1996
DOI: 10.1007/bf02333885
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Isomerization of glycyrrhizic acid. Antiulcer activity

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Cited by 8 publications
(7 citation statements)
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“…It was not allergic, teratogenic or mutagenic, and did not change blood indexes and plasma enzymes activity when administered per os (7 mg/kg30 times) [99][100][101]. GL derivatives were low toxic compounds too (LD 50 = 800-8000 mg/kg per os) [63,[68][69][70][71][72][73]76].…”
Section: Pharmacological Properties Of Glycyrrizic Acid Derivativs Anmentioning
confidence: 99%
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“…It was not allergic, teratogenic or mutagenic, and did not change blood indexes and plasma enzymes activity when administered per os (7 mg/kg30 times) [99][100][101]. GL derivatives were low toxic compounds too (LD 50 = 800-8000 mg/kg per os) [63,[68][69][70][71][72][73]76].…”
Section: Pharmacological Properties Of Glycyrrizic Acid Derivativs Anmentioning
confidence: 99%
“…Triacylisocianate (67) reacted with primary amines forming appropriate triacylthioureids (68)(69)(70)(71), and with hydrazines formed acylthiocemicarbazides (72-77) (scheme 1) [73].…”
Section: Synthesis Of Acylthioureides and Semicarbazidesmentioning
confidence: 99%
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“…[16] Гли-цирризиновая кислота не устойчива к нагреванию. [17] Установлено, что при хранении некоторых лекарствен-ных форм с GC в них быстро уменьшается его содер-жание даже при комнатной температуре.…”
Section: Physico -Chemical Characteristic and Biological Activity Of unclassified
“…Compound I was prepared by alkaline isomerization of 18b-GA (92%) as described in [19], followed by purification as potassium salts by dissolution in acetone and precipitation of the 3K salt of I with 10% KOH/MeOH solution, conversion of 3K salts of I into monopotassium salts (II) by crystallization from glacial acetic acid, and recrystallization from aqueous ethanol. Treatment of purified salts II with the cation exchange resin KU-2-8 in the H + form in 85% EtOH yielded acid I with a purity of 85 ± 2% (HPLC data), which was used to prepare esters (III -VI).…”
mentioning
confidence: 99%