Isomers (oleanolic and ursolic acids) differ in their protective effect against isoproterenol-induced myocardial ischemia in rats

Selvaraj, Senthil; Chandramohan, Gangadarshni; Pugalendi, Kodukkur Viswanathan

doi:10.1016/j.ijcard.2006.07.108

Cited by 78 publications

(53 citation statements)

References 5 publications

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“…In the present experimental setting, ursolic acid treatment significantly reduced the I/R-IAKI-induced expression of TNF-α, IL-6, IL-1β and IL-10 in I/R-IAKI rats. Senthil et al (19) indicated that ursolic acids protects against isoproterenol-induced myocardial ischemia through antioxidant and anti-inflammatory functions in rats (19). This accumulation suggested that the anti-inflammatory effect of ursolic acid is associated with protection against I/R-IAKI.…”

Section: Discussionmentioning

confidence: 99%

Renoprotective effects of ursolic acid on ischemia/reperfusion-induced acute kidney injury through oxidative stress, inflammation and the inhibition of STAT3 and NF-κB activities

Peng

Ren

Lan

et al. 2016

Molecular Medicine Reports

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Abstract. Ursolic acid, a pentacyclic triterpene compound with low toxicity and easy availability, has a variety of biological activities, including antitumor, antioxidant, antihepatitis, anti-inflammatory and antibacterial effects. The present study aimed to investigate the renoprotective effects of ursolic acid on ischemia/reperfusion-induced acute kidney injury (I/R-IAKI) in rats associated with its antioxidant and anti-inflammatory effects, as well as interference with the signal transducer and activator of transcription (STAT)3/nuclear factor (NF)-κB signaling pathway. The present study demonstrated that pre-treatment with ursolic acid significantly increased renal functioning and attenuated increases of serum angiotensin II levels in rats subjected to I/R-IAKI. In addition, I/R-IAKI-induced inflammation and oxidative stress were significantly reduced by pre-treatment with ursolic acid. Furthermore, ursolic acid significantly suppressed the upregulation of STAT3, NF-κB and caspase-3 activities in rats following I/R-IAKI. These results indicated that ursolic acid may be a potential drug for reducing I/R-IAKI through suppression of inflammation and oxidative stress damage, as well as modulation of STAT3 and NF-κB activities.

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Section: Discussionmentioning

confidence: 99%

Renoprotective effects of ursolic acid on ischemia/reperfusion-induced acute kidney injury through oxidative stress, inflammation and the inhibition of STAT3 and NF-κB activities

Peng

Ren

Lan

et al. 2016

Molecular Medicine Reports

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“…We used a model of nonrelapsing, chronic sustained form of disease and demonstrated for the first time that OA, at a dose previously proved safe and therapeutically active on rodents [20,21], undoubtly inhibited the development of EAE in treated mice using two different trial At first sight, the broad effectiveness of OA on multiple signs of EAE indicates that it may affect an early phase in the immuno-inflammatory response leading to EAE, which was confirmed by the finding that triterpene attenuated the generation of certain Th1 cytokines and chemokines which are critical for the progression of the disease. We observed that OA promoted a dramatic decrease in OPN and TNF levels expressed in CNS tissues of EAE mice, and diminished the presence in sera of soluble TNF , IFN-γ, MIP-1 or MCP-1.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, we decided to evaluate the effect of OA on a murine experimental model of multiple sclerosis, EAE, at a dose previously proved to be both safe and therapeutically relevant in rodents [20,21].…”

Section: Oleanolic Acid Reduces Clinical Signsmentioning

confidence: 99%

“…It remains to be further investigated whether OA actions in neurovascular functions during EAE are exclusively related to its antiimmune/inflammatory properties or represent pleiotropic effects. Although some natural triterpenes have shown neuroprotective effects [36], inhibitory properties in arachidonic-acidmetabolizing enzymes [37], anti-oxidative properties and membrane-stabilizing actions [20], and inhibitory activity in the induction of ICAM-1 [38], no study to our knowledge had in fact been performed linking these actions to BBB integrity.…”

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confidence: 99%

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Beneficial actions of oleanolic acid in an experimental model of multiple sclerosis: A potential therapeutic role

Martín

Carvalho‐Tavares

Hernández

et al. 2010

Biochemical Pharmacology

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Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease for which there exist no therapies without undesired side effects. Thus, the establishment of less toxic treatments is an ongoing challenge. Nowadays, research on medicinal plants has been attracting much attention, since screening of its active principles could prove useful in identification of safe and innovative pharmaceutical molecules. In this study we investigated the therapeutic effect of oleanolic acid (OA) a plant-derived triterpene with potent anti-inflammatory and immunomodulatory activities, whose actions on CNS diseases remain far from completely characterized. We focussed on the potential therapeutic effect of oleanolic acid (OA) on an accepted experimental model of MS, the experimental autoimmune encephalomyelitis (EAE).We have found that OA treatment, before or at the early onset of EAE, ameliorates neurological signs of EAE-mice. These beneficial effects of OA seem to be associated with a reduction of blood-brain barrier leakage and lower infiltration of inflammatory cells within the CNS, as well as with its modulatory role in Th1/Th2 polarization: inhibition of proinflammatory cytokines and chemokines, and stimulation of anti-inflammatory ones.Moreover, EAE-animals that were treated with OA had lower levels of anti-MOG antibodies than untreated EAE-mice.Our findings show that the administration of the natural triterpenoid OA reduces and limits the severity and development of EAE. Therefore, OA therapy might be of clinical interest for human MS and other Th1 cell-mediated inflammatory diseases.

