Isoproterenol-induced responses in the regional polyamine metabolism of the rat heart

Selmeci, L.; Bardócz, Susan; Egyed, Zsófia

doi:10.1016/0006-291x(82)91865-4

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1986

1992

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“…Isoprenaline causes a f-receptor-mediated induction of ODC activity, with subsequent polyamine accumulation in the heart [18,19]. We have found that N'l-acetylspermidine also greatly increases in response to the catecholamine.…”

Section: Discussionmentioning

confidence: 72%

Accumulation of N1-acetylspermidine in heart and spleen of isoprenaline-treated rats

Stefanelli¹,

Carati²,

Rossoni³

et al. 1986

Biochemical Journal

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N1-Acetylspermidine is not detectable in rat heart, but its content greatly increases after a single injection of isoprenaline (10 mg/kg), reaching a concentration of about 10 nmol/g of tissue 4 h after the treatment. Part of the accumulated N1-acetylspermidine was split to putrescine. Isoprenaline also caused an increase of N1-acetylspermidine in the spleen, where its concentration increased 3.5-fold 6 h after the catecholamine. The accumulation of N1-acetylspermidine was dependent on the dose of isoprenaline in both the heart and the spleen, and was strongly inhibited by beta-antagonists and inhibitors of protein synthesis.

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Section: Discussionmentioning

confidence: 72%