Isomerization and Following Alkylation of (Z,e)-2-Octen-4-Yn-1-Ol as a One Pot Procedure in Super Basic Media

Abstract

Anionotropic isomerization of the enynic block of (Z,E)-2-octen-4-yn-1-ol in super basic media MNH(CH,),NH,/H,N(CH,),NH, (M = Li, Na) and the following alkylation in situ of the metallated product was studied. The influence of the strength of the super base and the structure of the alkylating agent to the yield and isomeric composition of products were determined.