Isometric contractile function recovery following tourniquet ischemia

Reduced ischemia-reperfusion injury in muscle Experiments in rats with EPC-K1, a new radical scavenger

“…AIthough contractile function is a clinically relevant assessment of muscle viability, only a few studies have reported the effects of antioxidant therapy on postischemic muscle contractile function (Feller et al 1989, McCutchan et al 1990). The twitch and tetanic tensions of experimental ischemic limbs in the PS group averaged 31% and 33% of nonischemic contralateral values, similarly to previous studies (Fish et al 1989, McCutchan et al 1990, Stompro et al 1994). By contrast, in the EPC group the twitch and tetanic tensions averaged 75% and 73%.…”

Ultrastructural Changes of the Neuromuscular Junction in Reperfusion Injury

“…As a consequence necrosis and the inflammatory reaction develop. However, tissue recovery processes are also activated if there is no complete destruction of the structures [Parks, 1973;Fish et al, 1989].…”

“…Reperfusion injury always develops following restoration of the blood supply if ischemia has lasted long enough. Reperfusion injury impairs muscle function leading to reduced contraction force for prolonged periods of time [Fish et al, 1989;Rá cz et al,1996]. Most studies analyzing the reperfusion injury of the skeletal muscle have focused on changes of the muscle fibers or vessels supplying the tissue [Patterson and Klenerman, 1979;Heppenstall et al, 1989;Skjeldal et al, 1991].…”

Tourniquet-induced neuromuscular injury

“…Marked isometric force decrement in rat gastrocnemius muscle (mean 66% of control force) was observed two weeks after a one hour tourniquet (Fish et al 1989). Larger deficits correlated with increasing ischemic duration up to four hours (Fish et al 1989).…”

“…Previous studies demonstrate reduction of muscle force after one hour of tourniquet compression (Gersoff et al 1989) or ischemia (Fish et al 1989). Regional necrosis was observed after two hours of tourniquet compression.…”