Isoquercitrin from Argemone platyceras inhibits carbachol and leukotriene D4-induced contraction in guinea-pig airways

Fernández, J. E.; Reyes, Ricárdo; Ponce, H.; Oropeza, Martha; VanCalsteren, Marie Rose; Jankowski, Christopher J.; Campos, Marı́a G.

doi:10.1016/j.ejphar.2005.08.046

Cited by 51 publications

(37 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, fl avonoids suppress the production of Th2-type cytokines by activated human basophils [43]. Quercetin and isoquercitrin have been shown to inhibit the bronchial obstruction induced by different stimuli in models of allergic asthma [17,18]. However, the anti-infl ammatory activity of quercetin and isoquercitrin has never been studied in a murine model of asthma.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma

et al. 2007

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…In a guinea pig model of asthma, quercetin prevented allergen-induced and platelet-activating factor-induced bronchial obstruction, as well as bronchial hyperreactivity [17]. Isoquercitrin also demonstrated anti-asthmatic activity by inhibiting of carbachol-and leukotriene D4-induced contraction in guinea pig airways [18].…”

Section: Introductionmentioning

confidence: 93%

Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma

et al. 2007

View full text Add to dashboard Cite

show abstract

“…However, there was no research being done to simultaneously determine the contents of rutin and isoquercitrin in HMF. It is known that rutin and isoquercitrin have significant pharmacological activities of anti-inflammatory, analgesic, antibacterial, anti-oxidation and antitumor (12,13). Moreover, rutin also has protective action on heart, brain and kidney injuries after ischemic reperfusion and gastric mucosa injury (12).…”

Section: Introductionmentioning

confidence: 99%

Determination of Rutin and Isoquercetin Contents in Hibisci mutabilis Folium in Different Collection Periods by HPLC

Liu

Mei

Wan

et al. 2015

Journal of Chromatographic Science

View full text Add to dashboard Cite

Hibisci mutabilis Folium (HMF), the dried leaf of Hibiscus mutabilis (Malvaceae), is commonly used in traditional Chinese medicine. This article aimed to establish a high-performance liquid chromatography method for the determination of rutin and isoquercitrin contents in the HMF, and to compare the content variation in all the samples, including nearly withered yellow leaf, in different collection periods, so as to provide research basis for the quality evaluation and determination of the optimal collection period. A reversed-phase HPLC separation method was employed, with a BDS Hypersil C 18 column (4.6 m × 250 mm, 5 μm), under the following conditions: acetonitrile-0.3% phosphoric acid (15:85, v/v) solution as the mobile phase, flow rate 1.0 mL/min at 30°C and detection wavelength 254 nm. The calibration curves for rutin and isoquercitrin were linear over the range of 1.5-48 and 0.25-8 μg/mL, and the average recoveries were 99.92 and 100.45% (RSD: 2.39% and 2.11%, respectively)]. Based on the analysis results, it was found that contents of rutin and isoquercitrin in HMF (mature green leaf ) harvested in different periods had significant difference, and reached the highest in mid-December. It was also found that the contents of the two components in the mature green leaf were much higher than those in the nearly withered leaf from the same collection period. In conclusion, the results indicated that the HPLC method was easy-to-operate and precise, and could be applied for the determination of rutin and isoquercitrin contents in the HMF. The experimental data also showed that early winter should be the most suitable collection period for HMF.

show abstract

“…Adicionalmente, a quercetina também inibe a desgranulação de neutrófi los, produção de ânions superóxido e modula a ativação de mastócitos (Min, et al, 2007;Das, et al, 2003;Xagorari et al, 2000;Harborne, 2000). O fl avonol glicosilado isoquercitrina (12), derivado de quercetina, mostrou atividade inibitória da resposta induzida por LTD 4 , modulador da contração da musculatura lisa e hiperreatividade brônquica e um dos promotores da resposta infl amatória na asma (Fernandez et al, 2005).…”

Section: Flavonóidesunclassified

Substâncias de origem vegetal potencialmente úteis na terapia da asma

Corrêa¹,

Melo²,

Costa³

2008

Rev. bras. farmacogn.

View full text Add to dashboard Cite

RESUMO:A asma é uma doença infl amatória crônica, que representa um problema de saúde pública com altos números de óbitos e elevado impacto socioeconômico. A patologia é caracterizada pela fase imediata, mediada pela resposta aguda de células infl amatórias, e a tardia, que é responsável pela resposta com envolvimento de células específi cas do sistema imunológico. Atualmente, os principais tipos de fármacos utilizados no tratamento da asma são os broncodilatadores e agentes antiinfl amatórios, que aliviam os sintomas de broncoespasmo e diminuem a infl amação das vias aéreas. Entretanto, terapias com esses medicamentos não são totalmente efi cazes e provocam efeitos adversos. A escassez de fármacos seguros e o baixo acesso da população carente aos tratamentos utilizados estimulam a busca de novas substâncias potencialmente úteis no tratamento da asma. Produtos naturais de origem vegetal representam um grande potencial farmacológico contra asma, uma vez que podem fornecer moléculas diversas com mecanismos específi cos para tratamento e controle da patologia. A busca por terapias mais efi cientes e específi cas para o processo asmático mostra que a procura nos produtos naturais é promissora e possui um papel importante para a descoberta de novas terapias contra a asma.Unitermos: Asma, infl amação crônica, células Th2, plantas medicinais, produtos naturais, metabólitos secundários.ABSTRACT: "Natural products from plant origin potentially usefull in the asthma therapy". Asthma is a chronic infl ammatory disease, which represents a huge public health problem in developed and developing countries, has high death rates and elevated socioeconomic implications. The pathology is characterized by two different phases: the initial stage, mediated by acute infl ammatory cell response and the late phase, responsible for specifi c immune cells. Currently, the main drugs used for asthma treatment are bronchodilator and anti-infl ammatory agents, which mechanisms focus the relief of symptoms and attenuation of airway infl ammation. However, therapies with those drugs have side effects besides they are not totally effective. Poor accessibility in the development countries and scarcity of safety drugs lead the search for new drugs to asthma treatment. Herbal natural products have elevated pharmacological potential against asthma, once they provide several molecules with specifi c mechanisms for the pathology control and treatment. Thus, search in herbal natural products plays an important role to fi nd out specifi c and effective mechanisms.

show abstract

Isoquercitrin from Argemone platyceras inhibits carbachol and leukotriene D4-induced contraction in guinea-pig airways

Cited by 51 publications

References 21 publications

Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma

Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma

Determination of Rutin and Isoquercetin Contents in Hibisci mutabilis Folium in Different Collection Periods by HPLC

Substâncias de origem vegetal potencialmente úteis na terapia da asma

Contact Info

Product

Resources

About