhamnetin-3-glucoside alleviates oxidative stress and opacification in selenite cataract in vitro

Devi, V. Gayathri; Rooban, B.N.; Sasikala, V.; Sahasranamam, V.; Abraham, Annie

doi:10.1016/j.tiv.2010.05.021

Cited by 42 publications

(15 citation statements)

References 31 publications

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“…One pharmacological study supports the use of C. religiosum as a treatment for eye afflictions. Devi et al [111] discovered that a bioactive flavonoid (IR3G) isolated from the leaves of C. religiosum protected enucleated rat lenses from sodium selenite-induced cataract formation in vitro. These pharmacological studies provide substantial evidence that many of the traditional medicines from Cochlospermum species are effective and may even be more effective than modern treatments due to the rise of parasite and bacterial resistance [112,113].…”

Section: Resultsmentioning

confidence: 99%

Comparing Medicinal Uses of Cochlospermaceae throughout Its Geographic Range with Insights from Molecular Phylogenetics

Johnson-Fulton

Watson

2018

Diversity

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Species of the Cochlospermaceae, a small mostly pantropical plant family, were evaluated at a continental scale for medicinal uses in traditional medicine. This ethnobotanical information was placed in a phylogenetic framework to make informed predictions in the search for new medicines and bioactive compounds. Medicinal plant-use data were mapped onto a molecular phylogeny based on DNA sequences of nuclear and chloroplast markers. Associations of medicinal uses among closely related species occurring in different geographic regions and among diverse cultures were evaluated. The most common medicinal uses for these species are those used to treat skin ailments, gastro-intestinal problems, malaria, and liver issues. The plant species with the most numerous uses is Cochlospermum tinctorium, which occurs primarily in West Africa. Closely related species being used by cultural groups in different geographic regions to treat the same illnesses suggests the presence of bioactive compounds with potential biomedical value, since they may represent independent discoveries of similar medicinally-active compounds. This leads to the speculation that those closely related species not currently being used to treat these ailments may also contain identical or similar medicinally-active compounds and are worthy of laboratory investigations.

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Section: Resultsmentioning

confidence: 99%

Comparing Medicinal Uses of Cochlospermaceae throughout Its Geographic Range with Insights from Molecular Phylogenetics

Johnson-Fulton

Watson

2018

Diversity

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“…The glucoside of isorhamnetin (methylated quercetin), isolated as a bioactive flavonoid from the leaves of Cochlospermum religiosum (Gayathri et al ., 2010) and flavonoid fraction isolated from fresh leaves of Vitex negundo (Rooban et al ., 2011) protected enucleated rat eye lenses against selenite-induced cataract in an in vitro culture model.…”

Section: Anticataract Action Of Flavonoidsmentioning

confidence: 99%

Natural flavonoids as potential multifunctional agents in prevention of diabetic cataract

Štefek¹

2011

Interdisciplinary Toxicology

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Cataract is one of the earliest secondary complications of diabetes mellitus. The lens is a closed system with limited capability to repair or regenerate itself. Current evidence supports the view that cataractogenesis is a multifactorial process. Mechanisms related to glucose toxicity, namely oxidative stress, processes of non-enzymatic glycation and enhanced polyol pathway significantly contribute to the development of eye lens opacity under conditions of diabetes. There is an urgent need for inexpensive, non-surgical approaches to the treatment of cataract. Recently, considerable attention has been devoted to the search for phytochemical therapeutics. Several pharmacological actions of natural flavonoids may operate in the prevention of cataract since flavonoids are capable of affecting multiple mechanisms or etiological factors responsible for the development of diabetic cataract. In the present paper, natural flavonoids are reviewed as potential agents that could reduce the risk of cataract formation via affecting multiple pathways pertinent to eye lens opacification. In addition, the bioavailability of flavonoids for the lens is considered.

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“…Three mechanisms involved in d -galactose-induced cataract have been proposed [ 21 ]. Oxidative stress is believed to play a pivotal role in cataract formation [ 22 , 23 , 24 ]. Several reports showed that oxidative damage contributed to d -galactose cataract development in immature and mature rats [ 25 , 26 , 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Selenoprotein R Protects Human Lens Epithelial Cells against D-Galactose-Induced Apoptosis by Regulating Oxidative Stress and Endoplasmic Reticulum Stress

Dai

Liu

Zhou

et al. 2016

IJMS

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Selenium is an essential micronutrient for humans. Much of selenium’s beneficial influence on health is attributed to its presence within 25 selenoproteins. Selenoprotein R (SelR), known as methionine sulfoxide reductase B1 (MsrB1), is a selenium-dependent enzyme that, like other Msrs, is required for lens cell viability. In order to investigate the roles of SelR in protecting human lens epithelial (hLE) cells against damage, the influences of SelR gene knockdown on d-galactose-induced apoptosis in hLE cells were studied. The results showed that both d-galactose and SelR gene knockdown by siRNA independently induced oxidative stress. When SelR-gene-silenced hLE cells were exposed to d-galactose, glucose-regulated protein 78 (GRP78) protein level was further increased, mitochondrial membrane potential was significantly decreased and accompanied by a release of mitochondrial cytochrome c. At the same time, the apoptosis cells percentage and the caspase-3 activity were visibly elevated in hLE cells. These results suggested that SelR might protect hLE cell mitochondria and mitigating apoptosis in hLE cells against oxidative stress and endoplasmic reticulum (ER) stress induced by d-galactose, implying that selenium as a micronutrient may play important roles in hLE cells.

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Isorhamnetin-3-glucoside alleviates oxidative stress and opacification in selenite cataract in vitro

Cited by 42 publications

References 31 publications

Comparing Medicinal Uses of Cochlospermaceae throughout Its Geographic Range with Insights from Molecular Phylogenetics

Comparing Medicinal Uses of Cochlospermaceae throughout Its Geographic Range with Insights from Molecular Phylogenetics

Natural flavonoids as potential multifunctional agents in prevention of diabetic cataract

Selenoprotein R Protects Human Lens Epithelial Cells against D-Galactose-Induced Apoptosis by Regulating Oxidative Stress and Endoplasmic Reticulum Stress

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