Isoquinoline Alkaloids from Whole Plants of Thalictrum cirrhosum and Their Antirotavirus Activity

An efficient synthesis of 6‐arylpyrazolo[4′,3′:4,5]pyrimido[2,1‐a] isoquinolin‐8(9H)‐one derivatives catalyzed by AgOTf

“…Isoquinoline is an important nitrogen heterocycle in pharmaceutical chemistry bearing antirotavirus, [ 1 ] antimelanogenic, [ 2 ] and antitumor [ 3 ] activities. Pyrimide and pyrazole are also nitrogenous heterocycles but bearing two nitrogen atoms.…”

Three New Quinoline Alkaloids from the Whole Plant of Thalictrum atriplex and Their Bioactivities

“…3,4 The previous studies on the chemical constituents have indicated that the plants of this genus are a rich resource of alkaloids, and most of which possess many kinds of biological activities. [4][5][6][7][8][9][10][11][12] Thalictrum atriplex commonly called 'Ma Wei Lian' or 'Shui Huang Lian', is a traditional herbal medicine, and mainly distributes in Tibet, Sichuan and Yunnan provinces, and this plant had been used for the treatment of infectious hepatitis, carbuncles, dysenteric diarrhea and certain gastroenteric disorders in China. 13 Modern medicinal chemistry investigations also revealed that alkaloids, triterpenoids, flavonoids and the like, are the main constituents of the plant.…”

“…In order to discover more bioactive components from Thalictrum species, we now investigated the chemical constituents of the whole plant of T. atriplex collected in Yulong County, Lijiang Prefecture, Yunnan Province. As a result, three new quinoline alkaloids, thalicalkaloids A-C (1-3), together with three known alkaloids (4)(5)(6) were isolated. This paper describes the elucidation of the structures of these compounds, and a preliminary evaluation of their antibacterial and anti-rotavirus activity.…”

“…and extracted with EtOAc again. The EtOAc-soluble alkaloidal materials were subjected repeatedly to column chromatography on silica gel and preparative HPLC to afford three new quinoline alkaloids, thalicalkaloid A (1), thalicalkaloid B (2), and thalicalkaloid C (3), together with three known alkaloids (4)(5)(6). The structures of compounds 1-6 were shown in Figure 1, and the 1 H and 13 C NMR data of 1-3 were listed in Table 1.…”