Isonicotinohydrazide conformation in a supramolecular system with 1,4-benzenedicarboxylic acid and Zn²⁺ and Mn²⁺

Abstract

2015) Isonicotinohydrazide conformation in a supramolecular system with 1,4-benzenedicarboxylic acid and Zn 2+ and MnAn anti-tuberculosis drug, isonicotinohydrazide (INH), is studied concerning its conformation in different crystalline environments. In the present work, compounds with zinc (1) and manganese (2) ions are reported where INH has different conformations, caused by hydrogen bonds with 1,4-benzenedicarboxylic acid (H 2 BDC) and water molecules and by coordination bonds involving its functional groups. In 1, INH is coordinated to two zinc ions, where H 2 BDC and crystallization water molecules form several hydrogen bonds giving rise to a complex three-dimensional (3-D) network. In 2, both INH and H 2 BDC molecules are coordinated to manganese as well as four water molecules. The complex formed interacts by hydrogen bonds forming a 2-D arrangement. A 3-D network extension arises from other hydrogen bonds generated by crystallization water. In these two compounds, the presence of BDC ion and water molecules is very important in the stabilization of the complexes and in INH conformation. This work is focused on the structural description of formed compounds.

Intercatenated Coordination Polymers (ICPs) of Carboxylato Bridged Zn(II)-Isoniazid and Their Electrical Conductivity

“…In this work, we have used alkane/alkene dicarboxylates as bridging ligands and isoniazid (iso­nicotinyl­hydra­zide, INH), a first line anti-mycobacterial drug, as another linker. Isoniazid and its derivatives have been used as linkers to constitute hybrid materials. − Three different dicarboxylates, succinic acid (saturated) (H 2 succ), fumaric acid (single CC bond) (H 2 fum), and terephthalic acid (aromatic dicarboxylic acid), have been used to synthesize bridging dicarboxylates of the {Zn­(isonia­zid) or Zn­(INH)} motif (Scheme ). The CPs reported in this work display a surprising effect on the conductivity at an applied potential across it, and [Zn­(INH)­(succ)] n shows the highest activity in the switching applications.…”

“…The asymmetric unit of 3 consists of a distorted octahedral Zn(II) center in a ZnN 2 O 4 coordination sphere (Figure 2(v, vi)), bridged by both the INH ligand and the bdc linker and constitutes a (4,4)-grid of dimensions 11.098 × 9.116 Å 2 (Figure 2(vi); Supporting Information, Figure S12). A report of a Zn(II)-coordination polymer 58 of INH with bdc shows no coordination of bdc to Zn(II), while it shows hydrogen bonded secondary interaction. Therefore, we may applaud that it is the first example of a coordination polymer of Zn(II) with INH and bdc ligands.…”