Our system is currently under heavy load due to increased usage. We're actively working on upgrades to improve performance. Thank you for your patience.
“…From one side the level of IsoPs informs us about the severity of neuronal damage caused by oxidative stress as the concentration was higher in the DCI group vs. non-DCI and control and from the other, their biological potential to affect the DNA synthesis in the smooth muscle cells, as well as mitogenesis and stimulation of platelets aggregation, broblast proliferation and vasoconstriction, all of which may also play a role in DCI pathophysiology [39]. In our work, we also showed that poor outcome and DCI occurrence were more frequently observed in older patients with the cut-off point at 60years, as it already had been suggested in the literature [42].…”
Background
Delayed cerebral ischemia (DCI) is a serious, life-threatening, complication affecting patients who have survived the initial bleeding from a ruptured intracranial aneurysm. Due to the challenging diagnosis, potential DCI prognostic markers should be of value in clinical practice. According to recent reports isoprostanes and red blood cell distribution (RDW) showed to be promising in this respect.
Methods
We conducted a prospective study with a control group (n=8), recruiting aSAH patients (n=27), who underwent surgery within the first day of the initial bleeding. We collected data regarding clinical status and results of biochemical, and radiological examinations. We measured cerebrospinal fluid (CSF) concentration of 8-iso-prostaglandin F2α (F2-IsoP) and RDW on day 1, 3, and 5.
Results
Both CSF F2-IsoP level and RDW measured on day 1 were significant predictors of DCI. The receiver operating characteristics curve for DCI prediction based on the multivariate model yielded an area under the curve (AUC) of 0.924 (95%CI: 0.824-0.1, p<0.01).
Conclusions
In our study, the model based on the combination of RDW and the level of isoprostanes in CSF on the first day after the initial bleeding showed a prognostic value for DCI prediction. Further studies are required to validate this observation.
“…From one side the level of IsoPs informs us about the severity of neuronal damage caused by oxidative stress as the concentration was higher in the DCI group vs. non-DCI and control and from the other, their biological potential to affect the DNA synthesis in the smooth muscle cells, as well as mitogenesis and stimulation of platelets aggregation, broblast proliferation and vasoconstriction, all of which may also play a role in DCI pathophysiology [39]. In our work, we also showed that poor outcome and DCI occurrence were more frequently observed in older patients with the cut-off point at 60years, as it already had been suggested in the literature [42].…”
Background
Delayed cerebral ischemia (DCI) is a serious, life-threatening, complication affecting patients who have survived the initial bleeding from a ruptured intracranial aneurysm. Due to the challenging diagnosis, potential DCI prognostic markers should be of value in clinical practice. According to recent reports isoprostanes and red blood cell distribution (RDW) showed to be promising in this respect.
Methods
We conducted a prospective study with a control group (n=8), recruiting aSAH patients (n=27), who underwent surgery within the first day of the initial bleeding. We collected data regarding clinical status and results of biochemical, and radiological examinations. We measured cerebrospinal fluid (CSF) concentration of 8-iso-prostaglandin F2α (F2-IsoP) and RDW on day 1, 3, and 5.
Results
Both CSF F2-IsoP level and RDW measured on day 1 were significant predictors of DCI. The receiver operating characteristics curve for DCI prediction based on the multivariate model yielded an area under the curve (AUC) of 0.924 (95%CI: 0.824-0.1, p<0.01).
Conclusions
In our study, the model based on the combination of RDW and the level of isoprostanes in CSF on the first day after the initial bleeding showed a prognostic value for DCI prediction. Further studies are required to validate this observation.
“…Initially, lipid metabolism was implicated in the growth and development of IA. Markers such as F2-isoprostanes and F4-neuroprostanes, indicators of oxidative stress, have been underscored as being instrumental in the progression of IA [90][91][92]. Concurrently, compelling evidence links total cholesterol (TC) and HDL levels as independent prognostic indicators of mortality and delayed cerebral ischemia in the aftermath of aSAH [93].…”
Section: Lipid Metabolism As a Biomarker And Therapeuticmentioning
Many vascular diseases are linked to lipid metabolism disorders, which cause lipid accumulation and peroxidation in the vascular wall. These processes lead to degenerative changes in the vessel, such as phenotypic transformation of smooth muscle cells and dysfunction and apoptosis of endothelial cells. In intracranial aneurysms, the coexistence of lipid plaques is often observed, indicating localized lipid metabolism disorders. These disorders may impair the function of the vascular wall or result from it. We summarize the literature on the relationship between lipid metabolism disorders and intracranial aneurysms below.
“…F2-Isoprostane (F2-IsoPs) is a unique series of prostaglandin-like compounds that are formed in vivo and in vitro through a non-enzymatic peroxidation mechanism mediated by free radicals of arachidonic acid ( Fig. 1 ) [ 3 , 8 ]. This compound was first discovered by Morrow and colleagues who explained the formation of F2-IsoPs from arachidonic acid [ 3 , [8] , [9] , [10] ].…”
Section: Introductionmentioning
confidence: 99%
“…1 ) [ 3 , 8 ]. This compound was first discovered by Morrow and colleagues who explained the formation of F2-IsoPs from arachidonic acid [ 3 , [8] , [9] , [10] ]. Fig.…”
Section: Introductionmentioning
confidence: 99%
“…Roberts and Marrow explained that there are six main advantages to using F2-IsoPs as a marker for oxidative damage in vivo [ 3 , 8 , 9 , 11 , 12 ].…”
Introduction
The central nervous system (CNS) is the most metabolically active organ characterized by high oxygen demand and relatively low anti-oxidative activity, which makes neurons and glia highly susceptible to damage by reactive oxygen and nitrogen byproducts as well as neurodegeneration. Free radicals are associated with secondary injuries that occur after a primary brain injury. Some of these free radical products include F2-Isoprostane (F2-IsoPs), malondialdehyde (MDA), 4-hydroxy-2-nonenal (4-HNE) and acrolein.
Methods
In this study we measured serum F2-IsoPs levels as markers of free radical activity in 10–12 week-old male Sprague-Dawley rats weighing 200–300 g, all rats (n = 10) subjected with a head injury according to the modified marmourou model, then divided into 2 groups, one group treated with CAPE (Caffeic Acid Phenethyl Ester) (n = 5) and the other not treated with CAPE (n = 5), serum levels in the two groups were compared starting from day-0 (before brain injury), day-4 and day-7.
Results
We found lower F2-IsoPs levels in the group that received the CAPE treatment compared to the group that did not receive the CAPE treatment.
Conclusion
CAPE is capable of significantly reducing oxidative stress in brain injury.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
