Isoniazid induced childhood diabetes: A rare phenomenon

Abstract

Drugs raise blood glucose concentrations via two broad mechanisms: By reducing insulin biosynthesis or secretion, or by reducing tissue sensitivity to insulin. Until date, there have been very few reported cases of isoniazid induced diabetes. We are presenting a case report of 6-year-old child with isoniazid induced diabetes who was misdiagnosed initially as a case of type 1 diabetes mellitus. We hereby stress that before diagnosing a patient with diabetes-type 1 or 2, a detailed history of drug intake for any such drugs, which can cause hyperglycemia has to be taken. Clear cut knowledge/cognizance of all such culprit drugs is therefore required.

Prevalence of tuberculosis and diabetes comorbidity in patients attending secondary healthcare hospital in south India

“…The drug isoniazid is prone to induce diabetes by affecting the Krebs cycle and increasing the glucagon secretion. [ 13 ] The most commonly treated diseases at the community level include diabetes, hypertension, infections like TB, etc., Owing to high prevalence at the primary care level, it would be desirable and rationale for the primary care physicians to know the deleterious effects of one disease on other's pathogenesis and treatment. There is a high need to identify the prevalence and treat the patients presenting with both DM and TB and to focus on the morbidity imposed by one disease on the other.…”