Isoniazid Microencapsulation With HPMCP HP-50 and HPMCP HP-55 (2:3) Coating Using Solvent Evaporation Method

Abstract

The combination formulation of tuberculosis drugs may cause interactions if drugs are given simultaneously. Rifampin (RIF) decomposes in the stomach when given concurrently with isoniazid (INH), which results in a decrease in the bioavailability of RIF. The purposed is to make INH microcapsules using HPMCP HP-50 and HP-55 coatings to prevent these interactions. The process of making INH: HPMCP HP-50 and HP-55 (2:3) microcapsules was done by using solvent evaporation method. The entrapment efficiency of INH: HPMCP HP-50 and HP-55 (2:3) were 83.21% and 91.57%, respectively. The dissolution test of INH: HPMCP HP-50 and HP-55 microcapsules met the requirements of the Indonesian Pharmacopoeia Edition V. The FTIR results showed that there was no change either in the chemical composition of isoniazid or in the coating of the microencapsulation. Scanning Electron Microscopy (SEM) showed the active substance was well coated. This study resulted in a novel formula for microcapsules INH:HPMCP HP-50 and HP-55 (2:3) which can prevent the decomposition of RIF when given together with INH with a delayed release effect so that INH will be released in the intestine.