Isoniazid-Associated Hepatitis in 114 Patients

The long-term follow-up after idiosyncratic drug-induced liver injury with jaundice

“…Chronic liver disease, including the development of cirrhosis, has been reported with a suspect causality to a number of different drugs [1][2][3][4][5][6][7][8][9][10][11]. Information concerning development of chronic evolution originates mostly from case reports or small case series, and chronic liver disease due to drug-induced liver injury (DILI) is considered rare.…”

Isoniazid Hepatotoxicity Associated With Treatment of Latent Tuberculosis Infection

“…For decades, it has been well documented that INH can cause adverse effects on the liver, ranging from mild transient elevations in aminotransferases (transaminases), which occur in approximately 10 to 20% of patients, to overt hepatitis, occurring much more rarely. [1][2][3][4][5][6][7][8][9][10]7,8,10 of INH hepatotoxicity have resulted in the identification of several risk factors, most importantly age Ͼ 35 years. Other risk factors include female gender and concurrent use of ethanol.…”

Research Challenges, New Drug Development, Preclinical and Clinical Trials in the Ageing Population

“…Perhaps the most useful illustrative example is that of isoniazid-induced elevation in transaminases, and hepatitis. In this instance, a toxic end-point which is well described but unusual in younger patients has much higher incidence (about 8-fold higher) in the elderly patient subset (Black et al 1973). Another example of a known drug toxicity which increases in incidence with advancing age is benzodiazepine-induced cognitive impairment, as noted previously; however, this may represent more an extension of a desired therapeutic effect compared with the case of isoniazid-induced hepatic dysfunction.…”