Isonitrile antibiotics, a new class of antibiotics with an isonitrile group. I. Fermentation, isolation and characterization of isonitrile antibiotics.

Fujiwara, Akiko; Okuda, Tôru; Masuda, Setsuko; Shiomi, Yoshihiko; Miyamoto, Chikara; Sekine, Yuzuru; Tazoe, Masaaki; Fujiwara, Mitsuhiko

doi:10.1271/bbb1961.46.1803

Cited by 21 publications

(4 citation statements)

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“…Dermadin (105) was also isolated from T. koningii in 1975 (Tamura et al 1975) and its methyl ester derivative (106) obtained from T. hamatum (Brewer et al 1979). All data available for 105 seems to fit with that reported for isonitrinic acid E, which was isolated from T. hamatum in 1982 (Fujiwara et al 1982). In this work isonitrinic acid F (107) was also described.…”

Section: Isocyano Metabolitessupporting

confidence: 61%

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Secondary metabolites from species of the biocontrol agent Trichoderma

et al. 2007

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Trichoderma species are free-living fungi that are highly interactive in root, soil and foliar environments and have been used successfully in field trials to control many crop pathogens. Structural and biological studies of the metabolites isolated from Trichoderma species are reviewed. This review, encompassing all the literature in this field up to the present and in which 269 references are cited, also includes a detailed study of the biological activity of the metabolites, especially the role of these metabolites in biological control mechanisms. Some aspects of the biosynthesis of these metabolites and related compounds are likewise discussed.

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Section: Isocyano Metabolitessupporting

confidence: 61%

“…X-ray crystallographic analyses were performed by Ollis et al (1980). Isonitrins A (113), B (114), C and D (115) were obtained from T. hamatum in 1982 (Fujiwara et al 1982). Data for isonitrin C appear to be identical to those corresponding to 112.…”

Section: Isocyano Metabolitesmentioning

confidence: 99%

Secondary metabolites from species of the biocontrol agent Trichoderma

et al. 2007

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“…Dermadin (Figs. 3-16') from T. viride [44,45], T. koningii [46] and T. hamatum [47] is an antibiotic metabolite that was patented in 1971 [48]. The isonitrile trichoviridin (Figs.…”

Section: Isocyano Metabolitesmentioning

confidence: 99%

“…The isonitrile trichoviridin (Figs. 3-18) isolated from T. koningii [46][47][48][49] and T. viride showed in vitro antibiotic properties [50]. Several dermadin and trichoviridin analogous have also been isolated.…”

Section: Isocyano Metabolitesmentioning

confidence: 99%

Trichoderma Secondary Metabolites Active on Plants and Fungal Pathogens

Vinale¹,

Sivasithamparam²,

Ghisalberti³

et al. 2014

TOMYCJ

230

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Beneficial microbes typically produce bioactive molecules that can affect the interactions of plants with their pathogens. Many secondary metabolites may also have antibiotic properties, which enable the producing microbe to inhibit and/or kill other microorganisms i.e. competing for a nutritional niche. Indeed, some of these compounds have been found to play an important role in the biocontrol of plant diseases by various beneficial microbes used worldwide for crop protection and bio-fertilization. In addition to direct toxic activity against plant pathogens, biocontrol-related metabolites may also increase disease resistance by triggering systemic plant defence activity, and/or enhance root and shoot growth. Fungi belonging to the Trichoderma genus are well known producers of secondary metabolites with a direct activity against phytopathogens and compounds that substantially affect the metabolism of the plant. The widescale application of selected metabolites to induce host resistance and/or to promote crop yield may become a reality in the near future and represents a powerful tool for the implementation of IPM strategies.

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A review of the volatile metabolites of fungi found on wood substrates

McAfee¹,

Taylor²

1999

Nat. Toxins

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The holdings of eight collections of fungi have been examined for organisms isolated from wood and/or trees. Further selection of these fungi has been made according to their reported ability to produce volatile, biologically active metabolites. It is emphasized that the isolates in the collections do not necessarily produce such metabolites. The list of fungi fulfilling these conditions is slightly augmented by reports we have found in the literature, where the fungi concerned have not yet been deposited. The biochemistry of these compounds is considered with particular emphasis on their biosynthesis including that by Homo sapiens. The physiological and toxicological activity of these metabolites is reviewed especially with reference to their potential role in the complex symbioses existent in, for example, a tree. The review concludes with a discussion of areas of botany deserving increased attention in the hope that this will stimulate further work. The statements in the review are based on 173 references.

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Isonitrile antibiotics, a new class of antibiotics with an isonitrile group. I. Fermentation, isolation and characterization of isonitrile antibiotics.

Cited by 21 publications

References 0 publications

Secondary metabolites from species of the biocontrol agent Trichoderma

Secondary metabolites from species of the biocontrol agent Trichoderma

Trichoderma Secondary Metabolites Active on Plants and Fungal Pathogens

A review of the volatile metabolites of fungi found on wood substrates

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