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“…Phytochemical analysis of this fraction indicated that the actives compounds are oleanolic acid (OA) and ursolic acid (UA). These two compounds are pentacyclic triterpenoids having a similar chemical structure and are the major components of many medicinal plants and herbs widely distributed all over the world and these components have attracted a lot of attention because of their various biological activity such as anti-inflammatory, antioxidant, hepatoprotective, cytotoxic, antitumor and antiangiogenis [13][14][15][16][17][18]. So the proapoptotic effect of fraction II is not very surprising event because the presence of these antitumor compounds [19] but it's mechanism of actions needs to more investigation.…”

Section: Discussionmentioning

confidence: 99%

Apoptosis Induction by Cestrum parqui L’Hér. leaves on HL-60 Cell Line: Identification of Active Phytomolecules

Chenni¹,

Torres²,

Estévez³

et al. 2015

IJCR

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IntroductionCancer, one of the leading causes of human death, has attracted more attention due to the complexity of etiology, diagnosis and treatment [1]. In recent years, chemotherapeutic management against various types of cancer including leukemia has been increased rapidly though some times cancer cells resistance against chemotherapy [2,3]. In this respect, search for effective anticancer agent that inhibit the proliferation of the cells as well as inhibit the resistance nature of the cancer cells and induce differentiation of the monocytes is an ongoing challenge. Therefore to find out anticancer agent with multi-target efficacies, attention has been focused on plant products as the plant products have been used as remedies for several human diseases including cancer from ancient times with lower side effects [4]. The reasons for using them that they contain variety of chemical compounds usually secondary metabolites with therapeutic values [5]. Cestrum parqui is belonging to the family Solanaceae, usually known as "green or Chilean cestrum" in Tunisia, are rich in various secondary metabolites such as saponins, polyhydroxylated terpenes (C13 norisoprenoids, sesquiterpenes, spirostanes and pseudosapogenins) and ent-kaurene glycosides (parquin and carboxyparquin) [6][7][8]. Several scientific reports demonstrate that C. parqui exhibits a wide spectrum of pharmacological activity when administered systemically or in isolated organ preparations. For example, it is used to treat headache, rheumatic pain, scabies, dermatosis, diarrhaea and metrorraghia [7]. The plant is also used in Chilean folk Abstract Background: In our time, there is an urgent need to discover natural anticancer products without toxic side's effects. Objective: The present study was conducted to investigate the anticancer activity of the methanolic extract of Cestrum parqui leaves as well as identification of the active compounds in this concern. Materials and Methods: Eight column chromatographic fractions were tested against human leukaemia cell line (HL-60) and the cell viability was measured by dimethylthiazol tetrazolium assay. Studies of apoptosis, cell cycle and DNA fragmentation were carried out following the standard protocol. Effective fractions were analysed by high performance liquid chromatography-ultra violet, HPLC-evaporative light scattering detector and preparative-HPLC. Finally the active compounds were identified by gas chromatography coupled to mass spectrometry. Results: Out of eight, fraction II showed remarkable inhibition on the growth of HL-60 cell line and fraction I showed moderate activity on such inhibition. Mechanisms of the inhibition were identified as cell cycle arrestation and apoptosis induction by the said fractions. Chromatographic and mass spectrometric analysis of the fraction II indicated the presence of oleanolic and ursolic acids as biologically active compounds. Conclusion: This study is the first investigation that shows Cestrum parqui has anticancer activity and the responsible compounds are olea...

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Isomers (oleanolic and ursolic acids) differ in their protective effect against isoproterenol-induced myocardial ischemia in rats

Cited by 78 publications

References 5 publications

Renoprotective effects of ursolic acid on ischemia/reperfusion-induced acute kidney injury through oxidative stress, inflammation and the inhibition of STAT3 and NF-κB activities

Renoprotective effects of ursolic acid on ischemia/reperfusion-induced acute kidney injury through oxidative stress, inflammation and the inhibition of STAT3 and NF-κB activities

Beneficial actions of oleanolic acid in an experimental model of multiple sclerosis: A potential therapeutic role

Apoptosis Induction by Cestrum parqui L’Hér. leaves on HL-60 Cell Line: Identification of Active Phytomolecules

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