Isoniazid- and ethambutol-induced psychosis

Prasad, Rajendra; Garg, Rajiv; Verma, Sanjeev

doi:10.4103/1817-1737.43083

Cited by 37 publications

(31 citation statements)

References 4 publications

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“…Many anti-TB agents are known to be cause of psychiatric adverse events i.e. isoniazid [10], ciprofloxacin [11], ethambutol [10], ethionamide [12] and cycloserine [8,[13][14][15][16], in this case the culprit drug was cycloserine. Therefore, the administration of cycloserine was stopped.…”

Section: Discussionmentioning

confidence: 99%

Influence social and healthcare support on psychiatric adverse events in MDR-TB patient

Reviono

Harsini

Aphridasari

et al. 2018

J Infect Dev Ctries

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Introduction: Multidrug resistance tuberculosis (MDR-TB) is a continuing threat because the treatment is rather toxic. One of the causes of poor treatment outcome is due to the adverse events, especially the occurrence of psychiatric adverse events. Methodology: The two cases presented in this paper are MDR-TB patients with psychiatric adverse events related to depression spectrum. The diagnosis of psychiatric adverse events was done by psychiatrist in the referral hospital. Results: The treatment of MDR-TB and psychiatric adverse event was carried out simultaneously. One of the patients was able to manage the adverse events, but the other was not. The management of psychiatric adverse events need to be performed carefully. Social support of family and friends was received by the successful patient, while the other was not fully supported, thus failed the treatment. Conclusion: The social support provided by the family and friends are precious for the successful treatment of MDR-TB psychiatric adverse events. The availability of healthcare personnel who is able to recognize the symptoms early is needed in the community healthcare service in order to properly detect and manage the psychiatric adverse events on MDR-TB patients.

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Section: Discussionmentioning

confidence: 99%

Influence social and healthcare support on psychiatric adverse events in MDR-TB patient

Reviono

Harsini

Aphridasari

et al. 2018

J Infect Dev Ctries

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show abstract

“…Isoniazid also has an antidepressant effect, and was one of the first antidepressants discovered. [1][2][3][4][5][6][7][8] To the best of our knowledge, no cases of isoniazidinduced delirium (with all clinical features of delirium according to DSM-IV criteria) have ever been described in the literature. Peripheral neuropathy and central nervous system effects (dysarthria, seizures, dysphoria, and irritability) have also been described.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8] On the basis of this hypothesis, isoniazid therapy was stopped and substituted with moxifloxacin; sedative therapy was also progressively reduced to haloperidol 1 mg and delorazepam 1 mg once every 2 days. Among isoniazid side effects, central nervous system alterations, such as psychosis, psychomotor agitation, and drowsiness are described, although rare.…”

Section: Case Reportmentioning

confidence: 99%

A Case of Isoniazid-Induced Delirium

Demartini¹,

Camisasca²,

Zuin³

et al. 2013

JNP

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“…However, information about this issue is still limited, and it is reported generally as case reports (4,6,7). Additionally, Jackson defined in 1957 five psychiatric cases related to INH treatment, in two of which paranoid delusion were prominent (5).…”

Section: Discussionmentioning

confidence: 99%

“…INH induced psychotic diseases are rarely encountered, and the most common ones are psychosis, obsessive-compulsive disease, and mania (3). The exact mechanism of INH induced psychosis is unknown, but it has been suggested that as INH interacts with various metabolites which are necessary for normal functions of neurons, it may lead to psychosis depending problems caused by these mechanisms (4). In this case presentation, a 28 years old male patient who developed acute psychotic attack under INH treatment is reported.…”

Section: Introductionmentioning

confidence: 98%